Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: The present disclosure generally relates to methods and systems for generating a void profile for user void events. The method includes receiving by a processing element a plurality of outputs from a fluid level sensor corresponding to a plurality of levels of fluid flowing through a voiding device during a flow event; determining by the processing element a beginning and an end time of the fluid flow into the voiding device during the flow event; analyzing the plurality of outputs of the fluid level sensor over a time interval defined by the beginning and end time of the fluid flow to determine at least one of a fluid flow rate data and an accumulated volume data for the fluid flowing through the voiding device; and storing the fluid flow rate data and the accumulated flow volume data in a memory.

Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.

Abstract: Uroflowmeters and methods for processing data generated therefrom are disclosed. In one aspect, the uroflowmeter is a handheld device. The uroflowmeter includes a handle, a flow chamber coupled to the handle, and a sensor associated with the flow chamber that detects a parameter of urine received in the flow chamber. The uroflowmeter may include both reusable and disposable components. As a uroflowmeter it can identify and record data corresponding to the rate of flow over the measured duration of a void of urine, but may also timestamp the voiding act and communicate the data to an external data collection center for additional analysis and incorporation into a comprehensive voiding report or voiding diary.

Abstract: A system and method for transferring a part being machined by a machine from a first fixture to a second fixture so that an un-machined side of the part can be exposed for machining, where the first fixture is secured to a first actuator and the second fixture is secured to a second actuator. The method includes securing the part to the first fixture, operating the first actuator so that the part is able to be machined on sides of the part except a side of the part coupled to the first fixture, and machining the part while the part is secured to the first fixture. The method operates the first actuator and the second actuator so that the part secured to the first fixture is aligned with the second fixture, and secures the part to the second fixture and releases the part from the first fixture.

Abstract: The disclosure generally relates to ultra high molecular weight poly(ethylene) (“UHMWPE”) tubes with an average wall thickness of 0.2 mm or less; a tensile stress at break greater than 40 MPa; and a storage modulus of greater than 500 MPa at 23° C. The disclosure further relates to preparing and using such tubes and to constructions (e.g., catheter constructions) and components thereof including such tubes.

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: A payment processing method uses a credit push for completing a transaction at a terminal device. The process can include scanning an optical code at terminal device using a mobile device to determine creditor bank information. A debtor bank server receives the creditor bank information and provides a credit push request to a payment rail. The payment rail communicates a credit payment transaction request to a creditor bank sever. The creditor bank server identifies the terminal device and instructs completion of the transaction at the terminal device in an amount corresponding to the credit push request. The transaction is initiated at the terminal device. An authentication procedure for facilitating the transaction by communicating the creditor bank information is performed by the mobile device and not by the terminal device.

Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.

Abstract: A payment processing method uses a credit push for disbursing funds at ATM. The process can include scanning an optical code at an ATM using a mobile device to determine creditor bank information. A debtor bank server receives a funds disbursement request and provides a credit push request to a payment rail. The payment rail communicates a credit payment transaction request to a creditor bank sever. The creditor bank server identifies the ATM using an ATM identifier provided to the mobile device via the optical code. The ATM is instructed to disburse funds by the creditor bank server. The method includes using the mobile device, or other issuer domain, authentication procedures. The funds can be disbursed by the ATM without the ATM performing any authentication procedures.

Abstract: A linear luminaire includes a three-sided enclosure with a top that is at least translucent and a pair of depending sidewalls spaced apart by the top. The three-sided enclosure may be extruded from a plastic or, in some cases, co-extruded with two different materials so that the pair of sidewalls can be made of an opaque material. The three-sided enclosure may be open along a bottom aspect. An elongate rigid printed circuit board (PCB) carrying LED light engines is installed between the pair of sidewalls in slot structure defined on respective inner faces. The PCB may carry connecting structure staggered along the length of its underside. The PCB may also carry circuit components on its underside.

Abstract: According to various aspects, systems and methods are provided for automatically matching recruiters to job openings. The system may train one or more models that determine a measure of compatibility between a recruiter and a job opening. The system may train the model(s) using stored records of activity tracked by the system. The measure of compatibility may be used to determine whether a recruiter is likely to place a candidate for a job opening. Some embodiments provide a system that can collect objective data about recruiters and hiring parties, and use the objective data to train the model(s).

Abstract: Systems and methods are provided for delivering images to a patient before and/or during a medical procedure in which a patient is translated on a table relative to a gantry. In various example embodiments, images are projected to the patient while preserving the projected field size during table motion, thereby potentially reducing patient anxiety by providing a more immersive patient viewing experience. In some embodiments, the projected field size is maintained by a display system that is secured to the table such that both a projector and a projection screen are fixed relative to the table, and relative to the patient, during translation of the table. In some example embodiments, a reduction in patient anxiety may be achieved by projecting images as virtual images that are perceived by the patient as residing at a depth that lies beyond the confined spatial region in which the patient resides.

Abstract: A payment processing method uses a credit push for disbursing funds at ATM. The process can include scanning an optical code at an ATM using a mobile device to determine creditor bank information. A debtor bank server receives a funds disbursement request and provides a credit push request to a payment rail. The payment rail communicates a credit payment transaction request to a creditor bank sever. The creditor bank server identifies the ATM using an ATM identifier provided to the mobile device via the optical code. The ATM is instructed to disburse funds by the creditor bank server. The method includes using the mobile device, or other issuer domain, authentication procedures. The funds can be disbursed by the ATM without the ATM performing any authentication procedures.

Abstract: According to various aspects, systems and methods are provided for automatically matching recruiters to job openings. The system may train one or more models that determine a measure of compatibility between a recruiter and a job opening. The system may train the model(s) using stored records of activity tracked by the system. The measure of compatibility may be used to determine whether a recruiter is likely to place a candidate for a job opening. Some embodiments provide a system that can collect objective data about recruiters and hiring parties, and use the objective data to train the model(s).

Abstract: In various embodiments, an engine mount may comprise a mount base configured to physically engage at least a portion of an engine positioned adjacent thereto so as to secure the engine in a mounted position relative to the engine mount, the mount base comprising: a base component; an engine positioning element protruding from the base component and configured to restrict a range of motion of the engine in at least one direction; and at least one base orifice extending through a thickness of the base component and configured to receive a protruding portion of the engine within an internal volume of the base orifice; and an attachment hub comprising one or more attachment features configured to receive at least a portion of an external engine tool and engage the external engine tool such that at least a portion of the external engine tool is arranged adjacent the mount base.

Abstract: A one-piece shield for temporarily covering the upper inlet of a downspout. The shield includes a single sheet of resilient material, with a pair of tabs that cooperate with a slot in the sheet. The sheet is rolled up to create a tubular portion. One of the tabs is turned into the tubular portion to block the passage into the tubular portion, and the other tab cooperates with the slot to keep the device rolled up, so that the tubular portion blocks entry of debris into the downspout. The device is unrolled after use, and stored flat.

Abstract: A method for assisting transactions preferably includes a relayer wherein the relayer maintains an orderbook, and wherein the relayer is specified as the taker on all orders in the orderbook. The method incorporates matching buy and sell orders into a single, atomized batch order, price adjusting for spread, and passing the gain from the spread to the second order in the orderbook.

Abstract: The present disclosure provides communication systems and devices for use in noise environments, such as during magnetic resonance imaging (MRI). In some embodiments, a communication headrest is provided that consists of a headrest that supports a patients' head, an optional bone conduction microphone, and one or more vibration actuators. The headset makes contact with noise-isolating earplugs worn by the subject such that vibrations generated by the vibration actuators are transferred through the earplug, via acoustic conduction, to enable the patient to hear audio content while the earplugs provide passive noise protection by occluding the ear canal.

Abstract: Systems and methods are provided for delivering images to a patient before and/or during a medical procedure in which a patient is translated on a table relative to a gantry. In various example embodiments, images are projected to the patient while preserving the projected field size during table motion, thereby potentially reducing patient anxiety by providing a more immersive patient viewing experience. In some example embodiments, the projected field size is maintained by a display system that is secured to the table such that both a projector and a projection screen are fixed relative to the table, and relative to the patient, during translation of the table. In some example embodiments, a reduction in patient anxiety may be achieved by projecting images as virtual images that are perceived by the patient as residing at a depth that lies beyond the confined spatial region in which the patient resides.