Abstract: The present invention provides an apparatus for detecting presence or otherwise of an item comprising at least two regions having different optical characteristics, said apparatus comprising: an emitter operative to illuminate a measuring region of said apparatus with electromagnetic radiation; and a detector located and operative to receive electromagnetic radiation reflected from said measuring region of said apparatus and operative to output a signal corresponding to a measured characteristic of said electromagnetic radiation reflected from said measuring region, wherein said apparatus is operative to compare said measured characteristic with a set of pre-defined characteristics, and further wherein if said measured characteristic is consistent with at least one of said pre-defined characteristics, the apparatus is operative to output a signal indicative of presence or otherwise of one of said at least two regions of said item in said measuring region.

Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.

Abstract: Systems and methods for animal health monitoring are described. In one embodiment, an animal health monitoring system includes a ruminant bolus transponder, a high frequency radio frequency transceiver device, and at least one base station including a high frequency radio frequency transceiver, wherein the high frequency radio frequency transceiver device is proximally located to the bolus transponder, wherein the ruminant bolus periodically emerges from a low power dormant state and measures data including at least one sensor measurement including time and date data, wherein the ruminant bolus is configured to store the measured data using the memory connected to the microcontroller in the ruminant bolus, wherein the ruminant bolus periodically emerges from a low power dormant state and transmits the stored data in the memory to the proximally located device via high frequency RF transmission, and wherein the ruminant bolus can be spontaneously activated by a low frequency scanner.

Abstract: A retention clip assembly is for attachment to a stud. The assembly includes a base plate and a cover plate. The base plate includes a base rim and a locking finger extending from the base rim. The cover plate includes a cover rim and a flange. The cover rim defines a lock opening configured for receiving the locking finger therein to retain the cover plate to the base plate. The flange extends inwardly from the cover rim at an angle which is acute such that the flange overlays the cover opening and is configured for engaging the external teeth on the stud. The cover plate attached to the base plate with a sheet of material therebetween. The cover plate and base plate are positioned such that the flange engages the external teeth of the stud to prevent removal of the retention clip assembly from the stud.

Abstract: This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.

Abstract: Systems and methods for animal health monitoring are described. In one embodiment, an animal health monitoring system includes a ruminant bolus transponder, a high frequency radio frequency transceiver device, and at least one base station including a high frequency radio frequency transceiver, wherein the high frequency radio frequency transceiver device is proximally located to the bolus transponder, wherein the ruminant bolus periodically emerges from a low power dormant state and measures data including at least one sensor measurement including time and date data, wherein the ruminant bolus is configured to store the measured data using the memory connected to the microcontroller in the ruminant bolus, wherein the ruminant bolus periodically emerges from a low power dormant state and transmits the stored data in the memory to the proximally located device via high frequency RF transmission, and wherein the ruminant bolus can be spontaneously activated by a low frequency scanner.

Abstract: In an inductively coupled radio frequency identification (RFID) system deployed in animal and livestock applications, reading system efficacy can be compromised by animal movement on, around, or near metal structures prone to producing sonic frequencies. Such is the case, for example, when a walk-by antenna is mounted at the entry door of a livestock transport trader, and animals transit on a metallic ramp and metallic trader floor. Associated with the observable acoustic noise are subtle disturbances in the magnetic field surrounding the antenna due to vibrating metal altering the reluctance of the antenna's magnetic field. This acoustic noise manifests itself as an electrical noise phenomenon that interferes with the signals of certain types of identification tags which rely on amplitude modulation.

Abstract: There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.

Abstract: A retention clip assembly is for attachment to a stud. The assembly includes a base plate and a cover plate. The base plate includes a base rim and a locking finger extending from the base rim. The cover plate includes a cover rim and a flange. The cover rim defines a lock opening configured for receiving the locking finger therein to retain the cover plate to the base plate. The flange extends inwardly from the cover rim at an angle which is acute such that the flange overlays the cover opening and is configured for engaging the external teeth on the stud. The cover plate attached to the base plate with a sheet of material therebetween. The cover plate and base plate are positioned such that the flange engages the external teeth of the stud to prevent removal of the retention clip assembly from the stud.

Abstract: There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.

Abstract: A slat for use in an agricultural harvester including a web securable to a material moving system. A first and second leg extending outwardly from one side of the web, the first leg providing primary impetus for movement of crop material in a first direction by the material moving system. A third leg extending outwardly from an opposed side of the web and providing secondary impetus for movement of crop material by driven movement of the material moving system. In response to the slat encountering a foreign object that becomes wedged between the first leg, the third leg and structure of the material moving system and preventing driven movement of the material movement system in the first direction, upon application of force urging movement of the material movement system in an opposed second direction, the third leg facilitating a rotational movement of the slat for dislodging the foreign object.

Abstract: A slat for use in an agricultural harvester including a web securable to a material moving system. A first and second leg extending outwardly from one side of the web, the first leg providing primary impetus for movement of crop material in a first direction by the material moving system. A third leg extending outwardly from an opposed side of the web and providing secondary impetus for movement of crop material by driven movement of the material moving system. In response to the slat encountering a foreign object that becomes wedged between the first leg, the third leg and structure of the material moving system and preventing driven movement of the material movement system in the first direction, upon application of force urging movement of the material movement system in an opposed second direction, the third leg facilitating a rotational movement of the slat for dislodging the foreign object.

Abstract: Transponders are disclosed that are configurable to operate in an HDX mode and/or an FDX-B mode and that use a switchable load impedance across the transponders' resonant antenna circuit to induce amplitude and/or frequency modulation. One embodiment of the invention includes an inductive antenna including two terminals connected to tag circuitry, where the inductive antenna forms a resonant antenna circuit tuned to resonate at the frequency of the activation signal. The tag circuitry and the resonant antenna circuitry are configurable as an oscillator, the tag circuitry is configured to be powered by electric current induced in the resonant antenna circuit, includes at least one switchable load impedance connected across the antenna resonant circuit, configured to amplitude modulate the activation signal appearing at the resonant antenna circuit terminals using a switchable load impedance, and to frequency shift key modulate the oscillator signal appearing at the resonant antenna circuit terminals.

Abstract: A camsylate salt of (1r,1?R,4R)-4-methoxy-5?-methyl-6?-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3?H-dispiro[cyclohexane-1,2?-inden-1?2?-imidazole]-4?-amine, pharmaceutical compositions containing the salt and therapeutic uses of the salt for treating A?-related pathologies such as Alzheimer's Disease, Down's syndrome, ?-amyloid angiopathy and conditions such as dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

Abstract: A combine feeding system includes a lower conveyor roller configured to rotate around a lower conveyor roller axis, an upper conveyor roller configured to rotate around an upper conveyor roller axis and a drive shaft configured to rotate around a drive shaft axis. The lower conveyor roller axis, upper conveyor roller axis and drive shaft axis are substantially perpendicular to first and second housing walls. The feeding system also includes at least one chain configured to move over the drive shaft, the lower conveyor roller and the upper conveyor roller. The feeding system further includes at least one lower support arm coupled to the drive shaft and the lower conveyor roller and configured to pivot about the drive shaft axis. At least one force mechanism is configured to apply a force to the at least one chain in at least one of a first direction and a second direction.

Abstract: Transponders are disclosed that are configurable to operate in an HDX mode and/or an FDX-B mode and that use a switchable load impedance across the transponders' resonant antenna circuit to induce amplitude and/or frequency modulation. An RF level detection circuit determines when the instantaneous activation signal strength is sufficient to support monoplex, multiplex, and diplex operation. A non-volatile memory stores identification data coded in HDX and FDX-B formats. One embodiment of the invention includes an inductive antenna including two terminals connected to tag circuitry, where the inductive antenna forms a resonant antenna circuit tuned to resonate at the frequency of the activation signal.

Abstract: A pin assembly for a chain of a material moving system includes a pin having a first end and a second end, the first end having a threaded portion extending to a guide region having a reduced cross-section compared to the threaded portion, the threaded portion being at least partially modified during fabrication of the pin, the guide region extending to a transition region of increasing cross-section with respect to the guide region from the first end toward the second end, the transition region terminating at a shoulder. A fastener is configured to engage the threaded portion during construction of the chain. During construction of the chain, the pin and the fastener form a compression fit therebetween in response to a predetermined torque applied to the fastener, damaging at least a segment of the fastener, substantially limiting reuse of the fastener after the fastener has been disassembled from the pin.

Abstract: A pin assembly for a chain of a material moving system includes a pin having a first end and a second end, the first end having a threaded portion extending to a guide region having a reduced cross-section compared to the threaded portion, the threaded portion being at least partially modified during fabrication of the pin, the guide region extending to a transition region of increasing cross-section with respect to the guide region from the first end toward the second end, the transition region terminating at a shoulder. A fastener is configured to engage the threaded portion during construction of the chain. During construction of the chain, the pin and the fastener form a compression fit therebetween in response to a predetermined torque applied to the fastener, damaging at least a segment of the fastener, substantially limiting reuse of the fastener after the fastener has been disassembled from the pin.