Abstract: A new type of secondary locking system for article carriers consisting of at least one secondary male lock with two shoulders that is attached by a neck to the edge of a outer flap on the carrier for use with a primary locking system. An inner flap has a secondary female opening for each secondary male lock. The secondary female opening is formed by a secondary cut line and fold line with the center of the fold line projecting towards the edge of the flap while of the center of the secondary cut line projects away from the edge of the flap to guide the secondary male lock into a flat position against the inside of the inner flap. The shoulders on the secondary male lock are engaged against locking ledges along the extensions of the secondary cut line. A pair of slits may be formed at the end of the fold lines that project inwardly to allow the secondary male lock to slide into a flat position.

Abstract: A carton with bevel corners for carrying cans, or other articles, which has an interlocking separator pad so the cans or articles can be contained in two layers is provided. The carton has two ends, each of which is closed by two side end closures and top and bottom end flaps. Each side end closure has an aperture that is interlocked with the end portion of an interlocking separator pad. In one embodiment of this invention, the interlocking separator pad has two tabs with the aperture in each side end closure being a slot through which a tab is extended. This pad may have a foldably attached leading flap that is lodged between cans or articles contained in the carton and the side end closures.

Abstract: A carton is provided for carrying articles or containers in two layers with three rows of containers in each layer. The carton can have a dispenser flap in one side panel which can be opened for dispensing containers when the carton is placed on the end adjacent to the dispenser opening. The two layers of containers are kept separate during the dispensing by an interlocking separator pad that is interlocked to the side end flaps on one end of the carton by punch locks going through the primary female openings of the leading flap attached to the separator pad. A secondary locking system is provided by a swing lock in each side end flap on the interlocking end of the carton which has a secondary male lock attached to it that is inserted into a secondary female opening in the separator pad. Each secondary male lock may have a locking slot that engages a locking edge of the secondary female opening.

Abstract: A carton for carrying containers, such as cans, or other articles in two layers which has an interlocking separator pad between the two layers is provided. This separator pad has two tabs on each end which extend through slots provided on the side end flaps on each end of the carton to hold the separator pad in proper position between two layers of articles or containers. The pad has a leading flap that is folded up or down on one end of the carton between the articles or containers and the side end flaps to assist in holding the separator pad in proper position during the removal of containers from the carton through a dispenser opening formed in the carton. Preferably, the separator pad has a leading flap on both ends to assist in holding the separator pad in proper position. This carton may be provided with a dispenser in the side panel near the end on which the carton is rested to dispense cans.

Abstract: A carton with a new type of dispenser that is placed midway between the ends of the carton adjacent a fold line between the top panel and adjoining side panel. The dispenser is designed so that it is slightly larger than the diameter of the bottom ends of from two to three containers. Said dispenser may have a push tab or starting flap to aid in commencing tearing the dispenser flap open. A coupon may be located on the inside or outside of the dispenser flap.

Abstract: A wrap around carrier for carrying bottle with a petaloid base having heel assemblies that have hinge doors with a vertical cut line in the bottom of each hinge with a horizontal cut line at the top of each cut line that extends inwardly towards the heel aperture formed by the door. This carton has a second cut line that is either at the bottom of the vertical cut line in each hinge or near the center of the door. None of these cut lines extend into the heel aperture. This combination of cut lines facilitates the control tearing of the cut line at the top of the vertical cut line into the heel aperture.

Abstract: An enclosed carton for carrying a number of containers, such as cans, which is easily convertible into a tray with a lid, from which the cans can be easily removed. The tray is formed by a zipper with two tear lines that are formed in the adjoining bottom flaps of the carton. The carton may have a carrying handle for carrying the carton loaded with containers. This carton is especially designed to be easily convertible into a tray for holding cans between two closely spaced shelves in a refrigerator. Provision is made for the easy removal of the lid. Another embodiment of this invention discloses an enclosed carton with diamond shaped corners so that the carton can be tightly packed and which is also convertible into a tray.

Abstract: An apparatus and method of localization of a sensor device and/or anatomical landmark within a body. The sensor device may have multiple imagable marker properties to discern its orientation in the body. The location in the body of the imaged sensor device may be related to an array of internal markers that can, in turn, be related to various anatomical landmarks viewed by an imaging modality. The markers may be imaged using a first imaging modality to determine an internal coordinate system. The first imaging modality may also image the sensor device and/or the anatomical landmark and a location of such determined in the coordinate system. The markers may also be imagable using a second imaging modality that cannot image the sensor device and/or anatomical landmark. The determined coordinate system may be used to localize the sensor device and/or anatomical landmark in the body.

Abstract: The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.

Abstract: Optical to electrical and electrical to optical conversion assemblies provide precise and stable alignment, low loss, unperturbed electrical transmission and high thermal conductivity. Mechanically isolating the ceramic substrate of the conversion assembly relative to the surrounding structures enables good long-term optical alignment. Electrical transmission line connections to and from the optical conversion circuits on the ceramic substrates are made via flexible circuit board designs. The alignment of the components on the substrate relative to the plastic optics is thus preserved. The flexible circuit board includes a cross hatched ground layer, which relieves portions of the metallization below the signal layer and yet is able to maintain the desired transmission line properties. Electrical to optical conversion circuits are provided where the transmission of the electrical signals to the converter circuits is accomplished with minimal loss and with good signal integrity.

Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Abstract: Multi-walled paper sacks for powder products, notably plaster, have a porous paper inner wall surrounded by a paper outer wall and a vapour barrier separate from the paper inner wall. The vapour barrier may be a coating on the inside face of the outer paper wall. Perforations through the vapour barrier are substantially confined to either or both of the broad faces of the sack. During filling of the sacks air is able to vent through the inner wall and then through the perforations in the vapour barrier, allowing filling by high speed machinery. Deterioration of the product as a result of moisture perforation is unexpectedly just as good, and sometimes superior, to that encountered with alternative sacks. Consequently the improvement in filling is not encumbered by a reduction in shelf life of the product.

Abstract: The invention relates to methods of obtaining compositions enriched in hematopoietic stem cells by separating out an enriched fraction of cells expressing the marker CDw109. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention. Methods of use of the cells are also included.

Abstract: A direct digital synthesizer (DDS) for generating a waveform generates a sequence of n-bit phase signals representing phase of the waveform, wherein n is an integer greater than zero. Each n-bit phase signal comprises a phase estimate signal and a phase error signal. The phase estimate signal comprises a most-significant m bits of the n-bit quantity (0 <m<n). The phase-error signal comprises a least-significant n-m bits of the n-bit quantity. The DDS further has a sigma-delta modulator for generating a compensation signal from the phase error signals. The phase estimate signal is added to the compensation signal to produce a compensated phase signal, which may be used to address a look-up table having waveform samples stored in correspondence with look-up table addresses. A digital to analog converter may be coupled to receive waveform samples from the look-up table in order to generate a corresponding analog waveform signal.

Abstract: An apparatus and method for decorrelating pairs of mutually contaminated channels in a multi-channel digital signal including two identical data processing paths and a feedback path. Each pair of mutually contaminated channels consists of a first contaminated channel and a second contaminated channel. Initially, first and second shined signals are generated by shifting the original contaminated signal such that the first shined signal has the first contaminated channel centered at zero frequency and the second shined signal has the second contaminated channel centered at zero frequency. Each of the first and second shifted signals are coupled to one of the two identical signal processing paths. The first path generates an error corruption component corresponding to the first shifted input signal and subtracts this corruption component from the second shifted signal in order to generate a third decorrelated digital signal.

Abstract: A global positioning system (GPS) receiver having a common radio frequency section and a separate digital signal processing channel for each of a plurality of satellite signals which are simultaneously being received and processed by the receiver in order to calculate the position, velocity or other desired parameters of the receiver. The radio frequency section receives and processes both of the standard satellite signals on different frequency L1 and L2 carriers in order to provide the multi-channel digital section signals from which the relative phase of the carriers from each of the plurality of satellites may be determined. Particular mutually coherent local oscillator and digital clock frequencies are selected in order to minimize the complexity of the receiver without creating any undesired side effects.

Abstract: A method of treatment of bacterial infections in humans which comprises administering to a patient one or two unit dosages per day of a compound of formula (I): ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable salting ion or a pharmaceutically acceptable ester-forming radical, andR.sup.2 is hydrogen, a pharmaceutically acceptable salting ion or an in vivo hydrolyzable ester-forming radical.

Abstract: A system is disclosed for sensing a single moving magnetic track, to provide two distinct binary signals (clock and binary data) representative of digital information. Magnetically recorded signals in the Manchester or F/2F code format are selectively processed into electrical representations, using time and amplitude criteria to verify and distinguish between clock (sync) pulses and binary data pulses. An amplitude discriminator is controlled on the basis of the amplitude of immediately prior signals as well as the character of prior binary data pulse signals. A time discriminator is controlled (to segregate clock and data pulse signals) on the basis of the interval of immediately prior signals as well as the character (1 or 0) of prior binary data pulse signals. Consequently, the system is tolerant with regard to signal quality and speed consistency of the relative motion.

Abstract: Compositions containing a mixture of 2-isopropoxynaphth-1-yl penicillin and cephaloridine or cephalothin have been found to show enhanced activity against certain clinically important bacteria.

Abstract: Compositions containing a mixture of 2-isopropoxynaphth-1-yl penicillin and cephaloridine or cephalothin have been found to show enhanced activity against certain clinically important bacteria.