Abstract: A display system configured to communicate tissue proximity data from a plurality of electrodes includes a display. The display outputs a circular graphical representation. The circular graphical representation includes a plurality of color areas forming a first circular shape. Each of the color areas communicate a categorized value for a respective electrode indicative of tissue proximity for the respective electrode. A plurality of graph areas form a second circular shape. Each of the graph areas communicate a relative value for the respective electrode indicative of the tissue proximity for the respective electrode.

Abstract: The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

Abstract: The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone.

Abstract: The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

Abstract: The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone.

Abstract: The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

Abstract: Devices, systems, and techniques for transitioning between different drug delivery sources or different drug concentrations may account for diffusion and mixing of drug within the fluid. In one example, a method may include determining a flow rate for a fluid to be delivered to a patient via a drug pump and a catheter in fluid communication with a reservoir of the drug pump. The fluid includes a drug. The method also includes determining a concentration profile of the drug delivered via the catheter, wherein the concentration profile identifies a volume of delivered fluid needed to achieve a target transition dose of the drug. The method further includes determining, by a processor and based on the flow rate and the concentration profile, an initial delivery period required to achieve the target transition dose by delivering the fluid at the flow rate.

Abstract: Devices, systems, and techniques for transitioning between different drug delivery sources or different drug concentrations may account for diffusion and mixing of drug within the fluid. In one example, a method may include determining a flow rate for a fluid to be delivered to a patient via a drug pump and a catheter in fluid communication with a reservoir of the drug pump. The fluid includes a drug. The method also includes determining a concentration profile of the drug delivered via the catheter, wherein the concentration profile identifies a volume of delivered fluid needed to achieve a target transition dose of the drug. The method further includes determining, by a processor and based on the flow rate and the concentration profile, an initial delivery period required to achieve the target transition dose by delivering the fluid at the flow rate.

Abstract: The present invention relates to a device to be integrated into an article of footwear, normally as, but not limited to, a shoe innersole or shoe midsole, to interact with the plantar surface of the wearer's foot, in the region of the foot's main first layer intrinsic muscles. The present invention produces benefits to address gait related issues associated with weakened foot structure and faulty gait biomechanics.

Abstract: The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

Abstract: A method operable to more accurately monitor the state and function of the cervix is provided. Embodiments of the present invention relate generally to detection of fluorescence from the female mammalian cervix. More particularly, embodiments of the present invention relate to predicting true term and preterm labor and delivery, characterizing the function and state of the cervix, and for assessing and monitoring the efficacy of treatments for the cervix. Embodiments of the present disclosure use light induced fluorescence (LIF) via a non-invasive optical probe to accurately and quantitatively measure changes in the cervical tissue during pregnancy and labor. As gestational age increases, the LIF decreases. Ideally, cervical collagen should be at a minimum just prior to delivery. The present invention can be used to monitor the state and function of the cervix during pregnancy, as well as efficacy of cervical treatments during pregnancy.

Abstract: A system and method for acquiring and processing abdominal EMG signals from a maternal patient to indicate when a maternal patient should push to progress the labor toward delivery. Raw abdominal EMG signals are acquired and processed in a central unit designed to isolate the patient and any internal circuitry from electrical shock. The central unit has a circuit board that amplifies and filters the EMG signal, then transmits the signal to an A/D converter, after which the digitized signal is transmitted to a computer for further processing and subsequent display of a signal representative of abdominal activity. The system may also acquire and process uterine EMG signals that can be evaluated in conjunction with the abdominal EMG signals.

Abstract: The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone.

Abstract: A system and method of acquiring and transmitting uterine EMG signals is disclosed, where a signal processing module processes incoming uterine EMG signals from a patient and wirelessly transmits a processed signal to an information relaying device. The information relaying device is then configured to download the processed signal and transmit the signal to a call center or health care facility for physician evaluation. The system is ambulatory, thus allowing the patient to record and transmit uterine EMG signals anywhere a satisfactory transmission may be made.

Abstract: A method and system to examine and measure the propagation velocity of electrical activity in pregnant patients, labor and non-labor patients at term and preterm, and non-pregnant patients, thereby providing valuable information regarding the state of a patient's uterus. The method can include obtaining uterine EMG signals from a series electrodes, processing the raw uterine EMG signal in a signal processing module and assessing the temporal interval between adjacent electrodes. The propagation velocity can then be estimated by averaging the time required for the uterine EMG signal to traverse a distance between adjacent electrodes.

Abstract: A system and method for acquiring and processing abdominal EMG signals from a maternal patient to indicate when a maternal patient should push to progress the labor toward delivery. Raw abdominal EMG signals are acquired and processed in a central unit designed to isolate the patient and any internal circuitry from electrical shock. The central unit has a circuit board that amplifies and filters the EMG signal, then transmits the signal to an A/D converter, after which the digitized signal is transmitted to a computer for further processing and subsequent display of a signal representative of abdominal activity. The system may also acquire and process uterine EMG signals that can be evaluated in conjunction with the abdominal EMG signals.

Abstract: A method operable to more accurately predict true preterm labor and delivery is provided. Trans-abdominal uterine electromyography (EMG) and power spectrum (PS) analysis can identify electrical signals characteristic of labor at term and preterm with relatively high positive and negative predictive values. The use of propagation velocity (PV) of uterine EMG signals may either be done independently or in conjunction with PS analysis. This method involves applying at least two pairs of electrodes to a maternal abdomen. The time associated with measuring a voltage spike of a propagating myometrial wave traveling through the pairs of electrodes allows the amount of time required for the propagating myometrial wave to transverse the distance between electrodes to be determined. With this information a propagation velocity (PV) of the propagating myometrial wave may be determined. This PV may be compared to a labor positive predictive value (PPV).

Abstract: The present invention relates to an insole, midsole or unified outsole-midsole-insole device for use with an article of footwear, displaying significant improvement over conventional similar insole type products through its ability to offer to the wearer an adjustable biofeedback component for the rehabilitation and strengthening of the foot's muscles, as well as an adjustable motion control component for the purpose of controlling the pronation and arch deflection of the human foot during gait. Through this means wearers of the device gradually strengthen their foot while simultaneously decreasing their dependence on secondary motion control structures.

Abstract: Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.

Abstract: Muscle cells and nerves of the uterus and cervix are treated with electrical pulses having selective parameters in order to stimulate or inhibit contraction thereof. Either a needle or probe is provided having stimulation electrodes thereon from which the treatment pulses emanate. In a further embodiment, patients are simultaneously treated with pharmacological agents in conjunction with the electrical treatment.