Abstract: The platforms, systems and methods provided herein may provide a data-driven workflow platform. The method comprises: mapping selected data objects to a data storage model of the data-driven workflow platform, where the selected data objects are stored in a data cloud configuration that is operatively coupled to the data-driven workflow platform; and displaying, on a graphical user interface (GUI), a flow for building a cloud application utilizing or managing the selected data objects. The interactive flow comprises at least one graphical element corresponding to a rule for automating an action triggered by a triggering event of the selected data objects.

Abstract: The invention relates to a hair styling device, and in particular to a hair straightener. The hair styling device (10; 210) has a first arm (12; 212) and a second arm (14; 214), the first and second arms being moveable relative to one another between a closed or operative condition and an open or inoperative condition. The first member (12; 212) has a first heating panel (16; 116; 216) and the second member (14; 214) has a second heating panel (18; 118; 218). The heating panels (16, 18; 116, 118; 216, 218) are corrugated to increase the length of the path the hair must take between the heating panels. The first and second heating panels are spaced apart in the operative condition so as not to press or clamp the hair therebetween.

Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.

Abstract: A downhole tool configured for inclusion in a drill string, typically as part of a bottom hole assembly. The downhole tool configured to improve passage of the drill string through a borehole. Additionally, the downhole tool is suitable for use in a method for improving passage of a drill string through a borehole.

Abstract: This disclosure provides methods for using a particular class of apelin receptor modulators to reduce blood-brain barrier (BBB) permeability in a subject in need thereof, and in particular methods of treatment for a variety of disorders, conditions, and diseases associated with and related to increased BBB permeability. This disclosure also provides methods for using a particular class of apelin receptor modulators to treat a neurodegenerative disease, delirium, and/or dementia in a subject in need thereof. This disclosure also provides methods for using a particular class of apelin receptor modulators to reduce neuroinflammation in a subject in need thereof. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.

Abstract: Methods, computing systems, and computer-readable media for dynamically adjusting drilling parameters during a drilling operation. The approach involves receiving, in real time, drilling parameter measurements and response measurements during a drilling operation. If the response measurements are below the lower limit of a window or trending downwards, the approach determines a new drilling parameter value that will increase the response measurement. The approach dynamically adjusts the drilling parameter value above the sectional limit, while still respecting hard limits. When the measured value improves, the approach returns the limit for the drilling parameter to the sectional limit.

Abstract: The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.

Abstract: The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.

Abstract: A filter element (2) is disclosed which comprises a filtration media (4) and an end fitting (6) through which a sealing connection is made between the filter element and a housing (100) so that, when the sealing connection is made, the end fitting defines in part a flow path for fluid between the housing and the filter element. The end fitting includes an annular seal (36?) made from a compressible material which extends around the periphery of the filter element, and a support (30, 31, 32, 34) for the annular seal which can be expanded outwardly to cause the transverse dimension of the seal to increase so that the seal is urged into contact with an inner wall of a housing (100) in which the filter element is located.

Abstract: The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.

Abstract: A coupler for coupling an implement having first and second spaced apart parallel pins, to the arm of a vehicle. The coupler has a body for attaching to the vehicle arm, a first fixed jaw, a movable second jaw facing away from the first jaw, and an actuator to selectively move the second jaw towards and away from the first jaw. The first jaw includes a lip forward of the seat for the first pin. A first locking member is pivotable between a locking position, in which a portion of the locking member protrudes into the opening of the first jaw, and an unlocked position. A second locking member is pivotable between a locking position in which a portion of the second locking member constricts the opening of the second jaw, and an unlocked position. Movement of the second jaw causes movement of the first locking member.

Abstract: A technique includes receiving data representing a measurement acquired by a tool motion sensor of a downhole sonic measurement tool; and receiving data representing a measurement acquired by a pressure sensor of the sonic measurement tool. The technique includes modifying the measurement acquired by the pressure sensor based at least in part on the measurement acquired by the tool motion sensor to attenuate tool borne noise.

Abstract: The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.

Abstract: This disclosure describes systems, methods, and devices related to label based isochronous connection update. A central Bluetooth low energy (BLE) device may send a plurality of labels to a peripheral BLE device during a setup of a BLE communication to notify the peripheral BLE device of one or more labels to be used during the BLE communication. The central BLE device may determine a channel variation between the central BLE device and the peripheral BLE device. The central BLE device may send a first label to the peripheral BLE device to indicate an isochronous (ISO) parameter update that will occur at a first time offset based on the channel variation. The central BLE device may implement the isochronous parameter update at the first time offset based on the channel variation.

Abstract: Methods, apparatus, systems and articles of manufacture to improve Bluetooth low energy streaming connection efficiency are disclosed herein. An example method includes accessing a request received at a first device from a second device, the request requesting set up of an isochronous link between the first device and the second device, the request including a configuration identifier. Whether the configuration identifier identifies a configuration stored at the first device is determined. In response to determining that the configuration identifier identifies the configuration stored at the first device, the isochronous link using the stored configuration.

Abstract: The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.

Abstract: A shoe-opening spring includes a base with a medial edge and a lateral edge, a medial spring protruding upwardly from the medial edge of the base, and a lateral edge protruding upwardly from the lateral edge of the base. When the shoe-opening spring is present within a shoe and in a relaxed arrangement, the medial spring and the lateral spring may respectively exert medially and laterally outward forces against respective medial and lateral sides of the shoe. When the medial and lateral sides of the upper of the shoe are pulled together, for example, with a closure of the shoe, the shoe-opening spring may be placed in a tensed arrangement, in which state the shoe-opening spring may remain until the closure is released.

Abstract: Systems and methods for recovering unmanned aircraft and controlling post-recovery motion of the aircraft are disclosed herein. An aircraft recovery system for handling an unmanned aircraft in accordance with one embodiment of the disclosure includes a base portion and an elongated aircraft capture member having a first end movably coupled to the base portion and a second, free end opposite the first end. The aircraft capture member includes a first portion and a second portion at a distal end of the first portion and positioned to intercept an unmanned aircraft in flight. The first and/or second portions are generally flexible. The system further includes an energy capture and dissipation assembly operably coupled to the aircraft capture member and positioned to receive at least a portion of the landing forces from the aircraft.

Abstract: Embodiments of the present disclosure include methods, devices and systems for Bluetooth low energy discovery in wireless application service platforms. One example embodiment relates to transmitting, by a first terminal including a radio, a request message for seeking service, receiving, by a peer terminal, the request message for seeking service, transmitting to the first terminal, by the peer terminal, a response frame advertising service including service provider information.

Abstract: The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.