Abstract: A method/system monitors and controls operational aspects of devices in a space, for example a living, office or other human-occupied space or storage space, in a building, such as turning lights on/off, raising/lowering blinds, maintaining or changing temperature, and other operational aspects. Sensors monitor energy usage of the devices in the space, and a controller/engine compares the monitored energy usage with reference energy usage to validate whether the devices are performing as expected. A temperate set-versus-anomaly detection technique may use temperature set point adjustments by a user (during a timeframe) to determine whether an anomaly exists that requires changes in the central plant of the building.

Abstract: A rotary cutting tool for use in a wellbore has an instrumented cutter fitted into a cavity in the tool body. The instrumented cutter body has an outer end portion exposed at the open end of a cavity and is connected to the tool body through at least one connecting section having a smaller cross-section and greater compliance than the outer end portion. The outer end portion and the connecting section are slightly movable within the cavity but the cavity surrounds at least part of the outer end portion sufficiently closely to limit transverse movement to elastic strain of the compliant connecting portion. One or more sensors, which may be strain gauges, are used to measure force on the outer end portion in a plurality of directions transverse to the cavity and causing elastic strain of the at least one connecting section.

Abstract: A method of fabricating cooling features on a CMC component may comprise compressing a fabric preform within tooling including holes and/or recesses facing the fabric preform. During the compression, portions of the fabric preform are pushed into the holes and/or recesses. Gases are delivered through the tooling to deposit a matrix material on exposed surfaces of the fabric preform while the fabric preform is being compressed. The matrix material builds up on the portions of the fabric preform pushed into the holes and/or recesses, and a rigidized preform with surface protrusions is formed. The tooling is removed, and the rigidized preform is densified, thereby forming a CMC component including raised surface features.

Abstract: A respiratory disease analytics system provides respiratory disease risk reports to a patient, provider, or third-party entity describing a patient's risk of experiencing a medication usage event given data in a geographic region. Regional data, including air pollutant conditions, weather conditions, demographic information, built environment factors, and regional health conditions for a geographic region are accessed from other sources and assigned based on event data recorded during a medicament usage event, as collected by sensors associated with the patient's medicament device/s. The regional data is assigned to medicament usage events occurring within a period of time. The assigned regional data is analyzed to determine an expected number of medication usage events for the geographic region occurring over the period of time.

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Abstract: The present invention is generally directed to a system for providing heating, cooling, and domestic hot water (DHW) using a water source heat pump, the system including: a compressor; a source heat exchanger; a load heat exchanger; a DHW heat exchanger; and a DHW storage tank. In some embodiments, the system may be concealable, and mounted between two wall studs. In some embodiments, a water-to-water water source heat pump and DHW storage tank may be mounted between the same wall studs, the system having a width of no more than 14.5? and a depth of no more than 7?. In some embodiments, in a heating cycle high-temperature high-pressure refrigerant in a gaseous phase is provided to both a brazed plate DHW heat exchanger and a brazed plate load heat exchanger in a parallel manner so one of the heat exchangers receives the refrigerant at a time.

Abstract: This description provides risk notifications for a geographic region to inform patients and effect behavior changes to prevent rescue events and exacerbations from occurring. A risk analysis for a geographic region is based on data gathered from a population of patients who may experience respiratory events within the geographic region. Rescue medication events, environmental conditions relevant to the rescue medication events, and other contextually relevant information are detected by sensors associated with a population of patients' medicament device/s and are collected from other sources, respectively, to provide a basis to determine a risk score. This data is analyzed to determine the severity of the risk of a respiratory event occurring within a geographical region and accordingly sending a notification to patients within that geographical region.

Abstract: A magnetically geared apparatus comprising a rotor, the rotor comprising: a ring structure; and at least one pole piece mounted relative to the ring structure; wherein at least a portion of the ring structure forms a continuous ring radially inner to the at least one pole piece, wherein the at least one pole piece is received in a pole piece-receiving portion, the pole piece receiving portion being open at a radially outer end.

Abstract: A rotary tool for operation within an underground borehole or within tubing in a borehole has a tool body and at least one sensor-containing unit attached to the tool body and positioned to contact the conduit wall. The sensor-containing unit includes an exterior portion to contact the borehole or tubing wall and one or more sensors is located in a cavity between the exterior portion and the tool body. The sensor-containing unit may be formed from the exterior portion, an attachment portion for attachment to the tool body, and one or more connecting portions extending between the attachment and exterior portions, with the sensor-containing cavity between the attachment and exterior portions. Possible rotary tools include drill bits, reamers, mills, stabilizers, and rotary steerable systems.

Abstract: A computer-implemented method comprises sending, to a first device, a request for a signed certificate, the request for the signed certificate comprising a signed hash of data associated with a user, a corresponding public key of the user, and the data associated with the user; sending, to a second device different from the first device, a request for the signed certificate, the request comprising information to retrieve the signed certificate; and obtaining, from the second device, a signed certificate, the signed certificate comprising the public key of the user, the hash of the data associated with the user, and information indicating a health status of the user, the data associated with the user being absent from the signed certificate.

Abstract: A rotary tool for operation within an underground wellbore or within tubing in a wellbore has at least one force-sensitive element attached to the tool body and positioned to contact the conduit wall, wherein the force-sensitive element comprises an outer portion to contact the wellbore or tubing wall, at least one connecting portion which is more compliant than the outer portion and through which the outer portion is connected to the tool body, and at least one sensor responsive to force on the outer portion transmitted through the force-sensitive element to the tool body. The sensors may resolve forces into measurable forces on three axes. Possible rotary tools include drill bit, reamer, mill, stabilizer and rotary steerable system for a drill bit.

Abstract: A face spline coupling for transmitting torque between a wheel end unit and a driven shaft arranged in a longitudinal axis of a drive-wheel arrangement for a motor vehicle includes a first face spline formed in the wheel end unit and a second face spline formed in the driven shaft. The first face spline is generally perpendicular to the longitudinal axis and faces the driven shaft, and the second face spline is also generally perpendicular to the longitudinal axis and faces the wheel end unit. The first and second face splines are meshed together and detachably coupled by inter-fitting teeth of each of the first and second face splines. In addition, the teeth in each of the first and second face splines are formed in a helical configuration.

Abstract: A drivetrain assembly for a motor vehicle including a venting system. The drivetrain assembly includes an output shaft from a vehicle prime moreover component such as a transmission or transaxle. The output shaft is coupled to a propeller shaft through a constant velocity joint (CVJ) assembly. A flexible sealing boot encloses the CVJ between the output shaft and the propeller shaft. Internal components of the CVJ are vented by a first longitudinal passageway exposed to the internal volume of the CVJ extending longitudinally along the output shaft. A second radial passageway joins the longitudinal passageway and extends to the radially outer surface of the output shaft forming a second aperture. The passageways combine to provide pressure equalization between the CVJ internal volume and the atmosphere. An optional semi-permeable membrane may be mounted at the second aperture.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A magnetically geared apparatus comprising a rotor, the rotor comprising: a ring structure; and at least one pole piece mounted relative to the ring structure; wherein at least a portion of the ring structure forms a continuous ring radially inner to the at least one pole piece, wherein the at least one pole piece is received in a pole piece-receiving portion, the pole piece receiving portion being open at a radially outer end.

Abstract: Systems and techniques are disclosed for using machine learning to dynamically detect physical impairments in lines of a subscriber network. In some implementations, per-tone data for a line of a subscriber network and data indicating a set of one or more scores is obtained. Each score included in the set of scores indicates a conditional likelihood that the line has a type of impairment with respect to a different feature subset ensemble. The per-tone data and the data indicating the set of one or more scores is provided as input to a model. The model is trained to output, for each of different sets of feature subset ensembles, a confidence score representing an overall likelihood that a particular line has a physical impairment. Data indicating a particular confidence score representing an overall likelihood that the line has the physical impairment is obtained. The particular confidence score is provided for output.