Abstract: Provided herein are T-cell receptor (TCR) fusion proteins (TFPs), T-cells engineered to express one or more TFPs, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: A guide for cutting a cake into multiple layers. A pair of vertically positioned walls are joined adjacent their rear edges in a generally V-shape. The walls are slanted to taper upwardly from an integral base portion to an integral top and forming an open front. The front edges of the walls are provided with spaced horizontal slots extending inwardly from their front edges. The slots are approximately 0.0625 inch in width, between 1 inch and 11/2 inches in length, and approximately 1/2 inch apart. The slots in each wall are in horizontal alignment with each other whereby a knife blade can be inserted horizontally between pairs of slots to be held in a horizontal position at a predetermined level. A cake can be turned against the knife blade to slice a horizontal layer from the top portion of the cake. The blade can then be successively lowered from slot to slot to cut the cake into a plurality of 1/2 inch layers. The device may be stamped from metal or molded from a suitable plastic material.