Abstract: A printing system includes: a plurality of unitary objects each having a unique identification code, a plurality of fixtures arranged on a base, and a printer controller. Each unitary object includes a uniquely-shaped three-dimensional body fixed to a plate by a connection mechanism. Each fixture includes: a fixture block defining a printing opening; and a plate guide defined in the fixture block and configured to receive the plate. A target region of the three-dimensional body is aligned within the printing opening of the fixture block when the plate is fixed within the plate guide. The printer controller is configured to: detect the unique identification code of each unitary object; and control an ink dispenser to print a unique topographical design on each aligned target region of each three-dimensional body, the unique topographical design being associated with the detected unique identification code.

Abstract: A cantilever assembly includes a cantilever arm having longitudinal fastening channels and slots in communication with the fastening channels. The assembly also includes an attachment bracket featuring a first leg portion and a second leg portion defining a seat there between with the leg portions featuring apertures. Bolts having threaded shafts are positioned through the apertures of the attachment bracket and engage the threaded bores of nut plates positioned in the fastening channels of the cantilever arm. As a result, when the bolts are turned, the nut plates engage side walls of the fastening channels and the distal ends of the bolts engage a central pipe portion of the cantilever arm.

Abstract: Heuristics for resizing displayed objects within an electronic document are disclosed. The heuristics include resizing displayed objects to predefined ratios, resizing displayed objects by predefined increments, relating resizing of displayed objects to a global reference grid, and resizing a plurality of displayed objects aligned to an axis.

Abstract: A method for scrolling a multi-section document is disclosed, including displaying on a display an electronic document that includes a plurality of document sections separated by respective logical structure boundaries; detecting a gesture on a touch-sensitive surface, the gesture having an initial velocity that exceeds a predefined speed threshold such that the gesture will scroll the electronic document more than one document section; initiating scrolling of the electronic document on the display at the initial velocity in accordance with an initial scrolling speed versus scrolling distance function; while scrolling the electronic document, adjusting the scrolling speed versus scrolling distance function so that when the scrolling speed becomes zero, a first logical structure boundary in the electronic document is displayed at a predefined location on the display; and, scrolling the electronic document in accordance with the adjusted scrolling speed versus scrolling distance function.

Abstract: A cantilever assembly includes a cantilever arm having longitudinal fastening channels and slots in communication with the fastening channels. The assembly also includes an attachment bracket featuring a first leg portion and a second leg portion defining a seat there between with the leg portions featuring apertures. Bolts having threaded shafts are positioned through the apertures of the attachment bracket and engage the threaded bores of nut plates positioned in the fastening channels of the cantilever arm. As a result, when the bolts are turned, the nut plates engage side walls of the fastening channels and the distal ends of the bolts engage a central pipe portion of the cantilever arm.

Abstract: The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for accelerating protein aggregate clearance in the CNS, e.g., for treating diseases that are characterized by protein aggregation—including some degenerative neurological diseases such as Parkinson's disease. In one aspect, the compositions of the invention specifically target synuclein, beta-amyloid and/or tau protein aggregates, and the methods of the invention can be used to specifically prevent, reverse, slow or inhibit synuclein, beta-amyloid and/or tau protein aggregation. In alternative embodiments, the compositions and methods of the invention, are used to treat, prevent, reverse (partially or completely) or ameliorate (including slowing the progression of) degenerative neurological diseases related to or caused by protein aggregation, e.g., synuclein, beta-amyloid and/or tau protein aggregation.

Abstract: A method for scrolling a multi-section document is disclosed, including displaying on a display an electronic document that includes a plurality of document sections separated by respective logical structure boundaries; detecting a gesture on a touch-sensitive surface, the gesture having an initial velocity that exceeds a predefined speed threshold such that the gesture will scroll the electronic document more than one document section; initiating scrolling of the electronic document on the display at the initial velocity in accordance with an initial scrolling speed versus scrolling distance function; while scrolling the electronic document, adjusting the scrolling speed versus scrolling distance function so that when the scrolling speed becomes zero, a first logical structure boundary in the electronic document is displayed at a predefined location on the display; and, scrolling the electronic document in accordance with the adjusted scrolling speed versus scrolling distance function.

Abstract: A method is performed at a multifunction device with a display and a touch-sensitive surface. The method includes: displaying a first user interface for an application at a first magnification level. The first user interface includes a first plurality of user interface objects. The application has a range of magnification levels, including a predefined magnification level for requesting a second user interface with a multi-finger pinch gesture.

Abstract: A method for scrolling a multi-section document is disclosed, including displaying on a display an electronic document that includes a plurality of document sections separated by respective logical structure boundaries; detecting a gesture on a touch-sensitive surface, the gesture having an initial velocity that exceeds a predefined speed threshold such that the gesture will scroll the electronic document more than one document section; initiating scrolling of the electronic document on the display at the initial velocity in accordance with an initial scrolling speed versus scrolling distance function; while scrolling the electronic document, adjusting the scrolling speed versus scrolling distance function so that when the scrolling speed becomes zero, a first logical structure boundary in the electronic document is displayed at a predefined location on the display; and, scrolling the electronic document in accordance with the adjusted scrolling speed versus scrolling distance function.

Abstract: Methods for touch-based gestural command input on a device with a touch-sensitive surface and a display are disclosed. In one embodiment, a method includes displaying an electronic canvas including an object at a first magnification level; simultaneously detecting a first and a second contact on the touch-sensitive surface, wherein at least one of the first contact and the second contact on the touch-sensitive surface is at a location that corresponds to a location on the display that is away from the object; detecting a gesture made with the first and second contacts; when a velocity of the gesture is less than a predefined gesture velocity threshold, scaling the electronic canvas in accordance with the gesture; and, when the velocity of the gesture is greater than the predefined gesture velocity threshold transitioning the electronic canvas from the first magnification level to a second, predefined magnification level in response to the gesture.

Abstract: A computing device with a display simultaneously displays a plurality of user interface objects, a currently selected user interface object, and a plurality of resizing handles for the currently selected user interface object. Each respective resizing handle has a corresponding handle activation region with a default position relative to the respective resizing handle, a default size, and a default shape. The device detects a first input on a first handle activation region for a first resizing handle in the plurality of resizing handles. In response to detecting the first input, the device: resizes the currently selected user interface object, and for at least one resizing handle in the plurality of resizing handles, modifies a corresponding handle activation region by changing the position of the handle activation region relative to the resizing handle from the default position to a modified position.

Abstract: A computing device with a display simultaneously displays a plurality of user-repositionable user interface objects with one or more activation regions. The device receives a first input from the user. Based at least in part on the first input, the device determines a first plurality of candidate actions for manipulating a user interface object. The device performs a first candidate action of the first plurality of candidate actions as determined in accordance with the first ordering. After performing the first candidate action, the device undoes the first candidate action, receives a third input that is a repetition of the first input, and determines a second plurality of candidate. The second plurality of candidate actions is ordered such that second candidate action in the second plurality of candidate actions has a higher position than the first candidate action in the second ordering. The device performs the second candidate action.

Abstract: A computing device with a touch screen display simultaneously displays on the touch screen display a plurality of user interface objects displayed at a first magnification level in a display area. The device detects a first contact on a first handle activation region for a first handle of a user interface object. In response to continuing to detect the first contact at for a predefined amount of time, the device zooms the display area to a second magnification level. While the display area is at the second magnification level, the device: detects a movement of the first contact across the touch screen display; moves the first handle in accordance with the detected movement of the first contact; and detects liftoff of the first contact. In response to detecting liftoff of the first contact, the device zooms the display area to the first magnification level.

Abstract: Heuristics for resizing displayed objects within an electronic document are disclosed. The heuristics include resizing displayed objects to predefined ratios, resizing displayed objects by predefined increments, relating resizing of displayed objects to a global reference grid, and resizing a plurality of displayed objects aligned to an axis.

Abstract: The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for accelerating protein aggregate clearance in the CNS, e.g., for treating diseases that are characterized by protein aggregation—including some degenerative neurological diseases such as Parkinson's disease. In one aspect, the compositions of the invention specifically target synuclein, beta-amyloid and/or tau protein aggregates, and the methods of the invention can be used to specifically prevent, reverse, slow or inhibit synuclein, beta-amyloid and/or tau protein aggregation. In alternative embodiments, the compositions and methods of the invention, are used to treat, prevent, reverse (partially or completely) or ameliorate (including slowing the progression of) degenerative neurological diseases related to or caused by protein aggregation, e.g., synuclein, beta-amyloid and/or tau protein aggregation.

Abstract: Heuristics for resizing displayed objects within an electronic document are disclosed. The heuristics include resizing displayed objects to predefined ratios, resizing displayed objects by predefined increments, relating resizing of displayed objects to a global reference grid, and resizing a plurality of displayed objects aligned to an axis.

Abstract: A method for modifying user interface behavior on a device with a touch-sensitive surface and a display includes: displaying a user interface; while simultaneously detecting a first and a second point of contact on the touch-sensitive surface, wherein the first and second points of contact define a perimeter of a circle: detecting a first portion of a first gesture made with at least one of the points of contact on the touch-sensitive surface; performing a first responsive behavior in accordance with the first gesture; detecting a second gesture which deviates from the perimeter of the circle; performing a second responsive behavior in response to the second gesture; detecting a second portion of the first gesture; and, performing a third responsive behavior in accordance with the second portion of the first gesture, wherein the third responsive behavior is different from the first responsive behavior.

Abstract: A method for modifying user interface behavior on a device with a touch-sensitive surface and a display includes displaying a user interface, and while detecting a contact on the touch-sensitive surface: detecting a first movement of the contact corresponding to a first portion of a first gesture; performing a first responsive behavior in accordance with the first portion of the first gesture; detecting a second movement of the contact corresponding to a second gesture; performing a second responsive behavior in response to the second gesture, wherein the second responsive behavior is different from the first responsive behavior; detecting a third movement of the contact, wherein the third movement corresponds to a second portion of the first gesture; and performing a third responsive behavior in accordance with the second portion of the first gesture. The third responsive behavior is different from the first responsive behavior.

Abstract: A computing device with a touch screen display simultaneously displays on the touch screen display a plurality of user interface objects displayed at a first magnification level in a display area. The device detects a first contact on a first handle activation region for a first handle of a user interface object. In response to continuing to detect the first contact at for a predefined amount of time, the device zooms the display area to a second magnification level. While the display area is at the second magnification level, the device: detects a movement of the first contact across the touch screen display; moves the first handle in accordance with the detected movement of the first contact; and detects liftoff of the first contact. In response to detecting liftoff of the first contact, the device zooms the display area to the first magnification level.

Abstract: A computing device with a display simultaneously displays a plurality of user interface objects, a currently selected user interface object, and a plurality of resizing handles for the currently selected user interface object. Each respective resizing handle has a corresponding handle activation region with a default position relative to the respective resizing handle, a default size, and a default shape. The device detects a first input on a first handle activation region for a first resizing handle in the plurality of resizing handles. In response to detecting the first input, the device: resizes the currently selected user interface object, and for at least one resizing handle in the plurality of resizing handles, modifies a corresponding handle activation region by changing the position of the handle activation region relative to the resizing handle from the default position to a modified position.