Abstract: The immune response to melanoma cells and tumors can be induced or significantly increased by administering to a subject a pharmaceutical composition comprising alphavirus particles, especially Venezuelan equine encephalitis virus replicon particles, which express the melanoma antigen dopachrome tautomerase (DCT, TRP2) in cells of the subject, with the result of tumor regression and/or inhibition of metastasis of a melanoma subject, or a decreased risk of the occurrence or recurrence of melanoma and/or decreased severity of melanoma in a subject not suffering from melanoma at the time of administration. The pharmaceutical composition described herein can be used in conjunction with other therapeutic agents, it can be administered on more than one occasion and it can be combined with administrations of other compositions such as protein or other immunogenic compositions, and/or adjuvants, with beneficial effects to the human or animal subject to which it has been administered.

Abstract: The immune response to melanoma cells and tumors can be induced or significantly increased by administering to a subject a pharmaceutical composition comprising alphavirus particles, especially Venezuelan equine encephalitis virus replicon particles, which express the melanoma antigen dopachrome tautomerase (DCT, TRP2) in cells of the subject, with the result of tumor regression and/or inhibition of metastasis of a melanoma subject, or a decreased risk of the occurrence or recurrence of melanoma and/or decreased severity of melanoma in a subject not suffering from melanoma at the time of administration. The pharmaceutical composition described herein can be used in conjunction with other therapeutic agents, it can be administered on more than one occasion and it can be combined with administrations of other compositions such as protein or other immunogenic compositions, and/or adjuvants, with beneficial effects to the human or animal subject to which it has been administered.

Abstract: The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising alphavirus replicon RNAs, wherein a first replicon RNA comprises nucleic acid encoding cytomegalovirus pp65 and IE1 protein or immunogenic fragments thereof, and a second replicon RNA comprises nucleic acid encoding cytomegalovirus gB protein or an immunogenic fragment thereof, and wherein each of the two replicon RNAs is contained within a separate alphavirus replicon particle.

Abstract: A data communication system providing for the secure transfer and sharing of data via a local area network and/or a wide area network. The system includes a secure processing unit which communicates with a personal keying device and a crypto media controller attached to a user's Workstation. The communication between these processing elements generates a variety of data elements including keys, identifiers, and attributes. The data elements are used to identify and authenticate the user, assign user security access rights and privileges, and assign media and device attributes to a data access device according to a predefined security policy. The data elements are manipulated, combined, protected, and distributed through the network to the appropriate data access devices, which prevents the user from obtaining unauthorized data.

Abstract: A method and apparatus for controlling model vehicles in a manner which accurately simulates the operation of real vehicles. Parameters relating to operational characteristics of a vehicle, environmental conditions, loading conditions, operator control settings, and physical characteristics of a controllable model are processed by a computer to determine appropriate control functions to a model allowing it to accurately replicate the operation of a real vehicle operating under the same set of conditions.

Abstract: A data communication system providing for the secure transfer and sharing of data via a local area network and/or a wide area network. The system includes a secure processing unit which communicates with a personal keying device and a crypto media controller attached to a user's Workstation. The communication between these processing elements generates a variety of data elements including keys, identifiers, and attributes. The data elements are used to identify and authenticate the user, assign user security access rights and privileges, and assign media and device attributes to a data access device according to a predefined security policy. The data elements are manipulated, combined, protected, and distributed through the network to the appropriate data access devices, which prevents the user from obtaining unauthorized data.