Abstract: Treatment of aneurysms can be improved by delivering an occlusive implant (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an expandable member that releasably engages the occlusive implant to an engagement portion of a conduit. When the expandable member is collapsed, the conduit is disengaged from a proximal hub of the occlusive implant. The conduit and expandable member may then be retracted while the occlusive implant remains at the treatment site.

Abstract: Systems, methods, and devices for treating vascular defects are disclosed herein. In some embodiments, a device for treating an aneurysm includes a plurality of braided filaments configured to be implanted in an aneurysm cavity.

Abstract: Systems, methods, and devices for treating vascular defects are disclosed herein. In some embodiments, a method of treating an aneurysm includes positioning a distal portion of an elongated member near or within an aneurysm. The method can include introducing an embolic composition into a lumen of the elongated member using an injector device coupled to a proximal portion of the elongated member. The injector device can pressurize the embolic composition to a pressure of at least 10,000 psi. The method can also include delivering the embolic composition into the aneurysm via the elongated member.

Abstract: Devices for treating vascular defects and associated systems and methods are disclosed herein. In some embodiments, for example, an occlusive device for treating an aneurysm includes a first mesh formed from a first tubular braid, the first mesh including a first petal-shaped region formed from a first flattened section of the first tubular braid. The first mesh can be coupled to a second mesh formed from a second tubular braid. The second mesh can include a second petal-shaped region formed from a second flattened section of the second tubular braid. When the occlusive device is deployed within the aneurysm, the first and second petal-shaped regions can extend at least partially over a neck of the aneurysm.

Abstract: A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Abstract: A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Abstract: A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Abstract: A bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Abstract: A method of implanting a bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Abstract: A bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Abstract: A method of implanting a bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Abstract: A bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Abstract: A bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Abstract: A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Abstract: A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Abstract: A bridging device for supporting occlusive masses within an aneurysm located at a vascular bifurcation.

Abstract: A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Abstract: A miniaturized obstruction treatment device, e.g., a resilient brush, particularly adapted for medical use formed at the distal end of an elongated brush drive shaft having a hollow lumen formed therein for introduction over a guidewire. The brush drive shaft is enclosed in the lumen of a brush delivery catheter, and the brush is adapted to be garaged in a distal end section of the brush delivery catheter lumen. A Y-connector and a brush sub-assembly connector are attached to the proximal end of the brush delivery catheter and form a brush sub-assembly with the brush drive shaft and brush. The Y-connector allows infusion of thrombolytic agents into the brush delivery catheter lumen for emission at the distal end opening thereof adjacent the brush. In use, the brush sub-assembly connector connects the brush sub-assembly with a drive motor unit connector of a drive motor unit. The drive motor unit receives the proximal end of the drive shaft and rotates it to rotate the brush bristles.

Abstract: A miniaturized brush particularly adapted for medical use formed at the distal end of an elongated brush drive shaft having a hollow lumen formed therein for introduction over a guidewire. The brush drive shaft is enclosed in the lumen of a brush delivery catheter and other components of a brush sub-assembly adapted to deliver infusate through the catheter lumen and to be coupled to a drive motor unit for rotating the brush drive shaft and brush. The brush bristles of the distal brush are adapted to be garaged in a distal end section of the brush delivery catheter lumen during introduction through a body lumen. The brush bristles are formed of a thin sheet of rigid plastic material that is shaped to have a plurality of fringe elements extending in parallel from a mounting web. The mounting web is wound about and attached to a distal end section of the drive shaft outer circumference so that the fringe elements extend outward from the drive shaft surface and obliquely of the drive shaft axis.