Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.

Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.

Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.

Abstract: Basketball training apparatus uses a first vertical support member having a lower end adapted to rest on a supporting surface. An elongated guide rod extends in longitudinal direction. An adjustable wrist support is adapted for manual engagement and disengagement of a wrist of a user. A second elongated member is secured rotatably at one end to one end of the rod and extends at right angles thereto. The other end of the second member is secured to the wrist support. A device is secured to the upper end of the member and is manually pivotable about a horizontal axis disposed at right angles to the longitudinal direction, the device providing a guide channel through which the rod extends.

Abstract: A fisherman's bobber takes the form of a hollow one piece plastic spheroid having two mating halves joined together by corresponding portions of a living hinge. The hinge extends outwardly from both halves. The interior peripheral surfaces of both halves are contoured to enable the halves to be joined together in locking engagement when the halves are pressed together and to permit the halves to be unlocked and swung apart when squeezed together. The portions of the hinge when the halves are locked together hold a fishing line in locking engagement therebetween.

Abstract: A thin elongated plastic member has at one end a golf club shaft receiving groove that is disposed between two opposite finger like supporting arms which extend longitudinally outward. The groove is integral with a first short slot extending longitudinally inward in opposite direction from the arms. Two oppositely disposed spaced apart scissor like prongs extend longitudinally outward and are separated by a second short slot extending longitudinally inward in opposite direction from the prongs.

Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): 1

Abstract: A first horizontal hollow cylinder open at both ends has a first narrow elongated slot. A second horizontal hollow cylinder open at both is disposed concentrically within the first cylinder and has a second narrow elongated slot that extends between its ends. A vertical elongated element is secured at its upper end to said cylinder and has an opening intermediate its ends. A flexible elongated connector secured at one end to the lower end of said element with its other end being detachably securable with said element opening. A rotatable member is secured to one end of the second cylinder and is spaced from the first cylinder so that the member can rotate the second cylinder about its axis without rotating the first cylinder that remains in fixed non-rotatable position. The member has a first position of rotation at which the two slots are aligned and a second position of rotation at which said slots are out of alignment.

Abstract: A first horizontal hollow cylinder open at both ends has a first narrow elongated slot. A second horizontal hollow cylinder open at both ends is disposed concentrically within the firtst cylinder and has a second narrow elongated slot that extends between its ends. A vertically elongated element is secured at its upper end to the first cylinder and has an opening intermediate its ends. A flexible elongated connector secured at one end to the lower end of the element with its other end being detachable with the element opening. A rotatable member is secured to one end of the second cylinder and is spaced from the first cylinder so that the member can rotate the second cylinder about its axis without rotating the first cylinder.

Abstract: A golf club holder adapted for removably supporting a golf club above a ground surface in such manner that the club has a head which contacts the surface and the club has a shaft which extends above the surface.

Abstract: A holder for a golf club employing two joined but relatively adjustable members for detachably receiving and holding the club and a vertical spike suspended between the members.

Abstract: A cap adapted to be secured to an open end of a container employs a vertical hollow cylinder provided with an open lower end adapted to be secured to the open end of the container and a closed upper end with a small centrally disposed first opening therein surrounded by a raised peripheral first lip. The cylinder upper end has a second peripheral lip extending upwardly above the first lip, the second lip having first and second oppositely disposed cut out regions communicating with the cylinder upper end. A first horizontally elongated flexible member has first and second opposite ends each of which is aligned with the corresponding one of the first and second regions and is disposed between the first and second lips. The first member has a flat top surface and a downwardly depending extension which slidably engages the first lip. The extension in a horizontal plane defines a FIG. 8 with left hand and right hand sections.

Abstract: A device adapted for use in locking a window in closed position or in partially or fully open position which utilizes an elongated locking pin; and a flexible spiral shaped spring lying in a plane perpendicular to the direction of elongation of the pin. The spring has an inner end secured to the pin at a position intermediate the ends of the pin. The spring has an outer end with an opening therein.

Abstract: A pressurized inverted dispenser utilizes a hollow vertically elongated body having a lower end with an aperture, an upper end, a flat vertical cover and a front curved wall with a button receiving opening. The front wall, the cover, the upper end and the lower end are sealed together. The inside surface of the cover carries a connector support. A button is disposed in the opening which is slidably movable toward and away from the rear wall between depressed and extended positions. A horizontally elongated connector secured to the rear surface of the button and slidably engages the connector support. The button slidably supports a horizontal leg of a spring which also has a vertical end leg aligned with the aperture, and a U shaped central section disposed between and secured to the first and second legs.

Abstract: A vertical hollow cylinder has an open bottom end and a closed top end having a first opening. A vertical hollow tube is open at both ends. A vertical inverted truncated hollow cone is open at both ends. The smaller open end of the cone is connected to the upper open end of the tube. A vertical cup shaped element has a first flat horizontal surface having a central hole coincident with the larger cone end and containing a plurality of small holes spaced from each other and from the central hole. The element has a second flat horizontal surface spaced slightly above the first surface and disposed around the central hole and the small holes. The top surface of the element engages the top end of the cylinder, the tube, cone and element being aligned with the first opening. A flat flexible disc has a flapper valve disposed in its center aligned with the first opening and also has a plurality of short vertical flexible fingers closely spaced from each other.

Abstract: A hollow vertical cylinder has a closed vertical side wall and closed upper and lower ends. The cylinder has an upper region for receiving pills and a lower region from which pills are dispensed. A portion of the upper region is removable. The lower region has a first opening in its lower end which is adapted to pass a pill therethrough and has at least one second opening in its side wall. A thin horizontal partition disposed in the cylinder defines a bottom horizontal surface for the upper region and a top horizontal surface for the lower region and also separates each of the regions from the other. The partition has a third opening adapted to pass a pill therethrough, the third opening being out of alignment with the first opening. A structure disposed in the lower region adjacent the partition has a lever extending outwardly through a second opening in the side wall.

Abstract: A first vertical hollow cylinder is secured at an open lower end to the open end of the container. The first cylinder having a closed upper end with a small centrally disposed first opening therein and has a raised peripheral first lip. A curved vertical wall is secured to and extends upwardly from this upper end of the first cylinder. The wall engaging the first lip at two spaced apart positions and curves around one side of the first opening. A second vertical hollow cylinder open at both ends and secured to the upper end of the first cylinder so that its axial bore is vertically aligned with the first opening. A horizontally elongated member defines a figure 8 with left hand and right hand like half sections, each half section having a hole therein. One hole is sealed, the other hole being open. The member rests slidably on top of the second cylinder, with one member side slidably engaging the wall.

Abstract: An integral plastic sinker slider structure utilizes a first hollow cylinder open at both ends. A second hollow cylinder is open at both ends and is parallel to the first cylinder. The two cylinders are disposed side by side and are secured together. The second cylinder is disposed below the first cylinder and has an outer wall with a plurality of equidistantly spaced elongated slots that extend in parallel from one end of the second cylinder to a point intermediate the ends of the second cylinder and form a flexible region with the said one end. This region has an first internal longitudinal bore with a first cross sectional area, the remainder of the second cylinder having a second internal longitudinal bore which is a continuation of the first bore with a second and larger cross sectional area. An elongated member is secured at one end to the outer wall of the second cylinder and has a third cross sectional area intermediate its ends which is smaller than the first area.

Abstract: A squeeze sprayer device is attached to a squeezable container of fluid. The device includes a capped cylinder containing an axially moveable discharge valve in the form of an air piston which unseats in response to air pressure to open the discharge upon squeezing the container for producing a fine mist spray as pressurized air admixes with the liquid at the discharge orifice. A one-way valve controlled air vent on the piston closes during the spray operation. Upon release of squeeze pressure, the piston returns, its one-way valve opens for venting, and the piston seal cuts off the spray.

Abstract: A foam dispenser includes an elongated squeezable relatively small vertical container having a top disposed open neck and being otherwise sealed. An elongated vertical member has hollow upper and lower sections which communicate with each other. The upper end of the upper section has a relatively large opening. The lower section has a relatively small opening. The member is sealed in the neck with the large opening disposed above the neck and constituting a discharge orifice. At least two vertically spaced horizontal sieves are sealed one below the other in the orifice. The upper one of the sieves is a fine sieve, the lower one of the sieves is a coarser sieve.