Abstract: Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: Apparatuses and methods are described for controlling the thickness of glass during glass sheet production. The apparatuses and methods employ a laser beam to heat a particular portion of the molten glass. In some examples, a laser beam control system controls the laser beam to generate a more consistent glass thickness across the glass sheet. In some examples, the laser beam control system multiplexes the laser beam to heat various portions of the glass, for example, simultaneously.

Abstract: A method for plugging a subset of cells of a honeycomb structure that includes: covering a first end face of the honeycomb structure with a mask that comprises a body and a plurality of openings, wherein the plurality of openings of the mask is coincident with a plurality of cells of the honeycomb structure; providing a plug of material upon a film material; applying a force to the film material to push the plug of material through the plurality of openings of the mask and into the plurality of cells of the honeycomb structure; and measuring a pressure within the plurality of cells during the applying step, wherein the applying step further comprises adjusting the force applied to the film material based at least in part on the pressure within the plurality of cells to push the plug of material to a predetermined depth within the plurality of cells.

Abstract: A floating shelf, comprising: (1) a shelf; and (2) a floating shelf bracket that is configured to support the shelf and that comprises a support connector and two or more shelf supports that are attached to one another by the support connector. The support connector and the two or more shelf supports may be attached to one another so that the floating shelf bracket is a unitary, single-piece bracket. In various embodiments, the top surface of each of the two or more shelf supports is positioned below a top of the support connector so that when a bottom surface of the shelf is positioned on the top surface of each of the two or more shelf supports, the top of the support connector is substantially concealed behind the shelf.

Abstract: The present disclosure provides a shelf and bracket system that comprises a shelf and a bracket assembly. In various embodiments, the bracket assembly comprises a main bracket bar, a plurality of support arms, and hardware for attaching each of the plurality of support arms to the main bracket bar. In addition, in various embodiments, each support arm is disposed adjacent a respective end of the main bracket bar and the respective first hardware for the support arm is configured such that, when disengaged, the support arm is configured to rotate between a shelf support position and a folded storage position so that when each of the plurality of support arms are in the folded storage position, the bracket assembly is substantially flat.

Abstract: An electronic door lock includes an electromechanical locking mechanism, computer hardware configured for selectively moving the electromechanical locking mechanism between a locked configuration and an unlocked configuration, and one or more networking components that are configured for facilitating communication between the computer hardware and one or more computer networks that are external to the electronic door lock. The electronic door lock maybe configured for receiving an access code from a user, analyzing the access code to determine whether the access code is a first particular code or a second particular code, in response to determining that the access code is the first particular code, causing the electromechanical locking mechanism to disengage a lock component configured to prevent a door from opening, and in response to determining that the access code is the second particular code, initiating a transmission of an emergency signal via the one or more networking components.

Abstract: An electronic door lock includes a housing having a keypad window, a keypad inserted into the keypad window and having a plurality of depressible buttons, and a bezel surrounding the keypad and having a spar, the spar lying between the buttons and providing support to the plurality of depressible buttons in a direction substantially perpendicular to a press direction. The electronic door lock may also have a circuit board which detects button depressions. The housing may be constructed with a single cut designed to enclose multiple buttons, reducing manufacturing costs. The keypad may have a flexible support webbing with chambers corresponding to the buttons. Certain chambers may be connected, allowing a single LED to illuminate multiple buttons, further reducing manufacturing cost.

Abstract: A method for inspecting a transparent workpiece comprises: directing light from an illumination source onto a plurality of defects formed in the transparent workpiece, wherein the plurality of defects extends in a defect direction, wherein the transparent workpiece comprises a first surface and a second surface; detecting a scattering image signal from light scattered by the plurality of defects using an imaging system, wherein an imaging axis of the imaging system extends at a non-zero imaging angle relative to the defect direction, wherein entireties of at least a subset of the plurality of defects are within a depth of field of the imaging system; and generating a three-dimensional image of at least one of the plurality of defects based on the scattering signal.

Abstract: Defect detection systems include at least one nozzle for delivering a CO2 particulate fluid to an inlet end of a plugged honeycomb body. Defects in the honeycomb, if any, are determined by monitoring CO2 particulate flow at the outlet end of the honeycomb body. Methods for detecting defects in plugged honeycomb bodies are also disclosed.

Abstract: A floating shelf includes a plank shelf, and a floating shelf bracket, configured to support the plank shelf, including a support connector and two or more shelf supports attached to one another by the support connector. The support connector and the two or more shelf supports may be permanently attached to one another so that the floating shelf bracket is a unitary, single-piece bracket. The support connector and the two or more shelf supports may be removably attached to one another.

Abstract: The present disclosure provides a shelf and bracket system that comprises a shelf and a bracket assembly. In various embodiments, the bracket assembly comprises a main bracket bar, a plurality of support arms, and hardware for attaching each of the plurality of support arms to the main bracket bar. In addition, in various embodiments, each support arm is disposed adjacent a respective end of the main bracket bar and the respective first hardware for the support arm is configured such that, when disengaged, the support arm is configured to rotate between a shelf support position and a folded storage position so that when each of the plurality of support arms are in the folded storage position, the bracket assembly is substantially flat.

Abstract: Methods of manufacturing a glass ribbon include moving a ribbon of glass-forming material along a travel path in a travel direction. Methods include sensing a thickness of the ribbon of glass-forming material at a plurality of locations of the ribbon of glass-forming material. Methods include identifying a location of the plurality of locations in which a corresponding thickness at the location exceeds a target thickness. Methods include correlating a rate of thickness change and a thickness difference between the corresponding thickness and the target thickness to a laser power. Methods include directing a laser beam at the laser power toward the ribbon of glass-forming material to decrease a viscosity at the location and attain the target thickness at the location.

Abstract: A floating shelf includes a plank shelf, and a floating shelf bracket, configured to support the plank shelf, including a support connector and two or more shelf supports attached to one another by the support connector. The support connector and the two or more shelf supports may be permanently attached to one another so that the floating shelf bracket is a unitary, single-piece bracket. The support connector and the two or more shelf supports may be removably attached to one another.

Abstract: A catheter device and method for treating an artery with thrombus, the catheter comprising an inflatable member. A carrier catheter has a proximal end and a distal end adapted to be inserted percutaneously into an artery, the carrier catheter having a tubular body adjacent to a rear end of the inflatable member. An inflating tube passes through the tubular body and having an open front end in fluid communication with the inflatable member to inflate same. An infusion tube is adapted to infuse pharmacologic agents, the infusion tube passing through the tubular body and having an open front end extending beyond the inflatable member. An aspiration tube is adapted to aspire the thrombus, the aspiration tube passing through the tubular body and having an open front end between the carrier catheter and the inflatable member.

Abstract: A floating shelf includes a plank shelf, and a floating shelf bracket, configured to support the plank shelf, including a connecting bar and two or more bracket arms attached to one another by the connecting bar. The connecting bar and the two or more bracket arms may be permanently attached to one another so that the floating shelf bracket is a unitary, single-piece bracket. The connecting bar and the two or more bracket arms may be removably attached to one another.

Abstract: Defect detection systems include at least one nozzle for delivering a CO2 particulate fluid to an inlet end of a plugged honeycomb body. Defects in the honeycomb, if any, are determined by monitoring CO2 particulate flow at the outlet end of the honeycomb body. Methods for detecting defects in plugged honeycomb bodies are also disclosed.

Abstract: A method for plugging a subset of cells of a honeycomb structure that includes: covering a first end face of the honeycomb structure with a mask that comprises a body and a plurality of openings, wherein the plurality of openings of the mask is coincident with a plurality of cells of the honeycomb structure; providing a plug of material upon a film material; applying a force to the film material to push the plug of material through the plurality of openings of the mask and into the plurality of cells of the honeycomb structure; and measuring a pressure within the plurality of cells during the applying step, wherein the applying step further comprises adjusting the force applied to the film material based at least in part on the pressure within the plurality of cells to push the plug of material to a predetermined depth within the plurality of cells.

Abstract: A method and apparatus to protect the coded signals sent over physical twisted-pair wiring or between two (2) or more LANs connected by a Wide Area Network (WAN), from unauthorized electronic circuit/wiring monitoring. This is accomplished by varying the assignments of the standard Registered Jack communication pins, varying the transmission speed, inserting meaningless or unrelated data, encrypting data before it is sent or changing network protocol(s) on behalf of the communications adapter/controller of each computer to which it is attached on those LANs.

Abstract: A method of inspecting defects on a transparent substrate may include: selecting a gradient of an illumination optical system so that light incident on the transparent substrate has a first angle; selecting a gradient of a detection optical system so that an optical axis of the detection optical system located over the transparent substrate has a second angle, which is equal to or less than the first angle; adjusting a position of at least one of the illumination optical system, the transparent substrate, and the detection optical system so that a field-of-view of the detection optical system covers a first region where the light meets a first surface of the transparent substrate and does not cover a second region where light meets a second surface of the transparent substrate, the second surface being opposite to the first surface; illuminating the transparent substrate; and detecting light scattered from the transparent substrate.