Patents by Inventor Robert A. Strelitz

Robert A. Strelitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4579849
    Abstract: Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R.sup.1 and R.sup.2 are independently alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, each having 1 to 19 carbon atoms, or R.sup.2 is hydrogen; R.sup.3 is hydrogen, alkyl having 1 to 6 carbon atoms or hydroxyalkyl having 1 to 6 carbon atoms; R.sup.4 is hydrogen, halogen, amino or alkyl having 1 to 4 carbon atoms; R.sup.5, R.sup.6 and R.sup.7 are independently selected from hydrogen, hydroxy, alkyl having 1 to 6 carbon atoms, acyloxy having 1 to 8 carbon atoms, alkoxy having 1 to 6 carbon atoms, hydroxyalkyl having 1 to 6 carbon atoms, acyloxyalkyl having 1 to 12 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms and --PO.sub.3.sup.=, or two of R.sup.5, R.sup.6 and R.sup.7 taken together form a group --OPO.sub.2 O.sup.- --, --CH.sub.2 OPO.sub.2 O.sup.- --, --CH.sub.2 OPO.sub.2 OPO.sub.2 O.sup.= --, or --OPO.sub.2 OPO.sub.2 O.sup.= --; A is O, S or CH.sub.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: April 1, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Malcolm MacCoss, Richard L. Tolman, Robert A. Strelitz
  • Patent number: 4139559
    Abstract: A process for preparing 1-[1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentyl]-1,5,9-triazanonane from 1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentanone by reaction with ammonia to form, after reduction, 3-amino-[1,5-di-(3,3-dimethylnorborn-2-yl)pentane]. This latter compound is reacted with acrylonitrile, reduced, and the diamine product again reacted with acrylonitrile and again reduced. Alternative routes wherein the ketone is reduced to the novel alcohol and optionally the novel halide and either then reacted with 3,3'-iminobispropylamine to form the desired polyamine are also shown.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: February 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4100193
    Abstract: Novel dibicyclo [2.2.2] octyl dibicyclo [2.2.2] octenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: June 10, 1976
    Date of Patent: July 11, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4081534
    Abstract: A method and composition of treating a mammal suffering from an autoimmune disease which comprises internally administering to the mammal an effective autoimmune suppressant amount of the compound of formula or its pharmaceutically acceptable salts ##STR1## where R.sup.1 is amino or lower alkylamino and R.sup.2 is amino or hydrogen, provided that when R.sup.1 is amino, R.sup.2 is amino.
    Type: Grant
    Filed: July 26, 1976
    Date of Patent: March 28, 1978
    Assignee: Burroughs Wellcome Co.
    Inventors: Gertrude B. Elion, Robert A. Strelitz
  • Patent number: 4065497
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4049417
    Abstract: Novel dicyclohexyl, dicyclohexenyl and cyclohexylcyclohexenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: September 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Bruce E. Witzel, Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4049559
    Abstract: An antimicrobial composition for secondary and tertiary oil recovery comprising a flooding composition consisting of displacement and driving fluids having incorporated therein an antimicrobially effective amount of a di-bicyclo[3.1.1] or [2.2.1] heptyl or di-bicyclo[3.1.1] and [2.2.1] heptenyl polyamines or salts thereof.
    Type: Grant
    Filed: May 18, 1976
    Date of Patent: September 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4038479
    Abstract: Compounds of the formula ##STR1## where R.sup.1 is amino or lower alkylamino, R.sup.2 is amine or hydrogen and pharmaceutically acceptable salts thereof, provided that when R.sup.1 is amino, R.sup.2 is amino. The compounds are useful as immune suppressants and as antivirals.
    Type: Grant
    Filed: September 7, 1971
    Date of Patent: July 26, 1977
    Assignee: Burroughs Wellcome Co.
    Inventors: Gertrude B. Elion, Robert A. Strelitz
  • Patent number: 4035174
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a cyclohexylene group in the polyamine moiety are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial waters where microbial control is desired.
    Type: Grant
    Filed: March 26, 1976
    Date of Patent: July 12, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4033748
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: July 2, 1976
    Date of Patent: July 5, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz