Abstract: The invention provides improved anti-BCMA CAR T cell compositions for adoptive T cell therapy for relapsed/refractory multiple myeloma.

Abstract: The invention apparatus for and a method of creating a localized warning to prevent damage to buried pipeline and other buried infrastructure using a new type of marker tape with the trade name signal tape® [hereinafter referred to as “Signal Tape”]. The disclosed Signal Tape may incorporate tracer wire and RFID technology to aid in the remote location of the Signal Tape and, thus, the buried infrastructure. Signal Tape may also incorporate Litz wire for use as tracer wire within the Signal Tape. The Signal Tape is designed to be buried just below the surface of the ground and directly over a buried infrastructure such as a pipeline. The Signal Tape incorporates a strong core material which permits the Signal Tape to be bodily removed from the soil when it is struck by excavation equipment.

Abstract: The present disclosure relates to methods of treating cancer comprising administering to a subject an anti-IL-27 antibody and pembrolizumab.

Abstract: The present disclosure relates to methods of treating cancer comprising administering to a subject an anti-IL-27 antibody, atezolizumab, and bevacizumab.

Abstract: This application discloses a system that may comprise at least a portion of a supply network. The system may further comprise a load controller that controls current flow with a current level of I1 into a load network that provides power to one or more loads from the at least a portion of the supply network according to a preprogrammed load curve. The system may also comprise a protection system that isolates the at least a portion of the supply network from the load controller in response to detecting a current pattern that is inconsistent with the preprogrammed load curve.

Abstract: A fixture for supporting an article (e.g., a guitar such as a Stratocaster® guitar body) and controlling the position of the article relative to a print head to allow a contoured portion of a surface of the article to be printed by the print head. The fixture may include a pivot axis about which the article is pivotal. A cam surface may be engaged by the article and/or a bracket of the fixture to which the article is affixed to prescribe the controlled movement of the article based on relative movement between the article and the print head. In turn, both planar and contoured portions of the guitar surface may be printed during a single print operation.

Abstract: This application discloses a system that may comprise at least a portion of a supply network. The system may further comprise a load controller that controls current flow with a current level of I1 into a load network that provides power to one or more loads from the at least a portion of the supply network according to a preprogrammed load curve. The system may also comprise a protection system that isolates the at least a portion of the supply network from the load controller in response to detecting a current pattern that is inconsistent with the preprogrammed load curve.

Abstract: A downhole multi-modality inspection system includes a first imaging device operable to generate first imaging data and a second imaging device operable to generate second imaging data. The first imaging device includes a first source operable to emit energy of a first modality, and a first detector operable to detect returning energy induced by the emitted energy of the first modality. The second imaging device includes a second source operable to emit energy of a second modality, and a second detector operable to detect returning energy induced by the emitted energy of the second modality. The system further includes a processor configured to receive the first imaging data and the second imaging data, and integrate the first imaging data with the second imaging data into an enhanced data stream. The processor correlates the first imaging data and the second imaging data to provide enhanced data for detecting potential wellbore anomalies.

Abstract: A fixture for supporting an article (e.g., a guitar such as a Stratocaster® guitar body) and controlling the position of the article relative to a print head to allow a contoured portion of a surface of the article to be printed by the print head. The fixture may include a pivot axis about which the article is pivotal. A cam surface may be engaged by the article and/or a bracket of the fixture to which the article is affixed to prescribe the controlled movement of the article based on relative movement between the article and the print head. In turn, both planar and contoured portions of the guitar surface may be printed during a single print operation.

Abstract: The invention provides methods and uses of treating cancer with and IgG4 anti-CD39_229p antibody in combination with pembrolizumab, wherein the IgG4 anti-CD39_229p antibody is provided at particular doses and dosages.

Abstract: The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof at a dose of at least about 0.003 mg/kg to at least about 20 mg/kg.

Abstract: The invention provides methods of treating cancer using an anti-CD39 antibody or fragment thereof as monotherapy or in combination with other therapies at particular dosages and frequencies.

Abstract: A wellbore completion system includes an expandable liner hanger with a post-setting fluid flow path. The system includes an expandable liner hanger that can be expanded by a running tool prior to a completion operation in a wellbore. The system also includes a circulating sleeve that can be manipulated by the running tool. The circulating sleeve can provide a return path for fluid internal to the expandable liner hanger for the completion operation that is performed subsequent to releasing the running tool from the expandable liner hanger.

Abstract: A kit for preparing a nucleic acid sample for analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) is provided, the kit comprising: a lyophilized enzyme composition comprising: micrococcal nuclease; nuclease P1; and bacterial alkaline phosphatase (BAP); and a digestion buffer. Also provided are enzyme compositions and methods of use for rapid, efficient preparation of a nucleic acid sample for analysis by LC-MS/MS, without the need for denaturation of the sample.

Abstract: Multi-mode management systems are disclosed. Such systems include a first controller and a second controller. The first controller can be configured to control a power system. The second controller can have two modes. The second controller can be configured to, when in a first mode, estimate a state of the power system by monitoring communications between the first controller and the power system, and in response to satisfaction of a first condition, switch to the second mode. The second controller can be configured to, when in the second mode, disable communication between the first controller and the power system and control the power system based on the estimated state of the power system.

Abstract: Technology is disclosed for proactively enriching content of electronic communications through predicting user intents. User-composed content within an electronic communication is observed and used to predict one or more intents each associated with a task related to the communication and to be completed in creating the communication. Task-queries may be generated based on the detected intents and entities extracted from the user-composed content, contextual information, or other information related to the user, such as a user-knowledge database. User selection of a suggested task-query automatically executes the task-query, and the results are provided to the user. Each result may include an action involving adding content to or supplementing the content of the electronic communication. A conversational digital assistant may further be invoked to interact with the user to confirm and/or modify suggested task-queries and results of selected task-queries.

Abstract: The present disclosure relates to the use of X-ray detector cassettes that may be abutted or overlapped to form a detector assembly suitable for imaging objects that are too large to image using a single X-ray detector cassette. Such a detector assembly may be customized in terms of the size and/or shape of the field-of-view (FOV). In certain embodiments the radiation-sensitive electronics (e.g., readout electronics) are positioned to the side of the X-ray detecting components (e.g., scintillator, TFT array, and so forth), allowing the cassette to be thin relative to other detector devices and allowing the electronics to remain outside the X-ray beam path.

Abstract: A fixture for supporting an article (e.g., a guitar such as a Stratocaster® guitar body) and controlling the position of the article relative to a print head to allow a contoured portion of a surface of the article to be printed by the print head. The fixture may include a pivot axis about which the article is pivotal. A cam surface may be engaged by the article and/or a bracket of the fixture to which the article is affixed to prescribe the controlled movement of the article based on relative movement between the article and the print head. In turn, both planar and contoured portions of the guitar surface may be printed during a single print operation.

Abstract: Techniques are disclosed for digitizing a framework for clinical development. In one example, a computing device comprising a memory configured to store a study and a processor may be configured to perform the techniques. The processor may receive, from a user, an input specifying a plurality of trial elements for the study, and receive, from the user, an input arranging the plurality of trial elements into a tree data structure. The processor may also determine, based on the tree data structure of the plurality of trial elements, one or more trial arms for the study, each trial arm of the one or more trial arms comprising a single path between at least one trial element of the plurality of trial elements to at least one other trial element of the plurality of trial elements. The processor may further output, for display, the one or more trial arms for the study.

Abstract: A computing device comprising a processor is configured to perform the techniques of this disclosure. The processor may duplicate a first node of a tree data structure to create a duplicate node, and create an inbound edge of the duplicate node to a parent node of the first node and an outbound edge to at least one child node of the first node. The processor may receive an update to the at least one child node of the first node. In response to determining that the at least one child node has multiple parent nodes, the processor may duplicate the at least one child node to create a duplicate child node, create an outbound edge of the duplicate node to the duplicate child node, delete the outbound edge of the duplicate node to the at least one child node, and perform the update to the at least one child node.