Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: A wastewater treatment plant and related method comprise a treatment stage including a biological-process substage configured for growing unicellular organisms adapted to reduce contaminants in the wastewater which are dissolved, including at least one of organic matter and nitrogenous matter, by digestion thereof, and which are adapted to floc after digestion and a floc-removal substage downstream from the biological-process substage, relative to the flow of wastewater, and configured for substantially removing the unicellular organisms that have flocked. The treatment stage is configured to form majority and minority flows of treated wastewater, and the minority flow is configured to be recycled upstream of the biological-process treatment substage. The plant includes a heat transfer assembly configured for transferring heat from the majority flow of treated wastewater to the minority flow thereof to increase temperature of wastewater to be treated.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCR) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure generally relates to managing user profiles. An example method includes, at a computer system in communication with a display generation component and an input device: receiving, via the input device, a user input including a request to access a first restricted media item; and in response to the user input: in accordance with a determination the user input is a voice input and the voice input corresponds to a user profile authorized to access the first restricted media item using voice inputs, initiating playback of the first restricted media item; and in accordance with a determination the user input is a voice input and the voice input does not correspond to a user profile authorized to access the first restricted media item using voice inputs: forgoing initiating playback of the first restricted media item; and causing display, at the display generation component, of a validation user interface.

Abstract: A wastewater treatment plant and related method comprise a treatment stage including a biological-process substage configured for growing unicellular organisms adapted to reduce contaminants in the wastewater which are dissolved, including at least one of organic matter and nitrogenous matter, by digestion thereof, and which are adapted to floc after digestion and a floc-removal substage downstream from the biological-process substage, relative to the flow of wastewater, and configured for substantially removing the unicellular organisms that have flocked. The treatment stage is configured to form majority and minority flows of treated wastewater, and the minority flow is configured to be recycled upstream of the biological-process treatment substage. The plant includes a heat transfer assembly configured for transferring heat from the majority flow of treated wastewater to the minority flow thereof to increase temperature of wastewater to be treated.

Abstract: A water treatment plant and related method of water treatment comprise a treatment stage including a partial-treatment substage configured to apply at least one of chemical and physiochemical processes for reducing contaminants in the water, a preliminary filtration substage configured to remove large contaminants in the water such as microorganisms and pathogens, and a secondary filtration substage comprising one or more selectively permeable membranes configured to remove remaining contaminants which may include organic micro-organisms and ionic sized inorganic matter from the water. The plant also includes a heat transfer assembly configured to extract heat from water downstream of the treatment stage and to input the heat to water to be treated upstream of at least the secondary filtration substage, so as to recycle heat in the water within the plant to increase a treatment rate or reduce the power consumption of at least the secondary filtration substage.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCR) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: Methods and systems for providing a user-targeted report are provided. One method includes receiving an audio signal at a device, encoding a request for the report targeted to the requesting user. A set of incomplete tasks is identified, where tasks have a task-due timestamp and a reported status that indicates whether the task has been associated with a previous report. A set of upcoming tasks is identified from the incomplete tasks. A set of overdue tasks is identified from the incomplete tasks. From upcoming/overdue tasks a set of to-be-reported tasks is generated, via filtering criteria applied to the reported status of each task included in the upcoming/overdue tasks. The report includes a reminder for at least a portion of the tasks included in the set of to-be-reported tasks.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: A water purification device which can process contaminated water, and upgrade it to a potable quality or other secondary useful purposes such as irrigation, shower or laundry and general water. This is achieved without the use of chemicals or membranes. The device consists of a geometrical configuration of riser and connecting tubes for contacting ozone and ultraviolet (UV) light with said contaminated water in order to provide an advance oxidation environment, resulting in disinfection, a reduction in biological activity, chemical oxygen demand, organic species and other water-borne contaminants such as fungi, molds algae, bacteria, viruses, protozoa, oils, fats, tastes and odours. The geometrical configuration of contacting the ozone, UV and water, combined with an ozone injection system that results in optimum disinfection of the water.

Abstract: A beverage holding device comprising a container and a removably engageable lid. The container includes a partition extending between opposing sides of the sidewall of the container to define a plurality of separated cavities. The partition includes an edge surface forming an interior seal against a lower surface of the lid upon an engagement of the lid with the container for maintaining the plurality of cavities fluidly separated. A plurality of apertures in offset elevated positions above an upper surface of the lid are provided, with each communicating with a respective one of the plurality of cavities. The elevated and offset apertures provide a respective relief area to accommodate a projecting nose of a user during an engagement of the user's mouth with a respective aperture while tipping the container.

Abstract: A beverage holding device comprising a container and a removably engageable lid. The container includes a partition extending between opposing sides of the sidewall of the container to define a plurality of separated cavities. The partition includes an edge surface forming an interior seal against a lower surface of the lid upon an engagement of the lid with the container for maintaining the plurality of cavities fluidly separated. A plurality of apertures in offset elevated positions above an upper surface of the lid are provided, with each communicating with a respective one of the plurality of cavities. The elevated and offset apertures provide a respective relief area to accommodate a projecting nose of a user during an engagement of the user's mouth with a respective aperture while tipping the container.

Abstract: A beverage holding device comprising a container and a removably engageable lid. The container includes a partition extending between opposing sides of the sidewall of the container to define a plurality of separated cavities. The partition includes an edge surface forming an interior seal against a lower surface of the lid upon an engagement of the lid with the container for maintaining the plurality of cavities fluidly separated. A plurality of apertures in offset elevated positions above an upper surface of the lid are provided, with each communicating with a respective one of the plurality of cavities. The elevated and offset apertures provide a respective relief area to accommodate a projecting nose of a user during an engagement of the user's mouth with a respective aperture while tipping the container.

Abstract: A system and method for allowing market participants to evaluate the likelihood of finding hidden volume. The model can predict hidden volume and assess the probability that a market order will be executed within the spread and better than the mid-quote. The cost per immediate execution can be assessed.

Abstract: A leak detection device (10) comprising a first membrane (12), the first membrane (12) containing at least one indicator chemical (16) responsive to anaerobic conditions, wherein the first membrane (12) is at least in part semi-permeable such that it allows passage of oxygen therethrough substantially in only one direction.

Abstract: A system and method for allowing market participants to evaluate the likelihood of finding hidden volume. The model can predict hidden volume and assess the probability that a market order will be executed within the spread and better than the mid-quote. The cost per immediate execution can be assessed.