Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A method and system for serving assets is disclosed, comprising receiving an asset request to serve an asset, wherein the asset request originates at an application, and wherein the asset request comprises an advertisement of an asset to be served and a request for the network address of an asset server configured to serve the requested asset. The method further comprises causing a service discovery server to identify an asset server configured to serve the requested asset, and causing the requested asset to be served to the application.

Abstract: In some aspects, a method of carbonation control can include monitoring, via a first sensor, an environmental condition in a contactor unit, the contactor unit including a plurality of carbonation vessels including carbonation medium, monitoring, via a second sensor, an environmental condition at a location outside of the contactor unit, predicting, based on the measured environmental condition in the contactor unit and the measured environmental condition at the location outside of the contactor unit, a local humidity in a carbonation vessel from the plurality of carbonation vessels, a water content of the carbonation medium in the carbonation vessel from the plurality of carbonation vessels, and a carbonation extent of the carbonation medium in the carbonation vessel from the plurality of carbonation vessels for a carbonation forecasting period, and executing an action on the plurality of carbonation vessels based on the predicted water content and predicted carbonation extent.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: The present invention provides a lightweight glove for baseball or softball that may include an elastic backfinger to provide a conforming fit to the wearer's hand. In general, the elastic backfinger may replace existing, often leather backfingers, the back panel, the liner, and/or other elements of traditional gloves glove with the elastic material, combination of elastic materials, or combination of elastic and inelastic materials.

Abstract: A method of treating viral infection, such as viral infection caused by a virus of the Coronaviridae family, is provided. A composition having at least oleandrin or digoxin is used to treat the viral infection or the disease state of said viral infection.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A lightweight, breathable glove for baseball or softball is provided that generally includes a strap that extends over at least a portion of an opening in which a wearer may place his or her hand. The strap is at least partially made of an elastic material so that the strap can extend and contract. The glove may thus have a reduced weight to provide superior ease of use. Further, the conforming fit of the glove provides for enhanced control of the glove, which provides superior utility and performance for the glove, as well as other advantages. Alternatively, the glove may include a thong which may extend from the glove and may engage an elastic band at one of its ends. Thus, the elastic band may engage both the glove and the thong so that the size of the opening can increase and decrease due to the strap and/or elastic band.

Abstract: Flow diverters for installation in mid-turbine frame systems at a conduit outlet of gas turbine engines are described. The flow diverters include a diverter body having a connector portion defining a diverter inlet, a diverter extension at least partially defining a diverter outlet, and a curved portion arranged between the connector portion and the diverter extension, the curved portion configured to change a direction of flow from a first direction to a second direction that is about 90° from the first direction as the flow passes from the diverter inlet to the diverter outlet.

Abstract: An intelligent supply-chain wide tracking and analysis system is described. In some instances, the system may receive variant data describing a variant of a product from a first client system, generate a variant profile based on the variant data, and determine a connection definition specific to the variant profile and defining a connection between the first client system and a second system. The system may provide access to a first data field containing data in the client profile from the first client system to the second client system based on the connection definition. The system may also receive an inventory value for the variant from the second client system and, using the variant profile and connection definition, provide access to the inventory value to the first client system.

Abstract: A subcritical liquid extraction process for the production of oleandrin or oleandrin-containing extract is provided. The process provides improvements over other methods of preparing oleandrin-containing extract. The extract, pharmaceutical compositions, dosage forms and nutraceutical compositions comprising oleandrin or said extract are provided. Methods of treating diseases, disorders or conditions that are therapeutically responsive to oleandrin are also provided.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A cryogenic cooling manifold and methods incorporating a cryogenic cooling manifold for managing the gas layer(s) above a liquid cryogen to control cooling temperature-time profiles and ice formation for microliter and smaller samples that are plunged through the gas and into the liquid cryogen.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A method of treating glioma is provided. A combination protocol as described herein includes radiotherapy, chemotherapy, and pharmacotherapy. Resection of the glioma is optionally included in the combination protocol. Pharmacotherapy is conducted with an oleandrin-containing composition. Treatment of glioblastoma is particularly contemplated.

Abstract: A cryogenic cooling manifold and methods incorporating a cryogenic cooling manifold for managing the gas layer(s) above a liquid cryogen to control cooling temperature-time profiles and ice formation for microliter and smaller samples that are plunged through the gas and into the liquid cryogen.

Abstract: The present invention provides a lightweight glove for baseball or softball that may include an elastic backfinger to provide a conforming fit to the wearer's hand. In general, the elastic backfinger may replace existing, often leather backfingers, the back panel, the liner, and/or other elements of traditional gloves glove with the elastic material, combination of elastic materials, or combination of elastic and inelastic materials.

Abstract: An air seal assembly for a gas turbine includes a flow path platform. The air seal assembly further includes a casing disposed radially outside the flow path platform. The air seal assembly further includes an annular finger seal mounted to the casing and disposed between the flow path platform and the casing. The annular finger seal includes a first circumferential portion mounted to the casing, a second circumferential portion extending from the first circumferential portion, and a third circumferential portion extending from the second circumferential portion and contacting an outer surface of the flow path platform. The third circumferential portion includes a plurality of air cooling holes configured to direct a cooling air stream onto the flow path platform.