Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof. Further disclosed a method for treating a disease or condition mediated, at least in part, by NLRP3, the method comprising administering an effective amount of the pharmaceutical composition, to a subject in need thereof.

Abstract: An immersion cooling system includes an immersion tank defining an immersion chamber therein, an immersion working fluid, an energy source, an optical sensor, and a microcontroller. The immersion working fluid is positioned at least partially in the immersion chamber and the immersion working fluid has a liquid phase and a vapor phase. The energy source is positioned and oriented to direct an infrared beam through a portion of the vapor phase with a beam path and path length. The optical sensor is positioned in the beam path. The microcontroller is configured to determine vapor concentration in the immersion chamber based at least partially on data from the path length, the optical sensor, and the energy source.

Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Abstract: The present disclosure relates to a carbon capture adapter that may attach to high air flow locations. A carbon capture adapter may utilize the air flow of a high air flow location to allow for capture of unfiltered air, allowing for carbon removal and the scrubbing of the unfiltered air. The carbon capture adapter may comprise carbon sensors that may detect carbon levels of the air before and after the carbon has been scrubbed or removed from the ambient air. The carbon capture adapter may capture and transform the carbon into secondary substances that may be useful unto itself. The carbon capture adapter will have all inputs, outputs, processes, and flows that meet all aspects of a closed loop system that is specifically designed for CCS. The carbon capture adapter may be at least temporarily secured to at least one portion of a vehicle.

Abstract: A firearm synchronized discharge device for facilitating a synchronized discharge of two or more firearms are described together with associated systems, firearms and methods. The device includes an actuator for engaging with a movable trigger of a first firearm, a sensor configured to generate a signal indicative of a force applied to the trigger and a first controller operatively coupled to the sensor and to the actuator. The actuator is configurable between a first configuration that prevents movement of the trigger toward a firearm-discharge position of the trigger, and a second configuration that permits movement of the trigger toward the firearm-discharge position of the trigger. When the force meets a criterion and the one or more other firearms are ready for discharge, the actuator is caused to transition from the first configuration to the second configuration to permit actuation of the trigger and discharge of the firearm.

Abstract: In one embodiment, an apparatus for dispensing a liquid is disclosed. The apparatus can comprise a cap configured to connect to a container body having a chamber for containing the liquid. The cap can comprise a pour aperture through which the liquid exits the apparatus. The cap can comprise a pour lid configured to open and close the pour aperture. The cap can comprise a cap vent configured to allow air to flow from the outside environs into the chamber of the container body when the cap is connected to the container body.

Abstract: As an example, a walker includes a first leg pair, a second leg pair and a cross beam connecting the first and second leg pairs in a parallel, spaced apart relationship. Each leg pair includes a U-shaped tube defining a front leg and a rear leg. A front strut is telescopically movable within the front leg and extends outwardly therefrom. A rear strut is telescopically movable within the rear leg and extends outwardly therefrom. A mechanical linear actuator includes a rotating element adapted to rotate relative to at least one of the front leg or the rear leg. The rotating element includes an interface with a track on the respective strut relative to which the rotating element rotates, whereby rotational motion of the rotating element translates to corresponding linear motion of the strut.

Abstract: Embodiments of the invention provide a packaging tray for use in packaging items, the tray having a first region having a cross-section which defines a concave surface having one or more cross-sections suitable to receive an item and a second region having a cross-section which is substantially straight. Embodiments provide a process in which tray may be loaded by depositing kiwi fruit and then agitated to settle and align the kiwifruit in the concave sections assisted with the straight sections providing space for movement of the kiwifruit laterally to the concave sections and directing the kiwifruit of the agitated tray towards the concave section. The tray is wrapped after the items are deposited and the wrapped tray is loaded into a box with settled items and loads the wrapped tray into a box.

Abstract: This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4 -yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

Abstract: The present disclosure relates to a carbon capture adapter that may attach to high air flow locations. A carbon capture adapter may utilize the air flow of a high air flow location to allow for capture of unfiltered air, allowing for carbon removal and the scrubbing of the unfiltered air. The carbon capture adapter may comprise carbon sensors that may detect carbon levels of the air before and after the carbon has been scrubbed or removed from the ambient air. The carbon capture adapter may capture and transform the carbon into secondary substances that may be useful unto itself. The carbon capture adapter will have all inputs, outputs, processes, and flows that meet all aspects of a closed loop system that is specifically designed for CCS. The carbon capture adapter may be at least temporarily secured to at least one portion of a vehicle.

Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Abstract: This Application regards a system for continuously monitoring a workcell during operation of industrial machinery. The system includes a safety system, a monitoring system, and a controller. The safety system includes a sensor and supporting software or hardware for acquiring image data associated with the workcell. The monitoring system is for detecting a parameter value associated with the safety system. And the controller is configured to determine whether the image data is valid based at least in part on the detected parameter value, and cause an alert to be issued responsive to determining that the image data is invalid.

Abstract: In one embodiment, an apparatus for dispensing a liquid is disclosed. The apparatus can comprise a cap configured to connect to a container body having a chamber for containing the liquid. The cap can comprise a pour aperture through which the liquid exits the apparatus. The cap can comprise a pour lid configured to open and close the pour aperture. The cap can comprise a cap vent configured to allow air to flow from the outside environs into the chamber of the container body when the cap is connected to the container body.

Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Abstract: Systems and methods for continuously monitoring a workcell during operation of industrial machinery are disclosed. The system may comprise a safety system that includes at least one sensor and supporting software and/or hardware for acquiring image data associated with the workcell; a monitoring system for detecting a parameter value associated with the safety system; and a controller configured to determine a status of the safety system based at least in part on the detected parameter value and cause an alert to be issued if the status of the safety system does not satisfy a target objective.

Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

Abstract: Methods of filling wordline features of 3D NAND structures with tungsten include treating a conformal tungsten with nitrogen trifluoride (NF3). The NF3 treatment is preferential to the openings of the wordline features relative to the interiors of the wordline features. The treatment etches tungsten and inhibits subsequent deposition on the treated surfaces. Subsequent deposition is selective to the interior of the wordline features allowing non-conformal, inside-out deposition. The NF3 may be delivered from a gas zone that is isolated from tungsten deposition gases. The NF3 may be delivered from a charge volume to facilitate top-to-bottom uniform treatment of a 3D NAND structure. Apparatuses for filling wordline features include separate gas zones.

Abstract: The press wheel has instrumentation associated therewith detecting a rolling of the wheel over a planted set. A computing device is connected to the instrumentation and to the speed monitoring device of the planter. The computing device determines spacings between planted sets. The data obtained is real-time data and is readily available to the operator of the planter so that the speed of the planter can be adjusted on the fly to maintain an ideal set spacing. The press wheel has a soft, smooth, flexible and stretchable rolling surface capable of deforming over a planted set and detecting an imprint of the planted set in the surface thereof, without damaging the planted set. A contact signature of the rolling of the press wheel over a planted set shows that the “rolling on” of the press wheel over a planted set is as smooth as the “rolling away” from the planted set.