Abstract: An outdoor power equipment having sitting configuration and standing configuration is presented herein. The outdoor power equipment can be transformed from the sitting configuration to the standing configuration and vice versa, allowing an operator to use the outdoor power equipment in either a sitting position or standing position. The sitting position can place the operator at least in part forward of a drive axis of the outdoor power equipment, whereas the standing position can place the operator at least in part coincident with or behind the drive axis. The outdoor power equipment can be electric powered in some aspects, with modular and replaceable battery packs.

Abstract: The invention relates to particular prodrugs of substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.

Abstract: The present invention relates to PDE1 inhibitory compounds useful in the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as, among others, Parkinson's disease, depression, narcolepsy, psychosis, damage to cognitive function, e.g., in schizophrenia, or disorders that may be ameliorated through enhanced progesterone-signaling pathway, as well as their use as pharmaceuticals and pharmaceutical compositions comprising them. Methods of making and methods of use related to such compounds are further described.

Abstract: The disclosure relates to the combination of inhibitors of phosphodiesterase 1 (PDE1) useful for the treatment of certain cancers or tumors, such as colon cancer. In another embodiment, the disclosure relates to the use of inhibitors of PDE1 and an optional antitumor agent for the treatment of certain cancers or tumors.

Abstract: A quick-release swivel latch may include male and female components configured to selectively connect to, swivel relative to, and detach from one another. The male component may include an arc slot and a central indent, while the female component may include outer surfaces that collectively form a chamber for receiving an insertable portion of the male component. The top surface of the female component may include a cantilever wall having a front lip and a central protrusion corresponding in shape, size, and/or arrangement to and configured to engage the arc slot and ball indent slot on the male component. These corresponding features, once engaged, may enable the male and female components to swivel in one or more dimensions relative to one another once connected, and a user to pull up on the cantilever wall to quickly disengage the male and female components.

Abstract: A washing toilet seat assembly includes a toilet seat and a housing configured to be coupled to a toilet bowl to support the toilet seat about a pivot axis. The housing includes a cartridge interface and a cover moveable between an open position allowing access to the cartridge interface and a closed position blocking access to the cartridge interface. The washing toilet seat assembly further includes a cartridge removably coupled to the cartridge interface, the cartridge including a dispensable solution, and a spray wand moveably supported by at least one of the toilet seat or the housing. The spray wand is in fluid communication with the cartridge to dispense the dispensable solution, and the spray want is configured to dispense the dispensable solution during operation of the washing toilet seat assembly as a user sits on the toilet seat.

Abstract: A method, system, apparatus, and/or device to determine a condition of a user using a wearable device with a miniaturized spectrometer. The method, system, apparatus, and/or device may include: a band configured to extend at least partially around a body part of a user, the body part comprising an internal feature within the body part; a light source embedded in the band, where the light source is configured to emit light into the body part as the user wears the band; a collimator; an optical filter; and an optical sensor, where the collimator, optical sensor, or the optical filter are arranged together to form a stack embedded in the band.

Abstract: Compounds that inhibit phosphodiesterase 1 (PDE1) are useful to treat glaucoma or elevated intraocular pressure. The PDE1 inhibitors may be administered as monotherapy or in combination with additional intraocular-pressure lowering agents. In addition, the invention provides ophthalmic compositions comprising PDE 1 inhibitors and optionally one or more additional intraocular pressure-lowering agents. Topical and systemic therapy may be used.

Abstract: The present disclosure provides numerous applications for the use of liquid crystal polarization gratings (LCPGs) to controllably steer light. When combined with an image sensor, light generated or reflected from different fields of view (FOV) can be steered, allowing an increase in the FOV or the resolution of the image. Further, the LCPG can stabilize the resulting image, counteracting any movement of the image sensor. The combination of LCPGs and liquid crystal waveguides (LCWGs) allows fine deflection control of light (from the LCWG) over a wild field of view (from the LCPG). Further applications of LCPGs include object tracking and the production of depth images using multiple imaging units and independently steered LCPGs. The LCPG may be used in controlling both the projection and reception of light.

Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.

Abstract: Remediating hemp oil includes controlling heat and oxygenation levels to reduce the relative weight percentage of THC while mitigating the conversion of other cannabinoids to other compounds. The method may include bubbling air, oxygen, or another oxygen-containing gas into a reactor while maintaining the temperature of the hemp oil.

Abstract: A computer-implemented method performed at a user device for obtaining health-related data is disclosed. The method comprises receiving, over a communications network, a data collection configuration from a health monitoring system, the data collection configuration comprising schedule data defining a schedule of data collection activities to be performed at the user device, each data collection activity for acquiring at the user device respective health-related data. Based on the schedule data, a target time at which each data collection activity is to be performed is determined; and the data collection activities are initiated at the user device in accordance with their respective determined target times to obtain health-related data for the data collection activities. Result data is then transmitted to the health monitoring system based on the obtained health-related data.

Abstract: A method is performed in a health study management system for collecting health-related data from user devices associated with participants in a health study. The health-related data may include: data indicative of user health, and source data from which data indicative of user health can be derived. The method includes receiving a health study configuration specifying data collection activities for a health study and scheduling information for the data collection activities. For each study participant, a data collection configuration is generated including schedule data based on the health study configuration for a user device associated with the study participant. The schedule data defines a schedule of data collection activities performed at the user device, each data collection activity obtaining respective health-related data for the study participant. The data collection configuration generated is transmitted to each user device to configure data collection activities to be performed at the user device.

Abstract: A computer-implemented method performed at a health study management system collects health-related data from data sources, including sensors monitoring system users. A modular data ingestion subsystem includes interface modules adapted to receive health-related data from a respective type of data source. A modular data processing subsystem includes processing modules, processing health-related data to determine derived health indicators. The system receives configuration information for a health study using the health study management system, the configuration information specifying data collection activities, for collecting respective health-related data. The data collection activities include sensor-based data collection activities associated with a sensor type for collecting sensor data, and processing collected sensor data. The data ingestion subsystem and data processing subsystem are configured for the health study.

Abstract: A computer-implemented method obtains health-related data at a user device, which runs a data collection application for obtaining health-related data. The data collection application supports data collection in: a sensor-based data collection mode for receiving health-related data from user device sensors, a user data input mode for obtaining health-related data based on user input of a configurable set of health-related data values, and an interactive health assessment mode for executing configurable interactive assessments for obtaining health-related data based on user/device interaction. A health monitoring system sends a data collection configuration, which specifies data collection activities. Each data collection activity is associated with a data collection mode(s) and is performed by the data collection application in accordance with the associated data collection mode to obtain health-related data.

Abstract: In variants, the method for automatic debris detection includes: determining a region image; optionally determining a parcel representation for the region image; generating a debris representation using the region image; generating a debris score based on the debris representation; and optionally monitoring the debris score over time.

Abstract: The invention relates to particular prodrugs of substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.

Abstract: A washing toilet seat assembly includes a toilet seat and a housing configured to be coupled to a toilet bowl to support the toilet seat relative to the toilet bowl. The housing includes a single cavity, a first cartridge interface structure positioned within the single cavity, and a second cartridge interface structure positioned within the single cavity. The first cartridge interface structure is configured to selectively receive a first cartridge. The second cartridge interface structure is configured to selectively receive a second cartridge. The washing toilet seat assembly includes a dispenser supported by at least one of the toilet seat or the housing. The dispenser is coupled to the first cartridge interface structure and the second cartridge interface structure. The dispenser is configured to dispense a first dispensable solution from the first cartridge. The dispenser is also configured to dispense a second dispensable solution from the second cartridge.

Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.

Abstract: An asphalt-based sealcoat composition comprising high levels of titanium oxide particles is provided. In some embodiments, a highly solar reflective asphalt-based sealcoat composition comprising high levels of titanium oxide particles is provided. In some embodiments, an asphalt-based sealcoat composition capable of reducing pollutants comprising high levels of titanium oxide particles is provided. In some embodiments, methods for preparing asphalt-based sealcoat compositions as well as their application to asphalt surfaces is provided.