Patents by Inventor Robert A. Saxton

Robert A. Saxton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying modulators of CASTOR1-GATOR2 interaction and use of same to modulate mTORC1
    Patent number: 11092608
    Abstract: The invention relates to methods of identifying compounds that modulate mTORC1 activity in a cell by modulating the activity of CASTOR1, as well as to the use of such identified compounds in the modulation of mTORC1 and the treatment of diseases and conditions characterized by aberrant mTORC1 activity.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: August 17, 2021
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Lynne Chantranupong, Robert A. Saxton, Steven P. Gygi, Melanie P. Gygi
  • METHODS OF IDENTIFYING MODULATORS OF CASTOR1-GATOR2 INTERACTION AND USE OF SAME TO MODULATE mTORC1
    Publication number: 20190025321
    Abstract: The invention relates to methods of identifying compounds that modulate mTORC1 activity in a cell by modulating the activity of CASTOR1, as well as to the use of such identified compounds in the modulation of mTORC1 and the treatment of diseases and conditions characterized by aberrant mTORC1 activity.
    Type: Application
    Filed: December 28, 2016
    Publication date: January 24, 2019
    Inventors: David M. Sabatini, Lynne Chantranupong, Robert A. Saxton, Steven P. Gygi, Melanie P. Gygi
  • Methods of identifying modulators of sestrin-gator-2 interaction for modulating mTORC1 activity
    Patent number: 10168338
    Abstract: The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: January 1, 2019
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Lynne Chantranupong, Rachel L. Wolfson, Jose Orozco, Robert A. Saxton, Shomit Sengupta
  • METHODS OF IDENTIFYING MODULATORS OF SESTRIN-GATOR-2 INTERACTION AND USE OF SAME TO MODULATE mTORC1
    Publication number: 20170285043
    Abstract: The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.
    Type: Application
    Filed: September 11, 2015
    Publication date: October 5, 2017
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Lynne Chantranupong, Rachel L. Wolfson, Jose Orozco, Robert A. Saxton, Shomit Sengupta