Abstract: The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be encountered, for example, in scanning label-independent-detection biosensor applications.

Abstract: A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based sensor. Approximate to each sensor is a mask having an aperture of predetermined size. The aperture regulates the light that enters and exits the sensor upon successive scans and ensures repeatable readings from the sensor. In an extended embodiment, a method of detection is disclosed that utilizes a launch and receive system while employing the aforementioned microplate.

Abstract: A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.

Abstract: A system and a method as defined herein for scan interrogation of, for example, a label-independent-detection (LID) biosensor, such as for monitoring a surface change or an event on a biosensor for use, for example, in microplate image analysis.

Abstract: The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be encountered, for example, in scanning label-independent-detection biosensor applications.

Abstract: The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be encountered, for example, in scanning label-independent-detection biosensor applications.

Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

Abstract: A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.

Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

Abstract: The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be encountered, for example, in scanning label-independent-detection biosensor applications.

Abstract: A system and a method as defined herein for scan interrogation of, for example, a label-independent-detection (LID) biosensor, such as for monitoring a surface change or an event on a biosensor for use, for example, in microplate image analysis.

Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

Abstract: The present invention provides an apodization mask that narrows the central lobe of an optical image of a point in a focusing system and suppresses the amplitudes of the sidelobes of the image that are within a predetermined radius of the central axis of the sidelobes, thereby improving resolution of point objects that are relatively close together and presenting better images of small objects.

Abstract: A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based sensor. Approximate to each sensor is a mask having an aperture of predetermined size. The aperture regulates the light that enters and exits the sensor upon successive scans and ensures repeatable readings from the sensor. In an extended embodiment, a method of detection is disclosed that utilizes a launch and receive system while employing the aforementioned microplate.

Abstract: An athermal interferometric wavelocker is disclosed having a beam splitter combiner and a first arm of a first material having a first refractive index, a first length, and a first coefficient of expansion; and, a second arm of a second material having a second refractive index, a second length, and a second coefficient of expansion. The refractive indices, lengths and coefficients of expansion of the first arm and the second arm are selected to provide a substantially athermal structure operating at ambient temperatures. The first arm and second arm have inner end faces that meet adjacent faces of the beam splitter and combiner. The first and second arms are of a different optical path length such that light launched into the beam splitter and combiner, interferes upon recombining, and is output from a combiner output port to provide a wavelocker signal having a detectable characteristic which varies with wavelength.

Abstract: The present invention provides an apodization mask that narrows the central lobe of an optical image of a point in a focusing system and suppresses the amplitudes of the sidelobes of the image that are within a predetermined radius of the central axis of the sidelobes, thereby improving resolution of point objects that are relatively close together and presenting better images of small objects.

Abstract: The invention relates to a receiver optical sub-assembly (ROSA) for use in an optical transceiver to convert optical signals transmitted along an optical fiber into electrical signals for use by a host device. Conventionally, light exiting the optical fiber inside an optical coupler of the ROSA encounters a refractive index mismatched interface, e.g. fiber/air, causing a portion of the light to be reflected directly back into the fiber. To minimize back reflections at the interface with the optical fiber, an optical insert is provided having an index of refraction matching that of the optical fiber, thereby moving the mismatched interface remote from the end of the fiber to an interface of the optical insert and a lens, to which the optical insert is attached.

Abstract: Filter gratings are formed in optical waveguides having photosensitive cores by exposing the cores to actinic radiation in the form of interfering beams having peak intensities that are relatively displaced along an optical axis of the waveguides. Each of the interfering beams has a single-lobed intensity profile and a degree of spatial coherence required to achieve a desired fringe contrast between the two relatively displaced beams. Index modulations in the photosensitive core match the illumination (interference) pattern of the radiation. The relative displacement of the interfering beams reduces side lobes of the gratings' spectral responses by leveling the average refractive index of the index modulations. A second exposure with the two beams but without the beams' interference effects further levels the average refractive index.

Abstract: An athermal interferometric wavelocker is disclosed having a beam splitter combiner and a first arm of a first material having a first refractive index, a first length, and a first coefficient of expansion; and, a second arm of a second material having a second refractive index, a second length, and a second coefficient of expansion. The refractive indices, lengths and coefficients of expansion of the first arm and the second arm are selected to provide a substantially athermal structure operating at ambient temperatures. The first arm and second arm have inner end faces that meet adjacent faces of the beam splitter and combiner. The first and second arms are of a different optical path length such that light launched into the beam splitter and combiner, interferes upon recombining, and is output from a combiner output port to provide a wavelocker signal having a detectable characteristic which varies with wavelength.