Patents by Inventor Robert A. Stavenger

Robert A. Stavenger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazolo-tetrahydropyrimidine-carboxamide derivative kinase inhibitors
    Patent number: 7560467
    Abstract: The present invention relates to indazolo-tetrahydropyrimidine-carboxamide derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such indazolo-tetrahydropyrimidine-carboxamide derivatives are useful in the treatment of diseases associated with inappropriate ROCK-1 kinase.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: July 14, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: David Harold Drewry, Brian Evans, Krista B. Goodman, Darren Victor Steven Green, David Kendall Jung, Dennis Lee, Robert A. Stavenger, Sjoerd Nocolaas Wadman
  • Preparation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
    Patent number: 7547779
    Abstract: Novel inhibitors of Rho-kinases are disclosed.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: June 16, 2009
    Assignee: Glaxo Group Limited
    Inventors: Dennis Lee, Robert A. Stavenger, Krista B. Goodman, Mark A. Hilfiker, Haifeng Cui, Andrew Q. Viet, Joseph P. Marino
  • Chemical Compounds
    Publication number: 20080293716
    Abstract: There is provided a compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof:
    Type: Application
    Filed: January 28, 2005
    Publication date: November 27, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: David Harold Drewry, Robert Neil Hunter, III, David Kendall Jung, James Andrew Linn, Clark Sehon, Robert A. Stavenger
  • Chemical Compounds
    Publication number: 20080275062
    Abstract: There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy, C1-4alkoxycarbonyl, C1-4alkylsulfonyl and a group R3R4NSO2 (wherein R3 and R4 are independently hydrogen or C1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consistin
    Type: Application
    Filed: January 28, 2005
    Publication date: November 6, 2008
    Inventors: David Harold Drewry, David Kendall Jung, James Andrew Linn, Robert Neil Hunter, Dennis Lee, Robert A. Stavenger, Clark Sehon
  • Preparation of 1,6-Disubstituted Azabenzimidazoles as Kinase Inhibitors
    Publication number: 20080234261
    Abstract: Novel inhibitors of Rho-kinases are disclosed.
    Type: Application
    Filed: October 6, 2004
    Publication date: September 25, 2008
    Inventors: Dennis Lee, Robert A. Stavenger, Krista A. Goodman, Mark A. Hilfiker, Haifeng Cui, Andrew Q. Viet, Joseph P. Marino
  • Compounds and methods
    Patent number: 7365085
    Abstract: Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: April 29, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Ajita Bhat, John Jeffrey McAtee, Scott K. Thompson, James S. Frazee, Lara S. Kallander, Chun Ma, Joseph Marino, Michael J. Neeb, Robert A. Stavenger
  • Imidazopyridine derivatives as kinase inhibitors
    Patent number: 7348339
    Abstract: A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: March 25, 2008
    Assignee: Glaxo Group Limited
    Inventors: Nicholas Bailey, Mark James Bamford, Haifeng Cui, Stephen Garland, Krista B Goodman, Mark A Hilfiker, Dennis Lee, Terence Aaron Panchal, Robert A Stavenger, David Matthew Wilson, Jason Witherington
  • Dihydropyrancarboxamides and uses thereof
    Publication number: 20080070916
    Abstract: The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R1-R6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.
    Type: Application
    Filed: March 6, 2007
    Publication date: March 20, 2008
    Inventors: Stuart Schreiber, Robert Stavenger, Timothy Mitchison, Zoltan Maliga
  • Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors
    Publication number: 20070123561
    Abstract: Novel inhibitors of Rho-kinases are disclosed.
    Type: Application
    Filed: October 6, 2004
    Publication date: May 31, 2007
    Inventors: Dennis Lee, Robert Stavenger, Krista Goodman, Mark Hilfiker, Haifeng Cui, Joseph Marino
  • Dihydropyrancarboxamides and uses thereof
    Patent number: 7186709
    Abstract: The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R1–R6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: March 6, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Robert A. Stavenger, Timothy J. Mitchison, Zoltan Maliga
  • Imidazopyridine derivatives as kinase inhibitors
    Publication number: 20050197328
    Abstract: A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.
    Type: Application
    Filed: March 21, 2003
    Publication date: September 8, 2005
    Inventors: Nicholas Bailey, Mark Bamford, Haifeng Cui, Stephen Garland, Krista Goodman, Mark Hilfiker, Dennis Lee, Terence Panchal, Robert Stavenger, David Wilson, Jason Witherington
  • Dihydropyrancarboxamides and uses thereof
    Publication number: 20040059138
    Abstract: The present invention provides novel dihydropyrancarboxamide compounds of formula (I): 1
    Type: Application
    Filed: August 27, 2003
    Publication date: March 25, 2004
    Inventors: Stuart L. Schreiber, Robert A. Stavenger, Timothy J. Mitchison, Zoltan Maliga