Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.

Abstract: A product label printing and checking system, comprising data processing means configured to: control the printing of product labels; control the acquisition and reception of images of the printed labels by an image acquisition device such as an optical scanner; and check the printed labels for defects, wherein each printed label accords with a label format specification for that label, whereby the label has a common layout and comprises printed product-related information located in one or more regions on the label, wherein the data processing means includes a label checking module in which there is provided a reference image of the label, and the checking module is configured so that the acquired images are sequentially compared against the reference image according to pre-determined quality control indicators relating to the expected information content and location in the label regions, and wherein the label is flagged for review or rejection if it is non-compliant.

Abstract: The invention generally relates to methods of coupling a carbon containing moiety to an amine containing moiety.

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.

Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.

Abstract: The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS).

Abstract: The invention generally relates to mass spectrometry via frequency tagging.

Abstract: The present invention relates to a failsafe valve actuator (10) comprising a drive mechanism (12), a drive shaft (42) having a clutch (50) arranged adjacent to a threaded portion (44) of the drive shaft (42), and a clutch actuator (52) coupled to the clutch (50) and arranged to move the clutch (50) between an engaged position in which the clutch (50) engages with the threaded portion (44) of the drive shaft (42) and a disengaged position in which the clutch (50) is disengaged from the drive shaft (42). In response to energisation of the clutch actuator (52) the clutch (50) is moved to the engaged position such that threaded engagement between the drive shaft (42) and clutch (50) transfers rotational movement of the drive shaft (42) by the drive mechanism (12) into axial movement of the drive shaft (42) and holds the drive shaft (42) against a drive shaft bias member when the drive mechanism is inactive.

Abstract: Systems and methods for analysing a fluid including a fluid sample delivery application. The system includes a sensing element configured to respond to at least one analyte in a sample of fluid. A detector is provided, configured to sense the response to the analyte by the sensing element. The fluid sample delivery apparatus includes a dosage needle configured to deliver the sample of fluid to the sensing element, at least one pump configured to control flow of fluid through the dosage needle, and at least one actuator configured to move the dosage needle relative to the sensing element. At least one controller is provided, configured to control the at least one pump and the at least one actuator.

Abstract: The invention generally relates to systems including nanoelectrospray ionization emitters in a movable array format in which the emitters can be loaded, singly or simultaneously, through their narrow ends using a novel dip and go method based on capillary action, taking up sample from an array. The sample solutions in each emitter can be electrophoretically cleaned, singly or simultaneously, by creating an inductive electric field that moves interfering ions away from the narrow end of the capillary. Subsequent to cleaning, the emitters are supplied with an inductive electric field that causes electrospray into a mass spectrometer allowing mass analysis of the contents of the emitter.

Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.

Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.

Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

Abstract: The invention generally relates to systems and methods for increasing reaction yield. In certain embodiments, the invention provides systems for increasing a yield of a chemical reaction that include a pneumatic sprayer configured to generate a liquid spray discharge from a solvent. The solvent includes a plurality of molecules, a portion of which react with each other within the liquid spray discharge to form a reaction product. The system also includes a collector positioned to receive the liquid spray discharge including the unreacted molecules and the reaction product. The system also includes a recirculation loop connected from the collector to the pneumatic sprayer in order to allow the unreacted molecules and the reaction product to be recycled through the pneumatic sprayer, thereby allowing a plurality of the unreacted molecules to react with each other as the unreacted molecules cycle again through the system.

Abstract: Techniques for resolution-based manifest generation for adaptive bitrate video streaming are described. As one example, a computer-implemented method includes performing a first, convex hull optimization on a video file for a first device resolution, performing a second, convex hull optimization on the video file for a second, lower device resolution, generating a first video representation for a point on both the first, convex hull optimization and the second, convex hull optimization for the first device resolution and the second, lower device resolution, generating a second video representation for a point only on the second, convex hull optimization for the second, lower device resolution, receiving a request for a manifest for the video file from a client device at the second, lower device resolution, generating the manifest for the client device that identifies the first video representation and the second video representation, and sending the manifest to the client device.

Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

Abstract: A system for analyzing a fluid includes an in-line sensor configured to analyze a fluid flowing past the in-line sensor to determine at least one in-line value of a fluid parameter of the fluid across an event period, and a sample sensor configured to analyze a sample of fluid extracted from the flow of fluid during the event period, to determine sample value of the fluid parameter for the sample. At least one processor is provided, configured to determine a representative in-line value of the fluid parameter across the event period based at least in part on the at least one in-line value, and determine an overall representative value of the fluid parameter across the event period based on the representative in-line value, the sample value for the sample, and one or more of the in-line values corresponding to the time of extracting the sample, wherein determination of the overall representative value is based on an error correction value determined for the in-line sensor during the event period.

Abstract: Techniques are disclosed for query processing system that can, when queried, generate a result related to one or more connectivity paths and/or one or more network security rules. Network security rules and connectivity paths may be stored in corresponding data structures (e.g., sets of attributes) that may be utilized with a number of set operations. The user may issue a query requesting the system to apply a rule to a path, a set of rules to a set of paths, to identify if one set of rule(s) are equivalent to another set of rule(s), and the like. Utilizing this query processing system can enable a user to identify effects of one or more network rules with respect to traffic being allowed or restricted along particular connectivity paths between components of the system.