Abstract: A method may include ingesting a plurality of sources files from a plurality of infrastructure assets; inputting the plurality of source files into a cognitive computing engine (CCE); receiving an output from the CCE, the output indicating a plurality of relationships between the infrastructure assets; and updating a data store based on the plurality of relationships.

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: Described herein are materials and methods of incorporating CLIP peptide into the peptide binding groove of HLA Class II antigens and using such HLA Class II antigens for the detection of alloantibodies.

Abstract: Disclosed is Crystal Form S4 of a fumarate salt of compound (I) represented by the following structural formula: (I) The molar ratio between compound (I) and fumaric acid is 1.0:1:0. Crystal Form S4, 5 characterized by an X-ray powder diffraction pattern which comprises peaks at 6.6°, 9.8°, 16.3°, 21.1°, 28.7°, and 30.2°±0.2 in 2?.

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: Described herein are materials and methods of incorporating CLIP peptide into the peptide binding groove of HLA Class II antigens and using such HLA Class II antigens for the detection of alloantibodies.

Abstract: A retention clamp includes a shaft having a stop member and a first threaded portion, the first threaded portion including a left hand thread. A clamping member is threadably connected to the first threaded portion. A biasing member positioned between the stop member and the clamping member transfers a rotational force applied to the shaft to the clamping member to rotate the clamping member into an engagement position. An indexing member can be slidably received over the first threaded portion and positioned between the stop member and the clamping member. The indexing member is frictionally engageable with the clamping member so indexing member rotation rotates the clamping member. Both the indexing member and the clamping member can include meshable ratchet teeth to assist clamping member rotation. Legs extending transversely from the biasing member can positively engage the stop portion and the indexing member.

Abstract: A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit of a wild type heteromeric cytotoxic protein to create a library of microorganism clones producing mutant proteins which are then screened for their ability to specifically bind to and kill a target cell.

Abstract: A retention clamp includes a shaft having a stop member and a first threaded portion, the first threaded portion including a left hand thread. A clamping member is threadably connected to the first threaded portion. A biasing member positioned between the stop member and the clamping member transfers a rotational force applied to the shaft to the clamping member to rotate the clamping member into an engagement position. An indexing member can be slidably received over the first threaded portion and positioned between the stop member and the clamping member. The indexing member is frictionally engageable with the clamping member so indexing member rotation rotates the clamping member. Both the indexing member and the clamping member can include meshable ratchet teeth to assist clamping member rotation. Legs extending transversely from the biasing member can positively engage the stop portion and the indexing member.

Abstract: An interbody device for the fixation and support of adjacent bone bodies includes a body for implantation at a location between the two vertebrae and one or more protrusions extending from the body. The protrusion(s) are configured for engagement with one of the vertebrae upon implantation and for progressive penetration into the vertebra over a period of time subsequent to the implantation.

Abstract: The magnitude of the force that can be created when each of a plurality of bone elements, such as the vertebrae of the human spine, is brought into alignment and stabilized by a corrective appliance comprising bone fasteners, such as pedicle screws attached to the bone elements, and one or more aligning devices, such as fixation rods, is measured and constrained. The force required to bring the bone element into alignment with the aligning device is maintained below a selected magnitude. In some instances, in order to maintain the magnitude of the force below the selected magnitude, it may be necessary to make an adjustment so that the bone fastener can be secured to a respective aligning device without increasing the force to or beyond the selected magnitude.

Abstract: A bone fastener assembly, comprising a bone fastener, an adjusting member and a securing fastener is provided for fastening an appliance to a bone body so that a plurality of the bone fastener assemblies and the appliance constitute an apparatus that acts to retain a plurality of bone bodies in a desired spatial relationship. Each bone fastener has an attaching portion for attaching the bone fastener to a bone or bone part, a supporting portion for supporting the adjusting member for universal movement relative to the supporting portion, and a securing portion for securing the bone fastener to the securing fastener. The securing fastener has a first end that passes through an aperture in the appliance and an opening in the adjusting member and is secured to the securing portion of the bone fastener. A second end of the securing fastener has a bearing surface that adjustably bears against the appliance in opposition to an engaging surface of the adjusting member that engages the appliance.

Abstract: The invention is directed to a bone plate system. The bone plate system comprises a base plate having two generally parallel elongated screw slots extending therethrough. Two bone screws are provided that are capable of securing the base plate to a bone by insertion through the screw slots into the bone. Each bone screw has a screw head and a threaded portion extending therefrom. An interference device is attached to the base plate and retains the bone screws while permitting the bone screws to toggle and to controllably slide in the screw slots of the base plate. This design is particularly useful for joining adjacent vertebral bodies, as it permits controlled settling of the vertebral bodies, thereby enhancing the healing process.

Abstract: An interbody device for the fixation and support of adjacent bone bodies includes a body for implantation at a location between the two vertebrae and one or more protrusions extending from the body. The protrusion(s) are configured for engagement with one of the vertebrae upon implantation and for progressive penetration into the vertebra over a period of time subsequent to the implantation.

Abstract: A curette including a cylindrical handle, having a longitudinal axis, and a shaft, having a longitudinal axis. The shaft is attached to the cylindrical handle at a first end of the shaft, such that the longitudinal axis of the shaft is parallel to, but not collinear with, the longitudinal axis of the cylindrical handle. A tip is included in a second end of the shaft.

Abstract: This invention relates to an X-ray film holder and more particularly to a cassette for holding low dosage, soft tissue, X-ray film, for use in association with a mammography machine.