Patents by Inventor Robert A. Figler

Robert A. Figler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20220298487
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: April 26, 2021
    Publication date: September 22, 2022
    Inventors: Brian R. WAMHOFF, Brett R. BLACKMAN, Robert A. FIGLER, Daniel G. GIOELI, Michael B. SIMMERS
  • METHODS OF TREATING ORGANIC ACIDEMIAS
    Publication number: 20220142955
    Abstract: The present disclosure relates to methods of treating organic acidemias. In some embodiments, the methods comprise reducing propionyl-CoA, isovaleryl-CoA and methylmalonyl-CoA production, and various related metabolites, in a subject in need thereof.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 12, 2022
    Inventors: Brian WAMHOFF, John REARDON, Robert FIGLER
  • In vitro model for a tumor microenvironment
    Patent number: 11008549
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: May 18, 2021
    Assignee: Hemoshear, LLC
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20200010809
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: February 22, 2019
    Publication date: January 9, 2020
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • In vitro model for a tumor microenvironment
    Patent number: 10221394
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: March 5, 2019
    Assignee: HemoShear, LLC
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20180016557
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: April 10, 2017
    Publication date: January 18, 2018
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • In vitro model for a tumor microenvironment
    Patent number: 9617521
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: April 11, 2017
    Assignee: HemoShear, LLC
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20150111240
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 23, 2015
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • METHOD TO TREAT SICKLE CELL DISEASE
    Publication number: 20080009460
    Abstract: The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount amount of an A2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., rolipram).
    Type: Application
    Filed: February 9, 2007
    Publication date: January 10, 2008
    Inventors: Joel Linden, Kori Wallace, Robert Figler, Jayson Rieger
  • 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF
    Publication number: 20070232559
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Application
    Filed: March 26, 2007
    Publication date: October 4, 2007
    Inventors: Joel Linden, Jayson Rieger, Timothy Macdonald, Gail Sullivan, Lauren Murphree, Robert Figler
  • 2-Polycyclic propynyl adenosine analogs having A2A agonist activity
    Publication number: 20060217343
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: August 2, 2005
    Publication date: September 28, 2006
    Inventors: Jayson Rieger, Joel Linden, Timothy Macdonald, Gail Sullivan, Lauren Murphree, Robert Figler, Robert Thompson
  • 2-propynyl adenosine analogs with modifed 5'-ribose groups having A2A agonist activity
    Publication number: 20060040888
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: August 2, 2005
    Publication date: February 23, 2006
    Inventors: Jayson Rieger, Joel Linden, Timothy Macdonald, Gail Sullivan, Lauren Murphree, Robert Figler
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Publication number: 20060040889
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: August 2, 2005
    Publication date: February 23, 2006
    Inventors: Jayson Rieger, Joel Linden, Timothy Macdonald, Gail Sullivan, Lauren Murphree, Robert Figler, Robert Thompson