Abstract: The present disclosure relates to novel peptide antagonists that inhibit binding of melanocyte stimulating hormone to the melanocortin 1 receptor. The peptide antagonists of the disclosure are useful in cosmetic compositions that prevent or reduce the appearance of skin discoloration caused by pigmentation. The disclosure further relates to cosmetic compositions comprising a peptide antagonist of the disclosure, and methods for their use for preventing or reducing the appearance of skin discoloration in a subject in need thereof.

Abstract: The present disclosure relates to novel peptide antagonists that inhibit binding of melanocyte stimulating hormone to the melanocortin 1 receptor. The peptide antagonists of the disclosure are useful in cosmetic compositions that prevent or reduce the appearance of skin discoloration caused by pigmentation. The disclosure further relates to cosmetic compositions comprising a peptide antagonist of the disclosure, and methods for their use for preventing or reducing the appearance of skin discoloration in a subject in need thereof.

Abstract: The present invention relates to novel peptide antagonists that inhibit binding of acetylcholine to the active site of the muscle-type nicotinic acetylcholine receptor. The peptide antagonists of the invention are useful in cosmetic compositions that prevent or improve the appearance of skin wrinkles and related skin conditions. The invention further relates to cosmetic and pharmaceutical compositions comprising a peptide antagonist of the invention, and methods for their use.

Abstract: The present disclosure relates to novel peptide antagonists that inhibit binding of melanocyte stimulating hormone to the melanocortin 1 receptor. The peptide antagonists of the disclosure are useful in cosmetic compositions that prevent or reduce the appearance of skin discoloration caused by pigmentation. The disclosure further relates to cosmetic compositions comprising a peptide antagonist of the disclosure, and methods for their use for preventing or reducing the appearance of skin discoloration in a subject in need thereof.

Abstract: The present invention relates to compositions comprising and methods for use of formulations for the delivery of cosmetic agents, including anionic polymers such as hyaluronic acid and peptides with cosmetic activity. They are useful in, e.g., cosmetics and pharmaceuticals that prevent or improve the appearance of undesirable skin features including wrinkles or enhancing lip fullness.

Abstract: The present invention relates to novel peptide antagonists that inhibit binding of acetylcholine to the active site of the muscle-type nicotinic acetylcholine receptor. The peptide antagonists of the invention are useful in cosmetic compositions that prevent or improve the appearance of skin wrinkles and related skin conditions. The invention further relates to cosmetic and pharmaceutical compositions comprising a peptide antagonist of the invention, and methods for their use.

Abstract: The present invention relates to compositions comprising and methods for use of novel synthetic peptide antagonists. Antagonists of the invention inhibit the binding of acetylcholine to the muscle-type nicotinic acetylcholine receptor. They are useful in, e.g., cosmetics and pharmaceuticals that prevent or improve the appearance of undesirable skin features including wrinkles.

Abstract: The present invention relates to compositions comprising and methods for use of formulations for the delivery of cosmetic agents, including anionic polymers such as hyaluronic acid and peptides with cosmetic activity. They are useful in, e.g., cosmetics and pharmaceuticals that prevent or improve the appearance of undesirable skin features including wrinkles.

Abstract: The present invention relates to novel peptide antagonists that inhibit binding of acetylcholine to the active site of the muscle-type nicotinic acetylcholine receptor. The peptide antagonists of the invention are useful in cosmetic compositions that prevent or improve the appearance of skin wrinkles and related skin conditions. The invention further relates to cosmetic and pharmaceutical compositions comprising a peptide antagonist of the invention, and methods for their use.

Abstract: The present invention relates to compositions comprising and methods for use of novel synthetic peptide antagonists. Antagonists of the invention inhibit the binding of acetylcholine to the muscle-type nicotinic acetylcholine receptor. They are useful in, e.g., cosmetics and pharmaceuticals that prevent or improve the appearance of undesirable skin features including wrinkles.

Abstract: The present invention relates to novel peptide antagonists that inhibit binding of acetylcholine to the active site of the muscle-type nicotinic acetylcholine receptor. The peptide antagonists of the invention are useful in cosmetic compositions that prevent or improve the appearance of skin wrinkles and related skin conditions. The invention further relates to cosmetic and pharmaceutical compositions comprising a peptide antagonist of the invention, and methods for their use.

Abstract: The present invention relates to novel peptide antagonists that inhibit binding of acetylcholine to the active site of the muscle-type nicotinic acetylcholine receptor. The peptide antagonists of the invention are useful in cosmetic compositions that prevent or improve the appearance of skin wrinkles and related skin conditions. The invention further relates to cosmetic and pharmaceutical compositions comprising a peptide antagonist of the invention, and methods for their use.

Abstract: A fuel cell plate is provided that includes a flow field having a plurality of channels each with an inlet end, and a header in fluid communication with the inlet ends. The header has at least one restricted flow region in which fluid flow is restricted to the inlet ends of a set of channels of the flow field and at least some of the plurality of channels include a pressure drop feature that is configured to increase fluid flow to the set of channels.

Abstract: A fuel cell installation includes a support structure and a cell stack assembly that is removably insertable into the support structure from an uninstalled position to an installed position during an installation procedure. The cell stack assembly includes a fitting. An interfacing structure is mounted on one of the support structure in the cell stack assembly. The interfacing structure carries a connector that is configured to receive the fitting in interconnected relationship. At least one of the fitting and the connector floats in a plane relative to the support structure during the installation procedure. In operation, the fitting engages the connector when the cell stack assembly is inserted into the support structure. The fitting is repositioned relative to the connector to ensure that the fitting and connector are aligned with one another and connected upon installation. Related methods are disclosed.

Abstract: Fuel cell systems (10) and related methods for limiting fuel cell slippage are provided. A stacked plurality of adjacent fuel cells (14) collectively forming a fuel cell stack (12). The fuel cells each include a pair of first and second plates (30, 30?, 30?; 32, 32?, 32?) at respective opposite ends thereof. A first fuel cell has a first plate (30, 30?, 30?) in engagement with a second plate (32, 32?, 32?) of a second fuel cell adjacent to the first fuel cell. A slip mitigation arrangement (50, 50?, 50?) between at least one of the pairs of the first and second fuel cells comprises first and second seats (62, 62?, 62?; 64, 64?, 64?) recessed in the engagement surfaces of the first and second conductive plates respectively, and a key member (60, 60?, 60?) having opposite ends seated in the first and the second recessed seats such that relative movement between the first and the second fuel cells is limited.

Abstract: An electrical power outlet having an outlet box and an electrical connector insert attached to the outlet box. The electrical connector insert has a frame and a powerpole connector assembly attached to the frame. The powerpole connector assembly has a plurality of powerpole connectors. The electrical power outlet includes a face plate that is attached to the frame of the electrical connector insert. The faceplate has an opening through which the powerpole connectors protrude. In one embodiment, the plurality of powerpole connectors has four powerpole connectors arranged in two columns, wherein each column has two powerpole connectors. The opening in the face plate is substantially rectangular in shape. In a preferred embodiment, the face plate is configured as a Decora® style face plate.

Abstract: A fuel cell plate is provided that includes a flow field having a plurality of channels each with an inlet end, and a header in fluid communication with the inlet ends. The header has at least one restricted flow region in which fluid flow is restricted to the inlet ends of a set of channels of the flow field and at least some of the plurality of channels include a pressure drop feature that is configured to increase fluid flow to the set of channels.

Abstract: A fuel cell installation includes a support structure and a cell stack assembly that is removably insertable into the support structure from an uninstalled position to an installed position during an installation procedure. The cell stack assembly includes a fitting. An interfacing structure is mounted on one of the support structure in the cell stack assembly. The interfacing structure carries a connector that is configured to receive the fitting in interconnected relationship. At least one of the fitting and the connector floats in a plane relative to the support structure during the installation procedure. In operation, the fitting engages the connector when the cell stack assembly is inserted into the support structure. The fitting is repositioned relative to the connector to ensure that the fitting and connector are aligned with one another and connected upon installation.

Abstract: A utility receptacle apparatus for use with an article of furniture having a work surface and an opening in the work surface. The utility receptacle apparatus has a grommet member having a top side, a bottom side, a peripheral portion and an opening. The bottom side has a structure that fits into an opening in the work surface. The peripheral portion contacts the work surface when the structure is disposed within the opening in the work surface. The utility receptacle apparatus includes a receptacle base member that is configured to be attached to the underside of a work surface of the article of furniture. A utility receptacle is located on the receptacle base member at a predetermined location so that the utility receptacle is accessible through the openings in the work surface and grommet member when the receptacle base member is attached to the underside of the work surface.

Abstract: An electrical power outlet having an outlet box and an electrical connector insert attached to the outlet box. The electrical connector insert has a frame and a powerpole connector assembly attached to the frame. The powerpole connector assembly has a plurality of powerpole connectors. The electrical power outlet includes a face plate that is attached to the frame of the electrical connector insert. The faceplate has an opening through which the powerpole connectors protrude. In one embodiment, the plurality of powerpole connectors has four powerpole connectors arranged in two columns, wherein each column has two powerpole connectors. The opening in the face plate is substantially rectangular in shape. In a preferred embodiment, the face plate is configured as a Decora® style face plate.