Patents by Inventor Robert A. Izydore

Robert A. Izydore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5192761
    Abstract: The invention provides pharmaceutical compositions comprising hypolipidemically active derivatives of 1,2,4-triazolidine-3,5-diones, 1,3,5-triazabicyclo[3.1.0]hexane-2,4-diones, and 1,3,5-triazine-2,4(1H,3H)-diones in a pharmaceutically acceptable carrier for treating hyperlipidemia in mammals, particularly humans.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: March 9, 1993
    Assignees: North Carolina Central Univ., University of North at Chapel Hill
    Inventors: Robert A. Izydore, Iris H. Hall
  • Patent number: 5034528
    Abstract: The invention provides pharmaceutical compositions comprising hypolipidemically active derivatives of 1,2,4-triazolidine-3,5-diones, 1,3,5-triazabicyclo[3.1.0]hexane-2,4-diones, and 1,3,5-triazine-2,4(1H,3H)-diones in a pharmaceutically acceptable carrier for treating hyperlipidemia in mammals, particularly humans.
    Type: Grant
    Filed: July 27, 1988
    Date of Patent: July 23, 1991
    Assignees: North Carolina Central University, The University of North Carolina at Chapel Hill
    Inventors: Robert A. Izydore, Iris H. Hall
  • Patent number: 4999366
    Abstract: A method of controlling hyperlipidemia in mammals which comprises adminstering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different provided both are not hydrogen when R.sup.3 is an alkenyl or cycloalkenyl group, are selected from the group consisting of hydrogen; alkyl of 1 to 18 carbons; substituted alkyl of 1 to 18 carbons; cycloalkyl of 4 to 10 ring carbon atoms; substituted cycloalky of 4 to 10 ring carbon stoms; alkoxy of 1 to 8 carbon atoms; amido; carbamoyl; acyloxy; alkoxycarbonyl; halogen, aryl and substituted aryl, or together R.sup.1 and R.sup.2 from a C.sub.3 to C.sub.7 alkylene group; andR.sup.3 is hydrogen; lower alkyl; substituted lower alkyl; cycloalkyl; substituted cyloalkyl; aryl; substituted aryl; a group --COR.sup.4 were R.sup.
    Type: Grant
    Filed: March 12, 1990
    Date of Patent: March 12, 1991
    Assignees: The North Carolina Central Univ., The Univ. of North Carolina at Chapel Hill
    Inventors: Robert A. Izydore, Iris H. Hall
  • Patent number: 4946963
    Abstract: An isoxazolidin-3,5-dione for the control of hyperlipidemia in mammals having the following structural formula: ##STR1## wherein R.sup.1 and R.sup.2 are each an alkyl of 1 to 4 carbons; R.sup.3 is an alkoxybenzoyl group containing from 1 to 3 alkoxy groups wherein the alkoxy groups have from 1 to 4 carbon atoms, an alkoxybenzoyl group wherein the alkyl group had from 1 to 4 carbons, a halobenzoyl group, or a group ##STR2## where together R.sup.10 and R.sup.11 form a C.sub.3 to C.sub.7 alkylene group, and R.sup.12 and R.sup.13 are each alkyl from 1 to 4 carbon atoms.
    Type: Grant
    Filed: October 31, 1988
    Date of Patent: August 7, 1990
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Robert A. Izydore, Iris H. Hall
  • Patent number: 4866058
    Abstract: The present invention is directed to a method of controlling hyperlipidemia in mammals which comprises administering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1 to C.sub.18 alkyl or substituted alkyl, a C.sub.2 to C.sub.18 alkenyl or substituted alkenyl, a C.sub.2 to C.sub.18 alkynyl or substituted alkynyl, a C.sub.4 to C.sub.10 cycloalkyl or substituted cycloalkyl, a C.sub.4 to C.sub.10 cycloalkenyl or substituted cycloalkenyl, phenyl, a substituted phenyl, cyano, phenalkyl, --CO--R.sup.9 or --Y--CO--R.sup.9 ;R.sup.2 is ##STR2## R.sup.3 and R.sup.4 can be the same or different and are each the same as R.sup.1 ;R.sup.5, R.sup.6 and R.sup.7 can be the same or different and are each hydrogen, a C.sub.1 to C.sub.18 alkyl or substituted alkyl, a C.sub.2 to C.sub.18 alkenyl or substituted alkenyl, a C.sub.1 to C.sub.18 alkynyl or substituted alkynyl, a C.sub.4 to C.sub.
    Type: Grant
    Filed: July 27, 1988
    Date of Patent: September 12, 1989
    Inventors: Robert A. Izydore, Iris H. Hall