Patents by Inventor Robert A. Hodges

Robert A. Hodges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified proteins comprising controllable intervening protein sequences or their elements methods of producing same and methods for purification of a target protein comprised by a modified protein
    Patent number: 5834247
    Abstract: The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into or adjacent a target protein, the CIVPS being capable of excision from or cleavage of the modified protein under predetermined conditions in cis or in trans, i.e., increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation, treatment with chemical reagents or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity. The CIVPS may be used in a number of applications including purification of the target protein in a one-step protocol.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 10, 1998
    Assignee: New England Biolabs, Inc.
    Inventors: Donald G. Comb, Francine B. Perler, William E. Jack, Ming-Qun Xu, Robert A. Hodges, Christopher J. Noren, Shaorong S. C. Chong, Eric Adam, Maurice Southworth
  • Modification of protein by use of a controllable interveining protein sequence
    Patent number: 5496714
    Abstract: The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into a target protein, the CIVPS being capable of excision from the modified protein under predetermined conditions, i.e., increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity.
    Type: Grant
    Filed: December 9, 1992
    Date of Patent: March 5, 1996
    Assignee: New England Biolabs, Inc.
    Inventors: Donald G. Comb, Francine B. Perler, William E. Jack, Ming-Qun Xu, Robert A. Hodges
  • Malolactic gene
    Patent number: 4472502
    Abstract: DNA sequences which are capable of converting L-malate into L-lactate are incorporated into suitable vectors and used to transform both prokaryotic and eukaryotic hosts. The DNA sequences and vectors are particularly useful in conferring the ability to perform malolactic fermentation on wine producing yeasts.Saccharomyces cerevisiae 2514-10C/ySWl and E. coli RRI/ySWl were deposited at the A.T.C.C. on Aug. 16, 1982, and given accession Ser. Nos. 20651 and 39176, respectively.
    Type: Grant
    Filed: August 16, 1982
    Date of Patent: September 18, 1984
    Assignee: The Regents of the University of California
    Inventors: Sidney R. Snow, Ralph E. Kunkee, Robert A. Hodges, Steven A. Williams
  • Eyeglass frame
    Patent number: D304835
    Type: Grant
    Filed: April 20, 1987
    Date of Patent: November 28, 1989
    Inventor: Robert A. Hodges