Abstract: Radionuclide chelating compounds are provided for conjugation to targetting molecules such as proteins, peptides or antibodies. The resulting labelled targetting molecules may be used in diagnosis and therapy.

Abstract: An algorithm for detecting and tracking dynamically-related sets of unstable passive sonar signals is disclosed. The algorithm detects, enhances, tracks and displays both stable and unstable passive sonar signals, while organizing them into dynamically-related groups. The algorithm is implemented as part of a general purpose digital computer/peripheral system that performs:power spectrum analysis on the segmented time-waveform from the hydrophone,processing of the spectra for detection and enhancement of the signal by the novel algorithms of the present invention and other methods,formatting and displaying of the detected and enhanced signals.The algorithm of the present invention (the ABT, or Automatic Band Tracking algorithm) detects persistent signals having related features by means of correlation and enhances by mathematical integration (or smoothing) of the detected signals.

Abstract: A method and apparatus for suppressing the ventricular component from an atrial sensing lead used with a dual chamber cardiac pacer, thus obviating the need for an atrial sense refractory period to prevent oversensing of the ventricular interference. The invention utilizes an adaptive filter embodying the Widrow-Hoff least mean square (LMS) algorithm which is connected to receive signals from an endocardial lead having a bipolar ventricular electrode and a unipolar atrial electrode. The bipolar electrodes disposed in the ventricle are connected as the "input" X.sub.k signal to the LMS adaptive filter while the unipolar atrial electrode output is connected as the "desired" or reference signal d.sub.k.

Abstract: A tachyarrhythmia/fibrillation detector in which the Widrow-Hoff LMS algorithm is utilized for estimation of a transfer function. One or more LMS cancellers are placed between two separate sensing electrode pairs placed in or on the heart and by noting the convergence of the error signal or the lack thereof the type of tachyarrhythmia or a ventricular fibrillation condition can be discerned. With sinus rhythm, the error signal is small in power compared to the power of the desired response. With ventricular fibrillation, however the filter weights are unable to converge to cause the filter output signal to track desired signal and the filter output waveform becomes asynchronous with the desired response, yielding a detectably high error power.

Abstract: A method and apparatus for reliably detecting the P-wave component in a surface electrocardiograph. An adaptive Least Means Square filter is implemented in a programmed computer and the computer receives as its inputs a digitized version of the ECG waves picked up from two discrete locations on a subject's chest wall. The LMS adaptive filter functions to accommodate the energy component of the QRS complex thereby leaving the P-wave as the paramount signal component in the filter's "error" output.

Abstract: A method for automatically detecting P-waves in a continuous electrocardiograph signal stream irrespective of the presence of P-R disassociation wherein the lower energy P-wave can meld into the higher energy R-wave. In accordance with the invention, the ECG signal stream is digitized and fed to a computer programmed to perform signal processing operations thereon. First, a basic QRS morphologic prototype is developed through coherent-averaging of a plurality of QRS complexes appearing in the signal stream. Once the prototype is established, it is aligned with the incoming ECG signal stream where a recognizable similarity exists. The prototype is multiplied by a function comprising a "window" to smooth it to zero at its right and left edges while preserving essential center shape. The resulting windowed prototype is then scaled to match in amplitude or energy content the ECG signal stream at the points of alignment.