Patents by Inventor Robert A. Slater

Robert A. Slater has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biologically active compounds
    Patent number: 4997847
    Abstract: The invention relates to phenylsulphonamidolkanoic acids which have thromboxane A.sub.2 receptor antagonist activity.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: March 5, 1991
    Assignees: Smith Kline & French Laboratories Limited, Boehringer Mannheim GmbH
    Inventors: Robert J. Ife, David G. Cooper, Robert A. Slater, Karlheinz Stegmeier, Ernst-Christian Witte
  • Substituted sulphonamides, pharmaceuticals thereof and methods of using them
    Patent number: 4981873
    Abstract: The present invention concerns compounds of the formula: ##STR1## where R.sub.1 is an alkyl or alkenyl radical containing up to 6 carbon atoms, a cycloalkyl radical containing 3 to 7 carbon atoms, an aralkyl, aralkenyl or aryl radical in which the aryl radical or moiety can be substituted one or more times by halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, hydroxyl, trifluoromethyl, cyano, nitro, amino, C.sub.1 -C.sub.6 -alkylamino, C.sub.2 -C.sub.12 -dialkylamino, C.sub.1 -C.sub.6 -acylamino, C.sub.1 -C.sub.16 -acyl, C.sub.1 -C.sub.6 -alkylsulphenyl, -sulphinyl or -sulphonyl or by azido, R.sub.2 is hydrogen atom or a C.sub.1 -C.sub.6 -alkyl, aralkyl, aralkenyl or acyl radical, A and B are saturated or unsaturated alkylene chains containing up to 10 carbon atoms which can be substituted one or more times by C.sub.1 -C.sub.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: January 1, 1991
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ernst-Christian Witte, Karlheinz Stegmeier, Liesel Doerge, Robert A. Slater
  • Novel guanidino pyridazinones as cardiac stimulants
    Patent number: 4946842
    Abstract: The invention relates to phenyl dihydropyridazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.3 -benzyl-N.sup.2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: August 7, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, John C. Emmett, Robert A. Slater
  • 5-phenyl-3[2H]-pyridazinone derivatives
    Patent number: 4820819
    Abstract: This invention relates to (isopropyl and tertiary butyl-amino-2-hydroxypropoxy)phenyl-3[2H]-pyridazinones which have .beta.-adrenoceptor antagonist activity.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: April 11, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Anthony M. Roe, William J. Coates, Robert A. Slater, Stephen P. Breukelman
  • Pharmaceutically active compounds
    Patent number: 4812573
    Abstract: The invention relates to a class of tetrahydroisoquinolinylalkanoic acids containing an aryl sulphonamide group which have activity as thromboxane A.sub.2 antagonists.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: March 14, 1989
    Assignee: SmithKline & French Laboratories, Ltd.
    Inventors: Graham J. Durant, Andrew D. Gribble, Robert A. Slater
  • Pharmaceutical compositions having .beta.-adrenoceptor antagonist activity employing pyridazinone derivatives
    Patent number: 4678786
    Abstract: This invention relates to (isopropyl and tertiary butyl-amino-2-hydroxypropoxy)phenyl-3[2H]-pyridazinones which have .beta.-adrenoceptor antagonist activity.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: July 7, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Anthony M. Roe, William J. Coates, Robert A. Slater, Stephen P. Breukelman, George D. Meakins
  • Heterocyclic compounds having inotropic activity
    Patent number: 4657906
    Abstract: This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by an amino or acylamino group. These compounds has inotropic activity. One specific compound is 5-(4-acetamidophenyl)-2(1H)-pyrazinone.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: April 14, 1987
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: John C. Emmett, Robert A. Slater, Brian H. Warrington
  • 6-(cyanoguanidinophenyl)pyridazinones as cardiac stimulants
    Patent number: 4654342
    Abstract: This invention relates to cyanoguanidine derivatives that have utility in the treatment of congestive heart failure. A specific compound of this invention is 6-[4-(N.sup.3 -methyl-N.sup.2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: March 31, 1987
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventor: Robert A. Slater
  • Vasodilators and .beta.-adrenoceptor antagonists
    Patent number: 4652563
    Abstract: This invention relates to dihydropyridazinone compounds having a cyclopropylmethoxyethyl group in the 6-substituent. These compounds are vasodilators and .beta.-adrenoceptor antagonists. A particular compound of the invention is 6-[4-[3-[2-hydroxy-3-[4-(2-(cyclopropylmethoxy) ethyl)phenoxy]propylamino]propionamido]phenyl]-5-methyl-4,5-dihydro-3 (2H)-pyridazinone.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: March 24, 1987
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventor: Robert A. Slater
  • 5-(4-substituted)phenyl-2-pyrazinones
    Patent number: 4632924
    Abstract: This invention relates to 5-(4-substituted)phenylpyrazinone compounds which have positive inotropic and vasodilator activity. One such compound is 5-(4-carboxamidophenyl)pyrazin-2(1H)-one.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: December 30, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: John C. Emmett, Robert A. Slater
  • 5-(4-Amino or acylaminophenyl)-2(1H)-pyrazinones having inotropic activity
    Patent number: 4556711
    Abstract: This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by an amino or acylamino group. These compounds have inotropic activity. One specific compound is 5-(4-acetamidophenyl)-2(1H)-pyrazinone.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: December 3, 1985
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: John C. Emmett, Robert A. Slater, Brian H. Warrington