Abstract: A vehicle includes a prime mover, a mixer drum assembly configured to selectively discharge a contents thereof, and a control system having a sensor. The control system is configured to detect, via the sensor, a state of a receiving device that is configured to receive the contents discharged from the mixer drum assembly, determine a desired state of the receiving device, adjust a vehicle state to reduce a difference between the state of the receiving device and the desired state of the receiving device, and cause a presentation of an indication of the adjustment of the vehicle state.

Abstract: A method of generating organic fertilizer material may include generating biologically produced sulfuric acid by passing an aqueous solution including sulfur over a material that may include sulfur oxidizing microorganisms. The operations may further include, recirculating the aqueous solution over the material until an amount of biologically produced sulfuric acid in the aqueous solution may reach a predefined threshold. The operations may further include extracting the biologically produced sulfuric acid from the aqueous solution. Further, the operations may include generating the organic fertilizer material using the extracted biologically produced sulfuric acid and an organic feedstock.

Abstract: The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Abstract: Absorbable 3D printed implants can be used to reconstruct the nipple with regenerated tissue resulting in improved aesthetic satisfaction. The implants are formed from parallel planes of filaments that are offset and bonded to each other to form macroporous networks (130) with open cell structures comprising cylindrical shapes. The macroporous network (130) may be enclosed by a shell (120) or coating, or may be at least partly filled with a hydrogel. The implants are particularly suitable for use in plastic surgery procedures, for example, to reconstruct the nipple following total mastectomy and breast reconstruction.

Abstract: The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Abstract: A frame apparatus for displaying an article. The frame apparatus includes a support structure having a frame and a backer panel. A plurality of slots are formed into the backer panel that include a first slot that is elongated along a first axis that is parallel to top and bottom edges of the support structure and a second slot that is elongated along a second axis that is parallel to lateral edges of the support structure. The frame apparatus may include a hanging element for hanging the support structure from a support surface such as a wall. The hanging element may be configured to be slidably coupled to the support structure such that the hanging element can slide back and forth within one of the slots while remaining coupled to the support structure. This structure enables the frame apparatus to move side-to-side along the support surface while hanging therefrom.

Abstract: In certain aspects, the disclosure provides ALK7 antagonists. In certain aspects, these ALK7 antagonists are can be used to improve metabolic parameters in a patient in need thereof. In certain aspects, these ALK7 antagonists can be used to treat or prevent one or more kidney-associated disease or condition in a patient in need thereof. In certain aspects, these ALK7 antagonists can be used to treat or prevent cancer.

Abstract: Examples disclosed herein relate to a gaming device including a memory, a processor, a display, and a call tower. The call tower extends upwardly from the gaming device, such as above the display. The call tower includes a call tower video display and may include one or more plates, such as light or image plates. The gaming device includes a processor which presents a game via the display and causes the plates and/or call tower video display to display information, such as images.

Abstract: According to at least one aspect of the present disclosure a car seat having an adjustable headrest is disclosed. The car seat comprises a shell; an adjustment portion coupled to the shell, the adjustment portion having a plurality of grooves; a headrest portion slidably coupled to the adjustment portion; at least one prong coupled to the headrest portion, the at least one prong configured to fit within a groove of the plurality of grooves; a handle; and a fixing member coupled to the handle, the fixing member being configured to retain the at least one prong in a fixed state.

Abstract: According to at least one aspect of the present disclosure a car seat release mechanism is provided. The car seat release mechanism comprises a shell; a first base connection mechanism coupled to the shell and configured to secure the shell to a car seat base, the first base connection mechanism having an open position and a closed position; a first stroller connection mechanism coupled to the shell and configured to secure the shell to a stroller, the first stroller connection mechanism having an open position and a closed position, the first stroller connection mechanism including a hook, a latch configured to receive a hook, a stroller securing portion, and a spring configured to bias the stroller securing portion in the closed position; and a handle coupled to an underside of the shell and configured to operate both the first base connection mechanism and the first stroller connection mechanism.

Abstract: A method is provided for generating single-stranded DNA circles from a biological sample. The method comprises the steps of: treating the biological sample with an extractant to release nucleic acids, thereby forming a sample mixture; neutralizing the extractant; denaturing the released nucleic acids to generate single-stranded nucleic acids; and contacting the single-stranded nucleic acids with a ligase that is capable of template-independent, intramolecular ligation of single-stranded DNA to generate the single-stranded DNA circles. All the steps of the method are performed without any intermediate nucleic acid isolation or nucleic acid purification. The single-stranded DNA circles may be amplified and further analyzed. Also provided is a kit which comprises compositions for carrying out the novel methods.

Abstract: In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine/threonine kinase receptor of the TGF-beta family and an extracellular domain of a type II serine/threonine kinase receptor of the TGF-beta family. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type II receptor selected from: ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type I receptor selected from: ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, cancerous cells, and/or cells of hematopoietic lineages, including red blood cells.

Abstract: Described herein are compositions and methods for preparing double-stranded complementary DNA (cDNA) from RNA. In some embodiments, these methods allow isothermal preparation of cDNA. In some embodiments, these methods allow mesophilic or thermostable preparation of cDNA. Also described herein are compositions and methods for preparing cDNA and a library of double-stranded cDNA fragments in a single reaction vessel.

Abstract: The present disclosure provides for the treatment of cardiac diseases and disorders using in vitro-differentiated cardiomyocytes. Such methods can take advantage of both autologous and allogeneic pluripotent stem cells.

Abstract: Aspects of the embodiments include receiving, from one or more telematics sensors in a vehicle and by the one or more data processing systems, a plurality of telematics data items that are sampled at a plurality of sample times. For a given sample time, accessing a given telematics data item that satisfies the one or more conditions, computing a fuel consumption amount at the given sample time, and determining a distance traveled by the vehicle from a previous sample time that is prior to the given sample time, to the given sample time. For each telematics data items that satisfies the conditions, computing a total distance and a total fuel consumption amount, with the computing based on distances traveled and fuel consumption amounts for the plurality of telematics data items; and determining a fuel efficiency score the total fuel consumption amount and the total distance or a total time.

Abstract: A cover for an eating utensil having a head opposite a handle. The cover has a sleeve with a closed end and an open end for receiving the head of the eating utensil. A tab extends from the open end of the sleeve. The tab may have an adhesive on an inner side for adhering the tab to a portion of the handle when the head is positioned in the sleeve.

Abstract: In an aspect, a latch for a closure panel for a vehicle is provided, and includes a ratchet, pawl, release lever, and extension member. The ratchet is movable between a primary closed position, secondary closed position and open position. The pawl is movable between a primary locking position, secondary locking position and unlocking position. The release lever is movable between home and actuated positions. When the pawl is in the primary locking position the release lever has a selected amount of reach for driving the pawl to the secondary locking position during movement of the release lever to the actuated position. When the pawl is in the secondary locking position the extension member is movable to extend the reach of the release lever to drive the pawl from the secondary locking position to the unlocked position during movement of the release lever from the home position to the actuated position.

Abstract: Compounded virgin low density polyethylene (virgin LDPE) and post-consumer recyclate low density polyethylene, linear low density polyethylene or a combination of low and linear low density polyethylene compositions with improved processability and mechanical properties, including processes of making, products and application in food and non-food packaging are described herein.

Abstract: The present disclosure relates to a synthetic Túngara frog foam composition. The synthetic Túngara frog foam composition comprises six synthetically synthesized ranaspumin proteins (RSN-1 to RSN-6) wherein only the active segments of the RSN proteins are synthesized and six synthetically synthesized polysaccharides comprising four tetrasaccharides, a heptasaccharide and a nonasaccharide. Multiple novel applications of the foam are described.