Abstract: Various systems and methods relate to an adaptive chair system having (i) a stowed mode in which the members of the chair frame are contained within a compact flexible multi-function bag (MFB), and (ii) a deployed mode in which the MFB is adapted to releasably couple to an arm of the chair to provide a multipurpose accessory chamber. In an illustrative example, the MFB may, for example, fold in on itself in an accessory mode. The MFB may provide various utilities for hikers, for example, by providing a case to receive an inflatable bladder so as to form a pillow. The MFB may receive a thermal liner adapted to maintain, for example, food or beverage temperature. Various embodiments may advantageously provide a rugged, water resistant MFB system in an ultralight form factor that serves as a multipurpose accessory (e.g., to store items), yet provides a compact, adaptive chair frame containment.

Abstract: A biosensor includes an optical circuit that obtains a plurality of photoplethysmography (PPG) signals from light at different wavelengths that is reflected from or transmitted through tissue of a user. A processing circuit determines a measurement value for a nitric oxide (NO) level in blood flow using first and second PPG signals and determines an insulin response from caloric intake using the measurement value for the NO level in blood flow. The first PPG signal is obtained from light at a wavelength having a high absorption coefficient for NO in blood flow and the second PPG signal is obtained from light at a second wavelength having a low absorption coefficient for NO in blood flow. The processing circuit also determines one or more phases of digestion using at least one or more of the plurality of PPG signals.

Abstract: The invention relates to methods of treating COVID-19 in a patient by administering therapeutically effective amounts of certain SARS-CoV-2 inhibitor compounds or pharmaceutical compositions containing them to a patient in need thereof.

Abstract: A radio frequency (RF) coil assembly for a magnetic resonance (MR) system is provided. The RF coil assembly includes an RF coil array and a substrate assembly. The RF coil array includes one or more RF coils each RF coil including a coil loop that includes a wire conductor, the wire conductor formed into the coil loop. The substrate assembly includes a first substrate layer and a second substrate layer, wherein the first substrate layer is coupled with the second substrate layer at seams without a separately-provided fastening mechanism, wherein the RF coil array is positioned between the first substrate layer and the second substrate layer.

Abstract: Systems and methods for moving a vehicle component relative to the vehicle, the system including first and second upwardly-extending supports; a lift frame between the first and second supports including a crossbeam, and a pair of cambered truss assemblies secured to the crossbeam and configured to be attached to the vehicle component; movable first and second crossbeam support assemblies on the first and second supports to support the rotation of the crossbeam; a first lift mechanism configured to move the first crossbeam support assembly along the first support in response to a first control signal; a rotational drive mechanism configured to rotate the crossbeam relative to the first and second crossbeam support assemblies in response to a second control signal; and an electronic controller configured to generate the first and second control signals to change the position of the vehicle component relative to the vehicle.

Abstract: The invention relates to compounds of formula I wherein R1 and R2 are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compound

Abstract: The automated package delivery receptacle provides a faster, easier, more delivery-person friendly, and more reliable method of ensuring that packages delivered to unattended locations are not stolen by porch pirates. The receptacle automatically detects any package that is placed on top of it. As soon as the person who delivered the package has departed, the top surface lifts up above the body of the receptacle, rotates to a vertical position, and drops the package into the interior compartment. The top then reverses its motion and returns to its resting horizontal position, locked and ready for another delivery. The receptacle's mechanism does not encroach at all on the receptable's interior compartment space while cycling. It is powered by a 12-volt automobile type battery connected to a motor controller that is programmed to drive a high-speed linear actuator to complete its open/close cycle in less than twenty seconds.

Abstract: The present invention provides a cannulation device for administering an active agent containing composition to the suprachoroidal space or supraciliary space. The invention provides methods of treatment of an ocular disease or condition accordingly. The invention also provides compositions for use in a method of treatment of an ocular disease or condition for delivery into the suprachoroidal space or supraciliary space.

Abstract: The invention relates to methods of treating COVID-19 in a patient by administering therapeutically effective amounts of certain SARS-CoV-2 inhibitor compounds or pharmaceutical compositions containing them to a patient in need thereof. The invention also relates to inhibiting SARS-CoV-2 coronavirus viral replication activity comprising contacting SARS-CoV-2-related coronavirus protease with a therapeutically effective amount of a SARS-Cov-2 protease inhibitor, such as a SARS-Cov-2 3CL protease inhibitor and compositions comprising the same.

Abstract: Medical imaging devices, systems, and methods thereof. The medical imaging system may include a movable station and a gantry. The movable station includes a gantry mount rotatably attached to the gantry. The gantry includes an outer C-arm slidably mounted to and operable to slide relative to the gantry mount, an inner C-arm slidably coupled to the outer C-arm and, an imaging signal transmitter and sensor attached to the C-arms. The two C-arms work together to provide a full 360 degree rotation of the imaging signal transmitter. In embodiment, the imaging signal transmitter and imaging sensor are offset from a center axis of the medical imaging system such that the portable medical imaging system is operable to capture an enlarged field of view.

Abstract: A recreational vehicle waste disposal system is provided. The waste disposal system includes a conduit assembly having a proximal end connected to the sewer outlet of a sanitation unit, wherein the distal end of the waste disposal system is rotatable relative to and extendable from the proximal end. A user may rotate the conduit assembly between an operable position and a stored position directly under the RV's sanitation unit. The downstream portion defines an extension arrangement of a plurality of threaded conduit sections that may be optionally connected to allow an extended length to store two waste hoses if desired.

Abstract: Digital or analog samples are sent from a video source to a video storage subsystem that encodes the samples into analog levels, stores the analog levels for a period of time, decodes the analog levels back into digital samples and then sends the digital samples to a video sink for display, N samples are encoded into L analog levels for storage. The storage subsystem may be located at the video source, at the video sink, or anywhere in between the two. The storage subsystem may be located on an electromagnetic pathway over which the L encoded analog levels are transmitted from a video source as an analog signal. The L encoded analog levels are written to storage and then later read from storage and retransmitted over the electromagnetic pathway toward a video sink. The storage subsystem may also be integrated with a transmitter that encodes the samples into analog levels for storage or may be integrated with a receiver that stores the analog levels and then decodes the analog levels back into samples.

Abstract: The disclosure pertains to a recombinant adeno-associated virus (rAAV) comprising an Anc80L65 capsid for delivering a polynucleotide (e.g., a transgene) into the central nervous system (CNS). Further provided includes methods for treating CNS diseases using the rAAV and pharmaceutical compositions comprising the rAAV.

Abstract: Various methods and systems are provided for a flexible, lightweight and low-cost stretchable radio frequency (RF) coil of a magnetic resonance imaging (MRI) system. In one example, a RF coil assembly for a MRI system includes a loop portion comprising distributed capacitance conductor wires, a coupling electronics portion including a pre-amplifier; and a stretchable material to which the loop portion and coupling electronics portion are attached and/or enclosed therein.

Abstract: The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.

Abstract: A video display hub is mounted in a common household area such as a kitchen or family room. The display hub is configured to display various types of information for users in the area, such as weather, traffic updates, schedules, notes, messages, lists, news, etc. When the user is at a distance from the display hub, information is presented at a relatively low density, with a low level of granularity and detail in conjunction with large fonts, graphics, and icons. When the user is close to the display hub, information is presented at a relatively high density, with a high level of granularity and detail in conjunction with small fonts, graphics, and icons.

Abstract: This invention relates to compounds of general Formula I and pharmaceutically acceptable salts thereof, in which R1, R2, R3a, R3b, and R4 are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: Positioning system and method for positioning engine components on an aircraft, the system including a moveable support for the engine component, a laser assembly, and a system controller. First and second lasers of the laser assembly align their respective beams with an engine target position on the aircraft and provide an indication of a first angle of the first laser beam to a reference line, and an indication of a second angle of the second laser beam to the reference line; and the system controller is configured to rotate the moveable support to rotationally position the engine component, determine the vertical distance between the engine component and the target position based at least in part on the first and second angles, and to control a lift mechanism to reduce the vertical distance between the engine component and the engine.

Abstract: Medical imaging devices, systems, and methods thereof. The medical imaging system may include a movable station and a gantry. The movable station includes a gantry mount rotatably attached to the gantry. The gantry includes an outer C-arm slidably mounted to and operable to slide relative to the gantry mount, an inner C-arm slidably coupled to the outer C-arm and, an imaging signal transmitter and sensor attached to the C-arms. The two C-arms work together to provide a full 360 degree rotation of the imaging signal transmitter. In embodiment, the imaging signal transmitter and imaging sensor are offset from a center axis of the medical imaging system such that the portable medical imaging system is operable to capture an enlarged field of view.

Abstract: A supine torso radio frequency (RF) coil assembly for a magnetic resonance (MR) system is provided. The RF coil assembly includes an RF coil array and a lining. The RF coil array includes a plurality of RF coils each RF coil including a coil loop that includes a wire conductor, the wire conductor formed into the coil loop and a coupling electronics portion coupled to the coil loop. The plurality of RF coils form into a contoured portion, the contoured portion sized to receive at least part of a breast of a subject therein. The lining includes a contoured portion. The RF coil array is coupled to and distributed on the lining, the contoured portion of the RF coil array covering and conforming with the contoured portion of the lining.