Patents by Inventor Robert A. Shalwitz

Robert A. Shalwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prolyl hydroxylase inhibitors
    Patent number: 10562854
    Abstract: Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1?), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: February 18, 2020
    Assignee: AERPIO THERAPEUTICS, INC.
    Inventors: Joseph H. Gardner, Robert Shalwitz, Shengde Wu
  • TREATMENT OF OCULAR DISEASE
    Publication number: 20200010565
    Abstract: Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.
    Type: Application
    Filed: April 26, 2019
    Publication date: January 9, 2020
    Inventors: Kevin Peters, Robert Shalwitz
  • COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES
    Publication number: 20200009115
    Abstract: Disclosed are methods for the treatment of diseases or conditions of the eye, especially retinopathies, ocular edema and ocular neovascularization. Non-limiting examples of these diseases or conditions include diabetic macular edema, age-related macular degeneration (wet form), choroidal neovascularization, diabetic retinopathy, retinal vein occlusion (central or branch), ocular trauma, surgery induced edema, surgery induced neovascularization, cystoid macular edema, ocular ischemia, uveitis, and the like.
    Type: Application
    Filed: July 16, 2019
    Publication date: January 9, 2020
    Inventors: Kevin Gene PETERS, Robert Shalwitz
  • METHODS FOR THE USE OF 5'-ADENOSINE DIPHOSPHATE RIBOSE (ADPR)
    Publication number: 20190298752
    Abstract: The present invention is directed to methods for the use of 5?-adenosine diphosphate ribose (ADPR), and compositions thereof, for treating, managing, or preventing RNA virus-related diseases or conditions, herpes virus related diseases or conditions, Sirtuin 6 (Sirt6)-related diseases or conditions, Pax6 related diseases or conditions, and p53 related diseases or conditions.
    Type: Application
    Filed: March 26, 2019
    Publication date: October 3, 2019
    Applicant: Invirsa, Inc.
    Inventors: Robert Shalwitz, Anna Kotsakis Ruehlmann
  • METHODS OF TREATING DIABETIC NEPHROPATHY USING HPTPB INHIBITORS
    Publication number: 20190262321
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with diabetic nephropathy, for example, diabetic nephropathy resulting from hyperglycemia, kidney hyperfiltration, renal injury, glycation products, and cytokine activation.
    Type: Application
    Filed: February 25, 2019
    Publication date: August 29, 2019
    Inventors: Kevin PETERS, Mitchell BRIGELL, Stephen PAKOLA, Robert Shalwitz
  • COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20190231799
    Abstract: Disclosed herein are compositions and methods for treating ocular diseases, inter alia, diabetic macular edema, age-related macular degeneration (wet form), choroidal neovascularization, diabetic retinopathy, retinal vein occlusion (central or branch), ocular trauma, surgery induced edema, surgery induced neovascularization, cystoid macular edema, ocular ischemia, uveitis, and the like. These diseases or conditions are characterized by changes in the ocular vasculature whether progressive or non-progressive, whether a result of an acute disease or condition, or a chronic disease or condition.
    Type: Application
    Filed: January 25, 2019
    Publication date: August 1, 2019
    Inventors: Kevin Peters, Robert Shalwitz
  • Treatment of ocular disease
    Patent number: 10329357
    Abstract: Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: June 25, 2019
    Assignee: AERPIO THERAPEUTICS, INC.
    Inventors: Kevin Peters, Robert Shalwitz
  • METHODS FOR TREATING VASCULAR LEAK SYNDROME AND CANCER
    Publication number: 20190177409
    Abstract: Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, sepsis, cancer or the presence of pathogens.
    Type: Application
    Filed: October 23, 2018
    Publication date: June 13, 2019
    Inventors: Kevin Peters, Robert Shalwitz
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASASIS OF CANCER CELLS
    Publication number: 20190076405
    Abstract: Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.
    Type: Application
    Filed: March 6, 2018
    Publication date: March 14, 2019
    Inventors: Robert Shalwitz, Kevin Gene Peters
  • Compositions and methods for treating ocular diseases
    Patent number: 10220048
    Abstract: Disclosed herein are compositions and methods for treating ocular diseases, inter alia, diabetic macular edema, age-related macular degeneration (wet form), choroidal neovascularization, diabetic retinopathy, retinal vein occlusion (central or branch), ocular trauma, surgery induced edema, surgery induced neovascularization, cystoid macular edema, ocular ischemia, uveitis, and the like. These diseases or conditions are characterized by changes in the ocular vasculature whether progressive or non-progressive, whether a result of an acute disease or condition, or a chronic disease or condition.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: March 5, 2019
    Assignee: AERPIO THERAPEUTICS, INC.
    Inventors: Kevin Peters, Robert Shalwitz
  • PROLYL HYDROXYLASE INHIBITORS
    Publication number: 20190055198
    Abstract: Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1?), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 21, 2019
    Inventors: Joseph H. Gardner, Robert Shalwitz
  • Methods for treating vascular leak syndrome and cancer
    Patent number: 10150811
    Abstract: Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, sepsis, cancer or the presence of pathogens.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: December 11, 2018
    Assignee: AERPIO THERAPEUTICS, INC.
    Inventors: Kevin Peters, Robert Shalwitz
  • COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20180251457
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Application
    Filed: May 2, 2018
    Publication date: September 6, 2018
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20180237430
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20180237429
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
    Publication number: 20180237431
    Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Inventors: Kevin Peters, Robert Shalwitz, John Janusz, Alexander Smith
  • Compounds, compositions, and methods for preventing metastasis of cancer cells
    Patent number: 9949956
    Abstract: Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 24, 2018
    Assignee: Aerpio Therapeutics, Inc.
    Inventors: Robert Shalwitz, Kevin Gene Peters
  • PHOSPHATASE INHIBITORS FOR TREATING OCULAR DISEASES
    Publication number: 20180092883
    Abstract: Disclosed are compounds and pharmaceutical compositions effective for inhibition of HPTP-?. The compounds can provide effective therapy for ocular disease, for example, ocular edema and ocular neovascularization.
    Type: Application
    Filed: October 27, 2017
    Publication date: April 5, 2018
    Inventors: Kevin Gene Peters, Robert Shalwitz
  • TREATMENT OF OCULAR DISEASE
    Publication number: 20180044432
    Abstract: Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.
    Type: Application
    Filed: March 20, 2017
    Publication date: February 15, 2018
    Inventors: Kevin Peters, Robert Shalwitz
  • COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES
    Publication number: 20180037579
    Abstract: Disclosed are methods for the treatment of diseases or conditions of the eye, especially retinopathies, ocular edema and ocular neovascularization. Non-limiting examples of these diseases or conditions include diabetic macular edema, age-related macular degeneration (wet form), choroidal neovascularization, diabetic retinopathy, retinal vein occlusion (central or branch), ocular trauma, surgery induced edema, surgery induced neovascularization, cystoid macular edema, ocular ischemia, uveitis, and the like.
    Type: Application
    Filed: March 17, 2017
    Publication date: February 8, 2018
    Inventors: Kevin Gene Peters, Robert Shalwitz