Abstract: The invention relates to devices and methods for detecting and identifying microorganisms comprising a porous body having regions of differing pore size, said regions being associated with different chromogens specific to enzymes produced by microorganisms. Devices and methods according to the present invention may be useful in the detection and identification of food and water borne microorganisms as well as in the detection of bacteria that may be associated with infection, such as urinary tract infection.

Abstract: A building comprising (a) a rectangular central structure having a horizontal roof section, a floor section and at least one support for the roof section, (b) two roof extensions each pivotally attached on either side of the roof section with an offset hinge such that each can pivot from a first, horizontal position to a second, vertical position, wherein in the first position the two roof extensions are offset vertically relative to the roof section, and (c) two floor extensions each pivotally attached on either side of the floor section such that each can pivot from a first, horizontal position to a second, vertical position, wherein during transport or storage of the building, the two roof extensions and two floor extensions are each located in the second, vertical position, the floor extensions being located interior to the roof extensions.

Abstract: A silicon integrated circuit device comprising a near intrinsic silicon substrate in which there are one or more ohmic contact regions. An insulating layer lies above the substrate, and on top of the insulating layer is a lower layer of one or more aluminium gates. The surface of each of the lower gates is oxidised to insulate them from an upper aluminium gate that extends over the lower gates.

Abstract: The invention is a method and system for providing trace data in a pipelined data processor. Aspects of the invention include providing a trace pipeline in parallel to the execution pipeline, providing trace information on whether conditional instructions complete or not, providing trace information on the interrupt status of the processor, replacing instructions in the processor with functionally equivalent instructions that also produce trace information and modifying the scheduling of instructions in the processor based on the occupancy of a trace output buffer.

Abstract: A rectilinear ion trap includes a first pair of spaced planar RF electrodes, mounted in parallel and a second pair of spaced planar electrodes, mounted in parallel and orthogonal to the first pair of electrodes. The configuration of the pairs of electrodes define an axial direction and a radial direction. The trap further includes an RF source that applies an RF voltage to at least one of the pairs of RF electrodes to generate RF fields to trap ions in the axial and radial directions.

Abstract: Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.

Abstract: A real time clock comprises a counter which stores a count value, the count value representing a time signal. The counter may be written, for example by a host processor (not shown), such that the time signal can be set to any desired value. The real time clock comprises a check register that stores a check value. The content of the check register (i.e. the check value) is modified each time a write operation is performed on the counter. For example, the content of the check register can be updated by a control signal each time a write operation is performed on the counter. The check value stored in the check register is used for determining whether a write operation performed on the counter is an authorized write operation or an unauthorized write operation. The check value may be incremented each time a write operation is performed, replaced with a new random number each time a write operation is performed, or a combination of both.

Abstract: A tilt-rotor aircraft (1) comprising a pair of contra-rotating co-axial tiltable rotors (11) on the longitudinal center line of the aircraft. The rotors (11) may be tiltable sequentially and independently. They may be moveable between a lift position and a flight position in front of or behind the fuselage (19).

Abstract: A sensor for measuring material properties such as the relaxation modulus of a material in situ and a method of measuring material properties of a material are disclosed. The sensor may be substantially embedded in the material, and includes a deformable driver. When actuated, the deformable driver may create a stress in the adjacent material. The movement or deformation of the driver may be measured with a sensing device, for example a strain gage mounted on a surface thereof. The stress in the adjacent material may be measured with a second sensing device, for example a pressure sensor. The measured movement and stress over a predetermined period of time may he used to determine the relaxation modulus of the material.

Abstract: The present invention relates to a bioactive glass comprising strontium and silicon dioxide, processes for the production of the bioactive glass and the use of the bioactive glass in medicine.

Abstract: Validation of at least some of a proposed semiconductor design layout is disclosed. According to one or more aspects of the present invention, a first voltage dependent design rule is applied to an edge of an area of the layout if the edge is not covered by a pseudo layer. A second voltage dependent design rule is, on the other hand, applied to the edge of the area if the edge is covered by the pseudo layer.

Abstract: A distal tibia plating system includes anterolateral and medial plates. The anterolateral plate includes a shaft with both threaded first fastener holes and compression slots along its length. The head includes a first row of four threaded fastener holes arranged transversely to the longitudinal axis, a non-threaded compression screw hole, and a plurality of distal tabs. Each tab includes a ring with a single threaded fastener hole and a bridge that couples the ring to the distal end of the plate. The bridge is configured to bend preferentially in a desired direction and to allow tab removal. The medial plate is a low profile plate including a shaft and a relatively enlarged distal head. Several fasteners can be used with the plates. A plate holder is provided to maneuver the plates subcutaneously.

Abstract: A polyaxial locking screw system includes a bone plate defining a plate hole with an inner spherical surface and a relatively harder split polyaxial bushing with a outer spherical surface provided within the plate hole for receiving a bone screw. In one embodiment, the plate is formed from titanium alloy, while the bushing is formed from a cobalt chrome alloy. The outer surface of the polyaxial bushing includes a plurality of spikes. When the screw is inserted into the bushing, since the bushing material is considerably harder than the plate material, the forceful expansion of the bushing during screw insertion causes the spikes to penetrate into the inner spherical surface of the hole, thereby increasing the frictional engagement of the bushing to the plate to lock the screw at a desired angle.

Abstract: This invention concerns interfacing to electronic circuits or systems operating at low temperature or ultra-low temperature using complementary metal-oxide semiconductor (CMOS) technology. Low temperature in this case refers to cryogenic temperatures in particular, but not exclusively, to the 4.2 K region. Ultra-low temperatures here refers to the sub-1 K range, usually accessed using dilution refrigerator systems. The electronic circuits comprise a controller (for writing and manipulation), an observer (for readout and measurement) circuits, or both, fabricated from ultra-thin silicon-on-insulator (SOI) CMOS technology.

Abstract: Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.

Abstract: The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.

Abstract: The present invention is directed to the upgrading of heavy petroleum oils of high viscosity and low API gravity that are typically not suitable for pipelining without the use of diluents. The method comprises introducing a particulate heat carrier into an up-flow reactor, introducing the feedstock at a location above the entry of the particulate heat carrier, allowing the heavy hydrocarbon feedstock to interact with the heat carrier for a short time, separating the vapors of the product stream from the particulate heat carrier and liquid and byproduct solid matter, collecting a gaseous and liquid product mixture comprising a mixture of a light fraction and a heavy fraction from the product stream, and using a vacuum tower to separate the light fraction as a substantially bottomless product and the heavy fraction from the product mixture.

Abstract: A catheter guidewire for facilitating introduction of a flexible catheter into the human body (e.g., into the bladder) has a proximal end having a first stiffness which is sufficient to facilitate guidance of a stiff plastic expansion sheath through the tissue. A distal end of the guide wire has a second stiffness, substantially less than the first stiffness, to avoid damage to internal walls of the bladder. Preferably, the guide wire incorporates an intermediate portion having a stiffness between the first stiffness value and the second stiffness value.

Abstract: A method of separating species in a mixture of molecules, particles or atoms and collecting the separated species is described. The method comprises the steps of converting by ionization the species in the mixture to gas phase ions, separating the gas phase ions according to their mass charge ratio and/or mobility and collecting the separated ions. The system includes ionizing means such as electrospray to form the gas phase ions. The gas phase ions are separated by filtering, or in time or in space and soft-landed for collection such as on a surface.

Abstract: A method of dynamically controlling open hole pressure within a wellbore having a drill string positioned therein. The method comprising the steps of pumping a fluid down the drill string, into an annulus formed by the drill string and the interior of the wellbore, and then subsequently up the annulus to the surface of the ground; selectively applying wellhead pressure to the annulus through selectively pumping an additional quantity of the fluid or a quantity of a secondary fluid across the annulus; and, controlling the application of wellhead pressure applied to the annulus by controlling one, or both, of (a) the operation of a wellhead pressure control choke, and (b) the flow rate of the additional quantity of fluid or the secondary fluid pumped across the annulus, to thereby maintain open hole pressure within a desired range.