Abstract: The present disclosure provides fully human antibodies that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus with high affinity, or antigen-binding proteins derived from such antibodies, and uses thereof. Included are anti-spike protein antibodies, antibody fragments, and single-chain antibodies, that are coronavirus neutralizing antibodies, as well as pharmaceutical compositions that include such antibodies and antibody fragments. Methods for using the anti-spike protein antibodies include methods of treating or preventing infection with a coronavirus, such as the SARS-CoV-2 coronavirus, by administering an antibody or antibody fragment as disclosed herein, including by intranasal delivery. Methods and compositions for treating or preventing coronavirus infection by administering a composition that includes a nucleic acid construct that encodes a neutralizing antibody are also provided.

Abstract: Disclosed herein is a method for communicating between platforms, comprising the steps of initializing a first platform and a second platform; optically tracking a movement of the second platform by the first platform; and optically communicating bi-directionally between the first platform and the second platform. Disclosed herein is an optical communication device comprising various elements including but not limited to: a processor configured to provide at least a tracking mode and a communications mode; an input-output interface coupled to the processor; an electro-optic controller coupled to the input-output interface; an acquisition-tracking portion coupled to the electro-optic controller; and a communication portion coupled to the electro-optic controller.

Abstract: Disclosed herein is a method for communicating between platforms, comprising the steps of initializing a first platform and a second platform; optically tracking a movement of the second platform by the first platform; and optically communicating bi-directionally between the first platform and the second platform. Disclosed herein is an optical communication device comprising various elements including but not limited to: a processor configured to provide at least a tracking mode and a communications mode; an input-output interface coupled to the processor; an electro-optic controller coupled to the input-output interface; an acquisition-tracking portion coupled to the electro-optic controller; and a communication portion coupled to the electro-optic controller.

Abstract: A conveyor system has an endless belt with an upper transport portion sized to support a wheeled structure, and a lower return portion. A support deck is positioned to support the upper transport portion of the endless belt, the support deck includes a lower support deck structure, and wear plates that are supported on the lower support deck structure. The support deck includes alignment aperture pairs. Each alignment aperture pair includes a first alignment aperture through the lower support deck structure, and a second alignment aperture through one of the plurality of wear plates. A belt-rinsing system is provided and includes a plurality of rinsing system outlet bodies, wherein each of the plurality of rinsing system outlet bodies extends into one of the first alignment apertures of the lower support deck structure and into one of the second alignment apertures of one of the plurality of wear plates.

Abstract: The present disclosure provides antigen-binding proteins, such as fully human antibodies, that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus and uses thereof. In various embodiments, the anti-spike protein antibodies are neutralizing antibodies that prevent binding of the SARS-CoV-2 coronavirus to a target cell expressing the ACE2 protein. Included are anti-spike protein antibodies, antibody fragments, and single-chain antibodies, as well as pharmaceutical compositions that include such antibodies and antibody fragments. Also provided herein are nucleic acids and recombinant expression vectors that encode the anti-spike protein antibodies and antibody fragments disclosed herein and transgenic cells transected with such nucleic acids and expression vectors. Further provided are methods for preparing and using such anti-spike protein antibodies.

Abstract: Disclosed is a system and method for operating an imaging system. The imaging system may move or be moved to acquire image data of a subject at different positions relative to the subject. The image data may, thereafter, be combined to form a single image.

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.

Abstract: A wire terminating apparatus and method which allows for determining the quality of a wire termination. The method includes terminating the wire, monitoring the thermal properties of the termination with one or more thermal sensors and comparing the monitored thermal properties to stored thermal properties to determine if the termination is defective. If the termination is defective, the termination is discarded. The apparatus includes a wire termination zone. A thermal sensor is mounted on the wire terminating apparatus proximate the wire termination zone. The thermal sensor monitors the thermal properties of the termination to determine if the termination is defective.

Abstract: Some aspects of the present invention may include systems and methods of a detecting whether a first image contains a region that has been manipulated, methods comprising obtaining a second image, wherein the second image comprises at least a part of the first image, said at least a part of the first image containing the region suspected of being manipulated; determining a numerical value of an order parameter (S or S2) of the second image; determining a numerical value of an order parameter (S or S2) of a third image, the third image comprising the second image with the region suspected of being manipulated removed; and comparing the numerical value of the second image (S or S2) with the numerical value (S or S2) of the third image to determine if the first image has been altered, by reference to a predefined criteria indicative of a manipulated image.

Abstract: Some aspects of the present invention may include a method of fabricating an electrolyte suitable for a fuel cell or electrolyzer, comprising: determining one or more or two or more target material properties of the electrolyte or overall or overall system-level property of the fuel cell or electrolyzer; utilizing a predefined quantitative relationship between a material property and an order parameter involving one or more electrolyte components to determine at least one material ordering that has the target material property; and controlling process parameters to form at least one electrolyte material having the target material property. Some aspects of the present invention may include a method of fabricating an electrolyte suitable for a fuel cell or electrolyzer, to determine at least one or more material orderings that that provides the best overall performance for the device.

Abstract: A method includes the steps of receiving, from a first casino, first casino slot machine data on a per-spin basis from at least one slot machine at the first casino, receiving, from a second casino, second casino slot machine data on a per-spin basis from at least one slot machine at the second casino, comparing the first and second casino slot machine data to at least one predetermined threshold, based at least on comparing the first casino slot machine data to the at least one predetermined threshold outputting a first recommendation to the first casino, and based at least on comparing the second casino slot machine data to the at least one predetermined threshold outputting a second recommendation to the second casino.

Abstract: A bioreactor for producing hydrogen gas and other metabolites. The bioreactor utilizes light, fermentation, and other metabolic processes for the production of metabolites, derived from various microorganisms contained within the bioreactor through respective metabolic pathways. The bioreactor comprises a main reactor chamber, a semipermeable membrane, a sleeve, a power supply, a substrate medium, a heating member, a plurality of tubing members, a collection reservoir, a pressure-sealed connecter member, and an agitator.

Abstract: An embodiment of the invention provides a method where retractable ducts or shrouds are extended over propeller(s) that are fixed in wing channels on an aircraft during takeoff and landing to increase flight safety and efficiency. Fully extending the duct or shroud during takeoff increases lift and upward thrust, while retracting the duct or shroud and stowing the duct or shroud inside of the wing during forward cruise decreases aircraft drag and increases lift. Duct or shroud extension during takeoff also enables critical safety and noise cancellation functionality. The method provided for safe and efficient takeoff can be applied in reverse order for safe and efficient landing.

Abstract: Techniques for providing using software applications within persistent hybrid virtual collaborative workspaces are provided. In an example, a method establishes a virtual collaborative workspace characterized by or more virtual collaborative workspace resources and associated with one or more users to interact with other users or collaborative workspace resources within the virtual collaborative workspace. The method further receives, from a client device associated with a first user associated with the virtual space, an identification of an application to use in the virtual collaborative workspace. The method, based on the receiving, adds the application to the virtual collaborative workspace and configures the application to access one or more resources associated with the virtual collaborative workspace. The method further provides access to the application within the virtual collaborative workspace to at least a subset of the users associated with the virtual collaborative workspace.

Abstract: A frictionally-retained detachable dental attachment assembly or anchor device is designed to attach a dental appliance with a tooth root or implant. The assembly includes a denture attachment housing for securing in the dental appliance, an abutment attached with a tooth root or implant, and a compressible retention member with a first end in fixed attachment with the cap and a second end in snap engagement with the abutment via a frictionally-retained ball secured within a cavity of the abutment. The retention member is formed using a compressible material to allow the ball to compress and the retention member to flex while inserting the ball into the cavity. Additional friction-retained and fixed attachment configurations of the dental anchor device are provided, along with methods of securing a dental appliance in a subject's mouth by means of the friction-retained and fixed attachment dental anchor devices.

Abstract: Recombinant oncolytic viruses that produce and secrete novel immunomodulatory fusion proteins are described. The fusion proteins encode a single chain variable fragment antibody (ScFv) that specifically binds PD-1 OR PD-L1 fused via an antibody Fc region to the ectodomain of the TGF? receptor II (TGF?RIIecto). The immunomodulatory fusion proteins have dual function: blocking inhibitory pathways mediated by PD-1/PD-L1 and blocking the immune-dampening activity of TGF?. In addition, dual gene oncolytic herpes simplex viruses (HSVs) are provided that include, in addition to a gene encoding an ScFv-Fc-TGF?RIIecto fusion protein, a gene encoding IL12, a T cell stimulatory factor.

Abstract: An apparatus and method for facilitating the removal of layers from a die for an integrated circuit while maintaining the planarity of the surface of the die by avoiding rounding the corners and other edges of the die. A pocket is created in a sacrificial material, such that when the die is inserted into the pocket the edges of the die are contiguous with the walls of the pocket and a top surface of the die is coplanar with a top surface of the pocket. The sacrificial material may be the same material as the die. An adhesive substance is placed in the pocket, and the die is inserted into the pocket and against the adhesive substance which aids in retaining the die in the pocket. The layers may then be removed from the die and the sacrificial material around the die without rounding the edges of the die.

Abstract: One example method includes receiving a request to join a virtual space, the request received from a user device associated with a first user; responsive to determining that the first user is a member of the virtual space, providing access to the virtual space; changing a status of the first user based on the first user accessing the virtual space; providing state information associated with a then-current state of the virtual space; and providing an indication of a conference attached to the virtual space to the first user, the conference being between two or more members of the virtual space.

Abstract: One example method includes generating, by a conference provider, a virtual space; adding a plurality of members to the virtual space; adding one or more resources to the virtual space in response to one or more inputs from one or more of the members; initiating, by the conference provider, a conference between two or more of the members; attaching the conference to the virtual space; and providing an indication of the conference in the virtual space.

Abstract: Techniques for managing outputs from persistent hybrid collaborative workspaces are disclosed. In an example, a method receives, from a client device, a request to view a history of the virtual collaborative workspace. The method obtains, from a data store, past occurrences associated with one or more virtual collaborative workspace resources within the virtual space. The virtual collaborative workspace resources can include a virtual collaborative workspace, a list of users associated with the virtual collaborative workspace, a shared document, a video stream, or textual messages. The method further transmits indications of the one or more virtual collaborative workspace resources to the client device.