Abstract: The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 ?M, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.

Abstract: The specification relates to conjugates comprising a linker of Formula (IMA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

Abstract: The specification relates to conjugates comprising a linker of Formula (IA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

Abstract: The specification relates to conjugates comprising a linker of Formula (ICA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

Abstract: A graphics pipeline cache reconstruction operation is implemented to reconstruct one or more graphics pipeline caches for a current client gaming session based on one or more pipeline structures. The pipeline structures each represent a graphical object rendered during a respective previous client gaming session and are used to reconstruct one or more graphics pipeline caches that include graphics pipeline cache objects related to the graphical objects of the pipeline structures. These graphics pipeline cache objects are used to initialize one or more graphics pipelines used to render the graphical objects in a gaming application for a current client gaming session.

Abstract: The specification relates to conjugates comprising a linker of Formula (IA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

Abstract: The specification relates to conjugates comprising a linker of Formula (ICA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

Abstract: The present disclosure relates to methods and kits for the diagnosis and treatment of autism spectrum disorder (ASD) in human subjects. The disclosure also relates to computer-implemented methods for diagnosing and treating ASD. Current diagnostic protocols are mainly limited to behavioural examination as laboratory findings have been consistently abnormal in ASD. No currently reported biomarker holds promise as early developmental screen or an early diagnostic or prognostic tool for pediatric settings at young ages from birth through early childhood when these clinical tools are most needed. With the present disclosure, metabolomic profiles, protein profiles and combinations thereof for ASD are identified in the subject having ASD.

Abstract: A graphics pipeline cache reconstruction operation is implemented to reconstruct one or more graphics pipeline caches for a current client gaming session based on one or more pipeline structures. The pipeline structures each represent a graphical object rendered during a respective previous client gaming session and are used to reconstruct one or more graphics pipeline caches that include graphics pipeline cache objects related to the graphical objects of the pipeline structures. These graphics pipeline cache objects are used to initialize one or more graphics pipelines used to render the graphical objects in a gaming application for a current client gaming session.

Abstract: Increased regulation reflects individuals' growing concerns about sharing their health data. But, if left unaddressed, these regulations act as a barrier to healthcare researchers and providers accessing the real-world health data they need for AI-powered health advances. Accordingly, the inventors have established a decentralized ledger based self-sovereign data management platform for individuals. Via the platform an individual is provided a personalized health wallet to supporting self-sovereign data management giving them control and custody of their own health data. The platform provides for data credentialing to ensure quality and support of verifiable claims, e.g., about an individuals' consent to share and/or a third party research project having ethics approval, zero-knowledge proofs to protect individual privacy and promote secure data sharing, and support for privacy-preserving audit, accountability and compliance relating individuals' consent and data sharing.

Abstract: A graphics pipeline cache reconstruction operation is implemented to reconstruct one or more graphics pipeline caches for a current client gaming session based on one or more pipeline structures. The pipeline structures each represent a graphical object rendered during a respective previous client gaming session and are used to reconstruct one or more graphics pipeline caches that include graphics pipeline cache objects related to the graphical objects of the pipeline structures. These graphics pipeline cache objects are used to initialize one or more graphics pipelines used to render the graphical objects in a gaming application for a current client gaming session.

Abstract: A graphics pipeline cache reconstruction operation is implemented to reconstruct one or more graphics pipeline caches for a current client gaming session based on one or more pipeline structures. The pipeline structures each represent a graphical object rendered during a respective previous client gaming session and are used to reconstruct one or more graphics pipeline caches that include graphics pipeline cache objects related to the graphical objects of the pipeline structures. These graphics pipeline cache objects are used to initialize one or more graphics pipelines used to render the graphical objects in a gaming application for a current client gaming session.

Abstract: A real-time aircraft bird congestion indicator system for measuring congestion in an airspace between aircraft and birds uses one or more radars to continuously survey an airspace around an airport or aerodrome and continuously generate aircraft tracks and bird tracks in the airspace. A congestion processor connected to the radar(s) receives the aircraft and bird tracks and processes them to periodically generate a congestion indicator that measures the congestion in the airspace. A display processor connected to the congestion processor receives the congestion indicator which is updated periodically by the congestion processor and displays the congestion indicator to a user, generates an alert if the congestion indicator falls outside set operating limits, and/or sends the congestion indicator or alert to another system.

Abstract: A real-time aircraft bird congestion indicator system for measuring congestion in an airspace between aircraft and birds uses one or more radars to continuously survey an airspace around an airport or aerodrome and continuously generate aircraft tracks and bird tracks in the airspace. A congestion processor connected to the radar(s) receives the aircraft and bird tracks and processes them to periodically generate a congestion indicator that measures the congestion in the airspace. A display processor connected to the congestion processor receives the congestion indicator which is updated periodically by the congestion processor and displays the congestion indicator to a user, generates an alert if the congestion indicator falls outside set operating limits, and/or sends the congestion indicator or alert to another system.

Abstract: A real-time aircraft bird congestion indicator system for measuring congestion in an airspace between aircraft and birds uses one or more radars to continuously survey an airspace around an airport or aerodrome and continuously generate aircraft tracks and bird tracks in the airspace. A congestion processor connected to the radar(s) receives the aircraft and bird tracks and processes them to periodically generate a congestion indicator that measures the congestion in the airspace. A display processor connected to the congestion processor receives the congestion indicator which is updated periodically by the congestion processor and displays the congestion indicator to a user, generates an alert if the congestion indicator falls outside set operating limits, and/or sends the congestion indicator or alert to another system.

Abstract: In one aspect, the present disclosure may provide devices or systems configured to receive indications of geographic areas, each corresponding to distribution networks, and determine whether the distribution networks overlap. The processor(s) may also be configured to receive parameter value(s) obtained by a device within one distribution network at a location within an overlapping area, and cause device(s) within another distribution network to modify operation based on the parameter value(s). In another aspect, the present disclosure may provide devices that include a voltage sensor to measure a voltage of a power distribution network at a power consumption location that corresponds to the device. The device may be configured to provide at least one cable service to the power consumption location via a cable television (CATV) distribution network and output an indication the measured voltage value.

Abstract: The technology relates to generating a wireless network access point model for determining locations within an area. In one example, a plurality of scan vectors, each scan vector representing a set of signal strengths for a set of wireless network access point identifiers and being associated with a location within the area at which a mobile device moving through the area measured the set of signal strengths are received. A set of clusters is generated by iterating through a split phase until the number of clusters in the set of clusters equals a maximum number of clusters or there are no bad scan vectors identified. A bad scan vector may include a vector having a vector difference from a center of a cluster to which that vector is assigned is less than a minimum similarity value. The set of cluster is then used to generate the model of the area.

Abstract: The technology relates to generating a wireless network access point model for determining locations within an area. In one example, a plurality of scan vectors, each scan vector representing a set of signal strengths for a set of wireless network access point identifiers and being associated with a location within the area at which a mobile device moving through the area measured the set of signal strengths are received. A set of clusters is generated by iterating through a split phase until the number of clusters in the set of clusters equals a maximum number of clusters or there are no bad scan vectors identified. A bad scan vector may include a vector having a vector difference from a center of a cluster to which that vector is assigned is less than a minimum similarity value. The set of cluster is then used to generate the model of the area.

Abstract: A real-time aircraft bird congestion indicator system for measuring congestion in an airspace between aircraft and birds uses one or more radars to continuously survey an airspace around an airport or aerodrome and continuously generate aircraft tracks and bird tracks in the airspace. A congestion processor connected to the radar(s) receives the aircraft and bird tracks and processes them to periodically generate a congestion indicator that measures the congestion in the airspace. A display processor connected to the congestion processor receives the congestion indicator which is updated periodically by the congestion processor and displays the congestion indicator to a user, generates an alert if the congestion indicator falls outside set operating limits, and/or sends the congestion indicator or alert to another system.

Abstract: In one aspect, the present disclosure may provide devices or systems configured to receive indications of geographic areas, each corresponding to distribution networks, and determine whether the distribution networks overlap. The processor(s) may also be configured to receive parameter value(s) obtained by a device within one distribution network at a location within an overlapping area, and cause device(s) within another distribution network to modify operation based on the parameter value(s). In another aspect, the present disclosure may provide devices that include a voltage sensor to measure a voltage of a power distribution network at a power consumption location that corresponds to the device. The device may be configured to provide at least one cable service to the power consumption location via a cable television (CATV) distribution network and output an indication the measured voltage value.