Patents by Inventor Robert A. Lazzarini

Robert A. Lazzarini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY ENGINEERED ANIMALS CONTAINING NULL MUTATIONS IN THE NEUROFILAMENT GENES
    Publication number: 20020157118
    Abstract: The present invention provides for genetically engineered non-human animals, including but not limited to mice, which lack one or more endogenous neurofilament gene. Human neurofilament genes may be introduced into such genetically non-human animals (referred to hereafter as “knockout animals”) to produce improved models of the physiology of human neurofilament proteins which may be used to study human neurofilament-associated neurodegenerative conditions.
    Type: Application
    Filed: June 22, 1999
    Publication date: October 24, 2002
    Inventors: ROBERT A. LAZZARINI, GREGORY ELDER
  • Transgenic animal models for neurodegenerative disease
    Patent number: 5602299
    Abstract: The design, construction, and use of transgenic animals which exhibit features, including neurofibrillary tangles and aluminum sensitivity, is described. The founder transgenic animals of the invention are produced by methods well known in the art, and utilize DNA sequences designed to express all or any part of the human neurofilament subunit genes, NF-L, NF-M, NF-H, in a neural-enriched manner.
    Type: Grant
    Filed: September 23, 1992
    Date of Patent: February 11, 1997
    Assignee: Mount Sinai School of Medicine of the City University of New York
    Inventor: Robert A. Lazzarini