Abstract: The present disclosure relates to agonists of interferon alpha and beta receptor subunit 2 (IFNAR2) for use in the treatment or prevention of viral disease, particularly COVID-19. In particular embodiments, COVID-19 is associated with pneumonia or acute respiratory distress syndrome (ARDS). In other aspects, the subject being treated is undergoing extra-corporeal membrane oxygenation, mechanical ventilation, non-invasive ventilation, receiving oxygen therapy or receiving antiviral or steroid treatment.

Abstract: Provided herein are methods for treatment, prevention, or amelioration of one or more symptoms of a disease or condition related to disorders of insulin and/or glucose metabolism, inflammatory conditions, mitochondrial disease, muscle disorders, or pulmonary disorders, involving administering a PPAR? agonist or a pharmaceutical composition comprising a PPAR? agonist. In one embodiment, the disease or condition is selected from myopathy, inflammatory vascular diseases, Parkinson's and Alzheimer's diseases, systemic inflammatory disorders, renal ischemia, inflammatory rheumatic disorders, and inflammatory diseases of the lung. In another embodiment, methods for increasing oxidative muscle fibers, reducing mitochondria disease, decreasing insulin resistance, decreasing plasma glucose, or decreasing weight, involving administering a PPAR? agonist or a pharmaceutical composition comprising a PPAR? agonist, are provided.

Abstract: Provided are pharmaceutical compositions and methods for preventing or reducing niacin-induced flushing comprising an aspirin component and a niacin component having different release profiles. Also provided are methods and compositions for preventing or reducing niacin-induced flushing comprising niacin, aspirin and a lipid-lowering drug other than niacin.

Abstract: A prosthesis to be implanted within a bone comprises a shell and a liner that fits within the shell. The shell comprises a bone engaging region which terminates at a first plane, and a non-bone engaging region which extends out of the first plane and at least partially defines an open mouth of the shell.

Abstract: A prosthesis to be implanted within a bone comprises a shell and a liner that fits within the shell. The shell comprises a bone engaging region which terminates at a first plane, and a non-bone engaging region which extends out of the first plane and at least partially defines an open mouth of the shell.

Abstract: The invention provides a drug delivery system for delivering a drug to either the small intestine (enteric) or the colon comprising a HPMC capsule containing the drug and wherein the HPMC capsule is provided with a suitable coating such that the drug is released from the capsule either in the small intestine or the colon.

Abstract: The invention concerns polyvinyl alcohol (PVA) compositions for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. Compared with hard gelatine capsules (HGC) capsule films consisting of PVA have extremely low water vapour permeability and much lower water content.

Abstract: The invention concerns compositions from modified starches, such as starch ethers or oxidized starch, more particularly hydroxpropylated starch (HPS) or hydroxylethylated starch (HES) for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. The hard capsules obtained by the present invention with a conventional dipping molding process are similar to hard gelatine capsules (HGC).

Abstract: Foldable intraocular lenses having a reduced risk of posterior capsule opacification are disclosed. The foldable intraocular lenses have optics that are prepared such that their surface is glassy and their bulk is rubbery.

Abstract: The invention concerns compositions from modified starches, such as starch ethers or oxidized starch, more particularly hydroxpropylated starch (HPS) or hydroxylethylated starch (HES) for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. The hard capsules obtained by the present invention with a conventional dipping molding process are similar to hard gelatine capsules (HGC).

Abstract: The invention concerns compositions from modified starches, such as starch ethers or oxidized starch, more particularly hydroxpropylated starch (HPS) or hydroxylethylated starch (HES) for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. The hard capsules obtained by the present invention with a conventional dipping molding process are similar to hard gelatine capsules (HGC).

Abstract: The invention concerns polyvinyl alcohol (PVA) compositions for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. Compared with hard gelatine capsules (HGC) capsule films consisting of PVA have extremely low water vapour permeability and much lower water content.

Abstract: A video cassette reminder system that provides storage for viewed video cassettes with a signaling system as a reminder that the rented video(s) is due to be returned. The video cassette reminder system eliminates late charges.

Abstract: The invention provides a drug delivery system for delivering a drug to either the small intestine (enteric) or the colon comprising a HPMC capsule containing the drug and wherein the HPMC capsule is provided with a suitable coating such that the drug is released from the capsule either in the small intestine or the colon.

Abstract: A programmable automatic feeder for pets and other animals dispenses a measured amount of food at a predetermined time. A digital clock control mechanism, including an adjustable portion control knob, controls the energization of a battery-operated motor. The motor drives an eccentric weight to vibrate a vibrating conveyor pan attached to the motor. The vibrating conveyor pan is resiliently mounted on a fixed plate secured within the housing, and the vibrating conveyor pan is disposed below the open bottom portion of a hopper disposed within the housing. When the vibrating conveyor pan is vibrated, the food is dispensed rearwardly off the pan and into a curved chute. The food falls down the chute and is accessible to the animal through an opening in the front wall of the housing.

Abstract: An irrigation gravel guard is disclosed comprising a ring shaped support having a substantially conical shaped screen means secured thereto and extending therefrom. One end of the screen means is open and is secured to the ring shaped support by welding or the like. The other end of the screen means is rolled or crimped upon itself to substantially close the other end thereof except for the perforations extending therethrough. An extension screen for use with the gravel guard is also disclosed and comprises a pair of spaced apart ring shaped supports having a truncated conical shaped screen means secured thereto and extending therebetween. The extension may be welded to the end of the gravel guard so as to effectively increase the over-all length thereof.

Abstract: An irrigation pipe comprising a first elongated pipe portion, an intermediate pipe portion which extends at an angle from one end of the first pipe portion, and a second pipe portion extending from the intermediate pipe portion parallel to the first pipe portion. The ends of the first and second pipe portions are adapted to be connected to other irrigation pipes. A hollow tubular member is secured to the intermediate pipe portion and extends outwardly therefrom and is aligned with the central longitudinal axis of the first pipe portion. The interior of the tubular member is in communication with the interior of the intermediate pipe portion. A gravel screen is positioned in the first pipe portion and is substantially conical in shape with one end thereof being substantially equal in diameter to the interior of the first pipe portion. A pipe stub is secured to the other end of the gravel screen and extends therefrom through the tubular member in a sealed relationship with respect thereto.