Patents by Inventor Robert A. Floyd
Robert A. Floyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10555915Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC). Preferably, the compositions for treating AAT will be administered orally. However, other methods which deliver the compositions for treating AAT systemically to the body should work equally well.Type: GrantFiled: August 24, 2010Date of Patent: February 11, 2020Assignees: Hough Ear Institute, Oklahoma Medical Research FoundationInventors: Richard Dana Kopke, Robert A. Floyd
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Patent number: 10398659Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.Type: GrantFiled: April 12, 2018Date of Patent: September 3, 2019Assignee: OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Rheal A. Towner, Robert A. Floyd
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Patent number: 10111843Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: June 23, 2017Date of Patent: October 30, 2018Assignees: Hough Ear Institute, Oklahoma Medical Research FoundationInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner
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Publication number: 20180228744Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.Type: ApplicationFiled: April 12, 2018Publication date: August 16, 2018Inventors: Rheal A. TOWNER, Robert A. FLOYD
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Patent number: 10022346Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: January 27, 2017Date of Patent: July 17, 2018Assignees: Hough Ear Institute, Oklahoma Medical Research FoundationInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner
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Patent number: 9968569Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.Type: GrantFiled: October 13, 2016Date of Patent: May 15, 2018Assignee: OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Rheal A. Towner, Robert A. Floyd
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Publication number: 20170281583Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: June 23, 2017Publication date: October 5, 2017Applicants: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. KOPKE, Robert A. FLOYD, Rheal TOWNER
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Publication number: 20170224635Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC). Preferably, the compositions for treating AAT will be administered orally. However, other methods which deliver the compositions for treating AAT systemically to the body should work equally well.Type: ApplicationFiled: April 24, 2017Publication date: August 10, 2017Applicants: Hough Ear Institute, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. Kopke, Robert A. Floyd
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Publication number: 20170202797Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: January 27, 2017Publication date: July 20, 2017Applicants: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. KOPKE, Robert A. FLOYD, Rheal TOWNER
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Patent number: 9642823Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: February 18, 2016Date of Patent: May 9, 2017Assignees: Hough Ear Institute, Oklahoma Medical Research FoundationInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner
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Publication number: 20170027891Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.Type: ApplicationFiled: October 13, 2016Publication date: February 2, 2017Applicant: OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Rheal A. TOWNER, Robert A. FLOYD
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Patent number: 9474748Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.Type: GrantFiled: January 21, 2014Date of Patent: October 25, 2016Assignee: OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Rheal A. Towner, Robert A. Floyd
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Publication number: 20160158173Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: February 18, 2016Publication date: June 9, 2016Applicants: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. KOPKE, Robert A. FLOYD, Rheal TOWNER
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Patent number: 9289404Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprises 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: February 3, 2012Date of Patent: March 22, 2016Assignees: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner
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Publication number: 20150376251Abstract: A method is described for inducing formation of neurons from embryonal stem cells, by utilizing an exogenous ferritin-H inducer.Type: ApplicationFiled: March 2, 2015Publication date: December 31, 2015Inventors: Robert H. Broyles, Robert A. Floyd, Austin C. Roth, Visar Belegu
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Publication number: 20140200234Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.Type: ApplicationFiled: January 21, 2014Publication date: July 17, 2014Applicant: OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Rheal A. TOWNER, Robert A. FLOYD
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Publication number: 20140187631Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprises 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: February 3, 2012Publication date: July 3, 2014Inventors: Richard D. Kpoke, Robert A. Floyd, Rheal Towner
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Patent number: 8633249Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.Type: GrantFiled: September 2, 2009Date of Patent: January 21, 2014Assignee: Oklahoma Medical Research FoundationInventors: Rheal A. Towner, Robert A. Floyd
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Publication number: 20130225694Abstract: Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compositions, as well as pharmaceutical and ophthalmic compositions containing same, are disclosed.Type: ApplicationFiled: February 25, 2013Publication date: August 29, 2013Applicants: Oklahoma Medical Research Foundation, The Board of Regents of the University of OklahomaInventors: Robert E. Anderson, Nawajes A. Mandal, Jian-Xing Ma, Gennadiy Moiseyev, Robert A. Floyd
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Patent number: 8420595Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free radical scavengers, such as edaravone, resveratrol, ebselen and iron chelator and compounds from the family of antioxidant compounds including, but not limited to, N-acetylcysteine (NAC), Acetyl-L-Carnitine (ALCAR), glutathione monoethylester, ebselen, D-methionine and carbamathione. The compositions of the current invention may be delivered by injections or orally.Type: GrantFiled: July 25, 2007Date of Patent: April 16, 2013Assignee: Oklahoma Medical Research FoundationInventors: Richard Dana Kopke, Robert A. Floyd