Abstract: The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the “GD domain,” which is essential both to Bak's interaction with Bcl-xL, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.

Abstract: A modular display system having individual stackable electronic display panels of convenient and portable size and mounting structures for the support thereof where the stackable electronic display panels mutually juxtapose, mate, and robustly and mutually and adjustably secure together by the use of connector plates at the top of stackable electronic display panels interfacing with interlocking lower connector assemblies and lower connector plate receptors at the bottom of an overhead vertically situated stackable electronic display panel and by interfacing of latches and cams of latch keeper assemblies at the sides of horizontally situated stackable electronic display panels to form a large electronic sign display. Spring-loaded slide pin assemblies foster rapid and secure connection between vertically situated stackable electronic display panels. Adjustment features are also incorporated to align each stackable electronic display panel.

Abstract: Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.

Abstract: A programmable element includes a diode and a programmable structure formed in a polysilicon layer isolated from a semiconductor substrate by a dielectric layer. The diode includes a first region and a second region of opposite conductivity types. The programmable structure includes a third region and a fourth region of opposite conductivity types. The first region of the diode and the third region of the programmable structure are electrically connected. In operation, the programmable structure is programmed to a low impedance state when a voltage exceeding a first breakdown voltage of the programmable structure is applied to reverse bias the programmable structure. The programmable element can be used to form a programmable array having very low parasitic capacitance, enabling the realization of a large and ultra fast programmable logic array.

Abstract: The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of said antibodies, humanized and resurfaced versions of said antibodies, functional equivalents and improved versions of said antibodies, immunoconjugates and compositions comprising said antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding the antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing the antibodies.

Abstract: The invention relates to conjugates of anti-integrin specific antibodies with cytotoxic compounds, the synthesis, selection, and use of such conjugates for use in cancer therapy or other diseases mediated by cell proliferation, cell migration, or inflammation and which pathology involves angiogenesis or neovascularization of new tissue. In addition the invention relates to combination therapy of such diseases wherein the treatment comprises use of said conjugates in combination with one or more other treatment modalities including but not limited to: chemotherapy, surgery or radiation therapy. The preferred conjugates contain maytansinoid compounds linked to the antibody by a disulfide linkage, and preferred chemotherapeutic agents are doxorubicin, a taxane, a camptothecin, a podophyllotoxin, a nucleoside analog, or a pyrimidine analog.

Abstract: A programmable element includes a diode and a programmable structure formed in a polysilicon layer isolated from a semiconductor substrate by a dielectric layer. The diode includes a first region and a second region of opposite conductivity types. The programmable structure includes a third region and a fourth region of opposite conductivity types. The first region of the diode and the third region of the programmable structure are electrically connected. In operation, the programmable structure is programmed to a low impedance state when a voltage exceeding a first breakdown voltage of the programmable structure is applied to reverse bias the programmable structure. The programmable element can be used to form a programmable array having very low parasitic capacitance, enabling the realization of a large and ultra fast programmable logic array.

Abstract: A method for producing a surface mounting optoelectronic component comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, whereby the optical device comes into contact with the casting compound.

Abstract: A thruster system is provided for a vehicle that can be used to reduce the roll propensity of a motor vehicle. The system utilizes a control system and multiple sets of thrusters which are strategically placed upon the vehicle. The control system is provided for detecting a potential roll condition and activates selected ones of the thrusters to produce a necessary thrust force for counteracting roll forces. The thrusters are connected to an on-board pressurized gas source that generates the anti-roll thrust force.

Abstract: A method for producing a surface mounting optoelectronic component comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, whereby the optical device comes into contact with the casting compound.

Abstract: The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

Abstract: The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of said antibodies, humanized and resurfaced versions of said antibodies, functional equivalents and improved versions of said antibodies, immunoconjugates and compositions comprising said antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding the antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing the antibodies.

Abstract: An electronic display module having a four-point latching system for incorporation into an electronic sign and process where more than one latch mechanism can be actuated simultaneously to deploy to engage the mounting panel assembly of an electronic sign. Gear operated actuating arms incorporated in an overcenter arrangement position latch in opposing latch mechanisms to position latch arms outwardly in a linear direction over a mounting panel assembly followed by pivotal latch positioning to rotationally engage the latch arms against the mounting panel assembly to secure the electronic display module to the mounting panel assembly.

Abstract: A unitary, one-piece anchor for connecting a roof truss or other building structural member to a cementitious wall to resist uplift and lateral forces.

Abstract: A method for producing a surface mounting optoelectronic component comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, whereby the optical device comes into contact with the casting compound.

Abstract: This invention relates to a method and apparatus for controlling the air-fuel ratio demanded by a fuel controller in order to maintain optimum performance of a catalytic converter. The invention provides a controller for requesting an air fuel ratio according to a switching value derived from an estimated oxygen storage value of a catalyst, in which the controller is arranged to perform the following steps a) request a maximum ratio of air to fuel when the switching value is less than a first threshold; b) gradually decrease the requested air to fuel ratio from said maximum ratio; c) request a minimum ratio of air to fuel when the switching value is greater than a second threshold; and d) gradually increase the requested air to fuel ratio from said minimum ratio.

Abstract: A method for producing a surface mounting optoelectronic component having comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, so whereby the optical device comes into contact with the casting compound.

Abstract: This invention relates to a method and apparatus for controlling the air-fuel ratio demanded by a fuel controller in order to maintain optimum performance of a catalytic converter.

Abstract: A self-warming battery for use in tactical electronics systems, having a housing containing one or more commercially available alkaline manganese dioxide battery cells, a temperature sensor disposed adjacent to the battery cells for monitoring the temperature thereof, load resistors disposed adjacent to the battery cells for cell warming, and a battery self-warming circuit disposed in the housing. The battery self-warming circuit is coupled to the battery cells and the temperature sensor, and selectively causes current flow through the battery cells in an initializing mode when the temperature sensor detects that the battery cells are below a predetermined temperature.