Patents by Inventor Robert A Heald

Robert A Heald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N, N-disubstituted quino[4,3,2-kl]acridinium salts as therapeutic agents
    Patent number: 7115619
    Abstract: The present invention pertains to certain N8,N13-disubstituted quino[4,3,2-kl]acridinium salts of formula (Q?) which inhibit telomerase wherein: p is an integer from 0 to 4; q is an integer from 0 to 3; r is an integer from 0 to 4; each RA is —H or a ring substituent; each RB is —H or a ring substituent; each RC is —H or a ring substituent; RN8 is a nitrogen substituent; RN13 is a nitrogen substituent; and, Q is an anion. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative conditions, such as cancer.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: October 3, 2006
    Assignee: Cancer Research Technology Limited
    Inventors: Malcolm F. G. Stevens, Lloyd R Kelland, Robert A Heald