Patents by Inventor Robert A Daines

Robert A Daines has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole compounds useful for treating bacterial infections
    Patent number: 6469046
    Abstract: This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH useful in treating bacterial infections.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: October 22, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert A. Daines, Kelvin C. Sham
  • Indolecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
    Patent number: 6214856
    Abstract: Pharmaceutical compositions and methods of inhibiting calpain using novel indolecarboxamides are disclosed.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: April 10, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert A Daines, Kelvin Kin-Cheong Sham
  • Quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
    Patent number: 6100267
    Abstract: Pharmaceutical compositions and methods of inhibiting calpain using novel quinoline- or naphthatenecarboxamides are disclosed.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: August 8, 2000
    Assignees: SmithKline Beecham Corporation, Cephalon, Inc.
    Inventors: Robert A Daines, William D Kingsbury, Israil Pendrak, John P Mallamo
  • Quinoline-containing .alpha.-ketoamide cysteine and serine protease inhibitors
    Patent number: 6083944
    Abstract: The present invention is directed to quinoline-containing .alpha.-ketoamide inhibitors of cysteine and serine proteases are disclosed. Methods for making these compounds, and methods for using the same are also disclosed.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: July 4, 2000
    Assignees: Cephalon, Inc., Smithkline Beecham Corp.
    Inventors: Sankar Chatterjee, John P. Mallamo, Derek Douglas Dunn, Kurt Allen Josef, Zi-Qiang Gu, Robert A. Daines, William Dennis Kingsbury, Israel Pendrak, Kelvin C. Sham
  • Pharmaceutical pyridine compounds
    Patent number: 5990314
    Abstract: This invention relates to a compound of formula I ##STR1## These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: November 23, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: Robert A. Daines
  • Process for making phenylthiomethylpyridinylalkenoates
    Patent number: 5700943
    Abstract: This invention relates to a process of making a compound of formula I ##STR1## where R.sub.1 contains an .alpha.,.beta.-unsaturated carbonyl group & R.sub.n is hydrogen or nonhydrogen radicals which do not have a functional group which interferes with the coupling reaction, which process comprises coupling a thiolphenol or phenylalkylmercaptan with a chloromethylpyridine in the presence of DBU under an inert atmosphere. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: December 23, 1997
    Assignee: SmithKline Beecham Corporation
    Inventor: Robert A. Daines
  • Pyridine compounds for treating leukotriene-related diseases
    Patent number: 5656636
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela Anne Chambers, Robert A. Daines, Dalia R. Jakas, William D. Kingsbury, Israil Pendrak
  • Pharmaceutical pyridine compounds
    Patent number: 5643914
    Abstract: This invention relates to a compound of formula 1 ##STR1## or an N-oxide, or a pharmaceutically acceptable salt, where A is CH.sub.2 and Z is S(O).sub.q where q is 0, 1 or 2, CH.sub.2, CHOH, CO, NR.sub.x, or O, orA is C.dbd.O and Z is NR.sub.x ;m is 0-5;R.sub.x is hydrogen or lower alkyl;R is C.sub.1 to C.sub.20 -aliphatic, unsubstituted or substituted five-membered heteroaryl-C.sub.1 to C.sub.10 -aliphatic-O--, unsubstituted or substituted phenyl-C.sub.1 to C.sub.10 -aliphatic where substituted p from the group consisting of lower alkoxy, lower alkyl, trihalomethyl, and halo, or R is C.sub.1 to C.sub.20 -aliphatic-O--, or R is unsubstituted or substituted phenyl-C.sub.1 to C.sub.10 -aliphatic-O-- where substituted phenyl has one or more radicals selected from the group consisting of lower alkoxy, lower alkyl, trihalomethyl, and halo;R.sub.1 is R.sub.4, --(C.sub.1 to C.sub.5 aliphatic)R.sub.4, --(C.sub.1 to C.sub.5 aliphatic)CHO, --(C.sub.1 to C.sub.5 aliphatic)CH.sub.2 OR.sub.5;R.sub.2 and R.sub.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: July 1, 1997
    Assignee: SmithKline Beecham Corporation
    Inventor: Robert A. Daines
  • Pyridine compounds for treating leukotriene-related diseases
    Patent number: 5633258
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: May 27, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela A. Chambers, Robert A. Daines, Dalia R. Jakas, William D. Kingsbury, Israil Pendrak
  • Pyridine compounds for treating leukotriene-related diseases
    Patent number: 5631262
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: May 20, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela A. Chambers, Robert A. Daines, Dalia R. Jakas, William D. Kingsbury, Israil Pendrak
  • Diphenyl-2-propenoates for treating diseases associated with leukotriene B4
    Patent number: 5569677
    Abstract: This invention relates to a compound of formula I ##STR1## where the several groups are defined herein. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 29, 1996
    Assignee: SmithKline Beecham Corporation
    Inventor: Robert A. Daines