Abstract: An automated system and method for testing a sensor by evaluating the output thereof with respect to a known target. The advantageous method includes the step of acquiring an output signal from the sensor in response to a known target, said output including signature signal S, random noise N.sub.R and fixed pattern noise N.sub.FP. Next, the sensor output signal is processed to provide a first signal which includes essentially signature signal S and fixed pattern noise N.sub.FP, a second signal which includes essentially random noise N.sub.R and a third signal which includes essentially fixed pattern noise N.sub.FP. The third signal is adaptively filtered to provide a filtered signal fixed pattern noise signal N'.sub.FP. The filtered signal N'.sub.FP is subtracted from the first signal to extract a signature S. In a particular embodiment, the signature is processed to acquire a modulation transfer function and a signal peak baseline therefrom.