Abstract: Compositions and methods for modifying the expression of one or more chitinase proteins in a target cell or tissue type are disclosed. The compositions can be used in methods of treating a disease condition associated with expression of a chitinase protein in a cell or tissue type in a subject in need thereof, such as ALS and PD.

Abstract: A fixture configuration module comprises a connector configured to be removably coupled with a light fixture. The fixture configuration module also comprises fixture control circuitry communicatively coupled to the connector and configured to control the light fixture to produce light in accordance with a range of a lighting parameter. The range includes at least a subset of values supported by the light fixture for producing light. The fixture configuration module further comprises range control circuitry communicatively coupled to the fixture control circuitry and configured to wirelessly receive the range at least while the connector is uncoupled from the light fixture, and designate the range to the fixture control circuitry while the connector is coupled to the light fixture.

Abstract: An image sensor includes an active pixel array including a number of pixels and image sensor control circuitry configured to perform a read operation only on a subset of the pixels of the active pixel array such that pixels not in the subset remain inactive. By reading out only the subset of pixels in the active pixel array and keeping the remaining pixels inactive, the temperature of the active pixel array may be reduced compared to a conventional read out process, thereby reducing thermal noise in the resulting pixel data.

Abstract: A distributed, parallel, image capture and processing architecture provides significant advantages over prior art systems. A very large array of computational circuits—in some embodiments, matching the size of the pixel array—is distributed around, within, or beneath the pixel array of an image sensor. Each computational circuit is dedicated to, and in some embodiments is physically proximal to, one, two, or more associated pixels. Each computational circuit is operative to perform computations on one, two, or more pixel values generated by its associated pixels. The computational circuits all perform the same operation(s), in parallel. In this manner, a very large number of pixel-level operations are performed in parallel, physically and electrically near the pixels.

Abstract: A distributed, parallel, image capture and processing architecture provides significant advantages over prior art systems. A very large array of computational circuits—in some embodiments, matching the size of the pixel array—is distributed around, within, or beneath the pixel array of an image sensor. Each computational circuit is dedicated to, and in some embodiments is physically proximal to, one, two, or more associated pixels. Each computational circuit is operative to perform computations on one, two, or more pixel values generated by its associated pixels. The computational circuits all perform the same operation(s), in parallel. In this manner, a very large number of pixel-level operations are performed in parallel, physically and electrically near the pixels.

Abstract: A fixture configuration module comprises a connector configured to be removably coupled with a light fixture. The fixture configuration module also comprises fixture control circuitry communicatively coupled to the connector and configured to control the light fixture to produce light in accordance with a range of a lighting parameter. The range includes at least a subset of values supported by the light fixture for producing light. The fixture configuration module further comprises range control circuitry communicatively coupled to the fixture control circuitry and configured to wirelessly receive the range at least while the connector is uncoupled from the light fixture, and designate the range to the fixture control circuitry while the connector is coupled to the light fixture.

Abstract: A distributed, parallel, image capture and processing architecture provides significant advantages over prior art systems. A very large array of computational circuits—in some embodiments, matching the size of the pixel array—is distributed around, within, or beneath the pixel array of an image sensor. Each computational circuit is dedicated to, and in some embodiments is physically proximal to, one, two, or more associated pixels. Each computational circuit is operative to perform computations on one, two, or more pixel values generated by its associated pixels. The computational circuits all perform the same operation(s), in parallel. In this manner, a very large number of pixel-level operations are performed in parallel, physically and electrically near the pixels. This obviates the need to transfer very large amounts of pixel data from a pixel array to a CPU/memory, thus alleviating the significant high-speed performance constraints placed on modern image sensors.

Abstract: A fixture configuration module comprises a connector configured to be removably coupled with a light fixture. The fixture configuration module also comprises fixture control circuitry communicatively coupled to the connector and configured to control the light fixture to produce light in accordance with a range of a lighting parameter. The range includes at least a subset of values supported by the light fixture for producing light. The fixture configuration module further comprises range control circuitry communicatively coupled to the fixture control circuitry and configured to wirelessly receive the range at least while the connector is uncoupled from the light fixture, and designate the range to the fixture control circuitry while the connector is coupled to the light fixture.

Abstract: An image sensor includes an active pixel array including a number of pixels and image sensor control circuitry configured to perform a read operation only on a subset of the pixels of the active pixel array such that pixels not in the subset remain inactive. By reading out only the subset of pixels in the active pixel array and keeping the remaining pixels inactive, the temperature of the active pixel array may be reduced compared to a conventional read out process, thereby reducing thermal noise in the resulting pixel data.

Abstract: An image sensor includes an active pixel array including a number of pixels and image sensor control circuitry configured to perform a read operation only on a subset of the pixels of the active pixel array such that pixels not in the subset remain inactive. By reading out only the subset of pixels in the active pixel array and keeping the remaining pixels inactive, the temperature of the active pixel array may be reduced compared to a conventional read out process, thereby reducing thermal noise in the resulting pixel data.

Abstract: The present disclosure describes methods of determining a treatment protocol for and/or a prognosis for a subject suspected of or at risk of suffering from a neurologic disease or disorder, including such diseases and disorders that involve motor neuron function such as ALS. The methods comprise detecting the presence of a chitinase protein in a biological sample.

Abstract: A distributed, parallel, image capture and processing architecture provides significant advantages over prior art systems. A very large array of computational circuits—in some embodiments, matching the size of the pixel array—is distributed around, within, or beneath the pixel array of an image sensor. Each computational circuit is dedicated to, and in some embodiments is physically proximal to, one, two, or more associated pixels. Each computational circuit is operative to perform computations on one, two, or more pixel values generated by its associated pixels. The computational circuits all perform the same operation(s), in parallel. In this manner, a very large number of pixel-level operations are performed in parallel, physically and electrically near the pixels.

Abstract: The present disclosure describes methods of determining a treatment protocol for and/or a prognosis for a subject suspected of or at risk of suffering from a neurologic disease or disorder, including such diseases and disorders that involve motor neuron function. In certain aspects, methods are provided for determining a concentration of a one or more chitinase proteins in a biological fluid sample containing or suspected of containing chitinase protein.

Abstract: A distributed, parallel, image capture and processing architecture provides significant advantages over prior art systems. A very large array of computational 0 in some embodiments, matching the size of the pixel array—is distributed around, within, or beneath the pixel array of an image sensor. Each computational circuit is dedicated to, and in some embodiments is physically proximal to, one, two, or more associated pixels. Each computational circuit is operative to perform computations on one, two, or more pixel values generated by its associated pixels. The computational circuits all perform the same operation(s), in parallel. In this manner, a very large number of pixel-level operations are performed in parallel, physically and electrically near the pixels.

Abstract: A fixture configuration module comprises a connector configured to be removably coupled with a light fixture. The fixture configuration module also comprises fixture control circuitry communicatively coupled to the connector and configured to control the light fixture to produce light in accordance with a range of a lighting parameter. The range includes at least a subset of values supported by the light fixture for producing light. The fixture configuration module further comprises range control circuitry communicatively coupled to the fixture control circuitry and configured to wirelessly receive the range at least while the connector is uncoupled from the light fixture, and designate the range to the fixture control circuitry while the connector is coupled to the light fixture.

Abstract: A lighting fixture includes a fixture body, a lighting bay, a light source, and an auxiliary bay. The lighting bay is in a first portion of the fixture body. The light source is in the lighting bay, and is configured to provide light suitable for general illumination. The auxiliary bay is adjacent to the lighting bay in a second portion of the fixture body. The auxiliary bay includes a mounting surface suitable for mounting an auxiliary device in the auxiliary bay and an auxiliary bay frame surrounding the auxiliary bay, which supports and therefore allows for the installation of a removable auxiliary bay cover over the auxiliary bay. Providing the auxiliary bay in the fixture body allows auxiliary devices to be installed in a ceiling without any changes to the ceiling.

Abstract: A fixture configuration module comprises fixture control circuitry and range control circuitry. The fixture control circuitry is configured to control a light fixture to produce light in accordance with a range of a lighting parameter. The range identifies at least a subset of values of the lighting parameter supported by the light fixture to produce light. The range control circuitry is communicatively coupled to the fixture control circuitry and comprises a mechanical switch. The range control circuitry is configured to designate the range to the fixture control circuitry in response to the mechanical switch being positioned into at least one of a plurality of switch positions into which the mechanical switch is positionable.

Abstract: An image sensor includes an active pixel array including a number of pixels and image sensor control circuitry configured to perform a read operation only on a subset of the pixels of the active pixel array such that pixels not in the subset remain inactive. By reading out only the subset of pixels in the active pixel array and keeping the remaining pixels inactive, the temperature of the active pixel array may be reduced compared to a conventional read out process, thereby reducing thermal noise in the resulting pixel data.

Abstract: A lighting fixture includes a fixture body, a lighting bay, a light source, and an auxiliary bay. The lighting bay is in a first portion of the fixture body. The light source is in the lighting bay, and is configured to provide light suitable for general illumination. The auxiliary bay is adjacent to the lighting bay in a second portion of the fixture body. The auxiliary bay includes a mounting surface suitable for mounting an auxiliary device in the auxiliary bay and an auxiliary bay frame surrounding the auxiliary bay, which supports and therefore allows for the installation of a removable auxiliary bay cover over the auxiliary bay. Providing the auxiliary bay in the fixture body allows auxiliary devices to be installed in a ceiling without any changes to the ceiling.

Abstract: A distributed, parallel, image capture and processing architecture provides significant advantages over prior art systems. A very large array of computational circuits—in some embodiments, matching the size of the pixel array—is distributed around, within, or beneath the pixel array of an image sensor. Each computational circuit is dedicated to, and in some embodiments is physically proximal to, one, two, or more associated pixels. Each computational circuit is operative to perform computations on one, two, or more pixel values generated by its associated pixels. The computational circuits all perform the same operation(s), in parallel. In this manner, a very large number of pixel-level operations are performed in parallel, physically and electrically near the pixels.