Abstract: In one aspect, the present disclosure provides a formulation comprising a hyaluronidase enzyme and a therapeutically effective amount of an active ingredient. In another aspect, the present disclosure provides a method of administering a high volume of the formulation in a single administration to treat a disease or disorder in a subject.

Abstract: In one aspect, the present disclosure provides a formulation comprising a hyaluronidase enzyme and a therapeutically effective amount of an active ingredient. In another aspect, the present disclosure provides a method of administering a high volume of the formulation in a single administration to treat a disease or disorder in a subject.

Abstract: A card handling device includes a temporary card collection area. The card handling device further includes an elevator platform positioned within the temporary card collection area. The card handling device also includes a wall defining a boundary of the temporary card collection area. The card handling device further includes a card gripper positioned and configured to secure one or more cards in the temporary card collection area between the card gripper and the wall.

Abstract: This invention relates generally to anellovectors, anello VLPs, and compositions and uses thereof.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for estimating wave properties of a body of water. A computer-implemented system obtains measurement data for a duration of time from an inertial measurement unit (IMU) onboard an underwater device, generates model input data based on at least the measurement data obtained at the plurality of time points, and processes the model input data to generate model output data indicating one or more wave properties using a machine-learning model. The system further determines, based on at least the one or more wave properties, whether the device is safe to be deployed.

Abstract: A method and system for performing predictive querying on vector graph document database that includes entities wherein each entity has a Unique IDentifier (UID) tag field, and a schema or array of schema fields, the method including performing probabilistic querying by means of data links that include source, destination, transform, program and data fields, the transform field including a data subfield that refers to the probabilistic, conditional relation between two entities, and a program subfield that defines an infer method and a learn method.

Abstract: Disclosed herein are antibodies, pharmaceutical formulations for treating or preventing Alzheimer's disease, methods of treating or preventing Alzheimer's disease, and kits comprising pharmaceutical formulations for treating or preventing Alzheimer's Disease comprising an anti-A? protofibril antibody and anti-tau antibody.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that validate the synchronization of controllers in an aquaculture environment. An image processor receives images generated by a first image generating device that includes a light filter that is associated with light of a particular light frequency while an aquaculture environment was illuminated with light. The image processor determines whether the intensity value of the light frequency in the image satisfies a threshold value based on the generated image. The image processor determines whether the aquaculture environment was illuminated with light of a particular light frequency when the image was generated based on the whether the intensity value of the particular light frequency in the image exceeds the threshold value. The image processor provides for output an indication of whether the aquaculture was illuminated with light of the particular frequency when the image was generated.

Abstract: A net monitoring system, including: a plurality of net monitoring devices, each net monitoring device including: a housing; a plurality of tensioning arms, each tensioning arm reversibly extendable through the housing and configured to reversibly secure to a net, each tensioning arm including a force sensor configured to generate a tension signal indicative of a tension applied to the corresponding tensioning arm; a tensioning mechanism configured concurrently retract the plurality of tensioning arms into the housing; an impulse generating device, configured to generate an impulse responsive to a command; and a communications device configured to receive the tension signals from the plurality of force sensors, and transmit the tension signals through water; and a controller, configured to: command at least one of the plurality of net monitoring devices to generate the impulse; receive the tension signals responsive to the command to generate the impulse; and determine, based on the received tension signals, a

Abstract: A method for monitoring an aquaculture net, including: transmitting, from a sensor coupled to a net, a signal including information indicative of one or more net state parameters through water; receiving the signal from a sensor coupled to a net, the signal including information indicative of one or more net state parameters; extracting the information from the signal; applying the extracted information as input to a machine learning model trained to determine a net state from the extracted information; determining the presence of a defect in the net.

Abstract: The described technology provides a service risk discovery system for recommending, for a cloud based service sharing the service group hierarchy, a predetermined number of top risk observations based on the ranking of the one or more of the risk observations. The system generates the ranking by joining a plurality of risk objects of one or more of the group of cloud based services based on a service identification field of the plurality of risk objects to generate a service group risk vector, the service group risk vector including a plurality of risk observations for the group of cloud based services.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for estimating wave properties of a body of water. A computer-implemented system obtains measurement data for a duration of time from an inertial measurement unit (IMU) onboard an underwater device, generates model input data based on at least the measurement data obtained at the plurality of time points, and processes the model input data to generate model output data indicating one or more wave properties using a machine-learning model. The system further determines, based on at least the one or more wave properties, whether the device is safe to be deployed.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for real-time monitoring of an aquaculture feeding system using Time Domain Reflectometry (TDR). In one aspect, an aquaculture feeding system comprises: a feed pipe arranged between a dosing system and a fish pen; a feed pipe monitoring subsystem comprising one or more controlled impedance cables arranged along the feed pipe, and a pulse generator configured to generate a series of pulses at a predetermined pulse rate to be transmitted through the controlled impedance cables; and a controller subsystem connected to the feed pipe monitoring subsystem, the controller subsystem configured to: monitor pulse responses along the controlled impedance cables; and detect, from the pulse responses, a condition of the feed pipe.

Abstract: A net monitoring system, including: a plurality of net monitoring devices, each net monitoring device including: a housing; a plurality of tensioning arms, each tensioning arm reversibly extendable through the housing and configured to reversibly secure to a net, each tensioning arm including a force sensor configured to generate a tension signal indicative of a tension applied to the corresponding tensioning arm; a tensioning mechanism configured concurrently retract the plurality of tensioning arms into the housing; an impulse generating device, configured to generate an impulse responsive to a command; and a communications device configured to receive the tension signals from the plurality of force sensors, and transmit the tension signals through water; and a controller, configured to: command at least one of the plurality of net monitoring devices to generate the impulse; receive the tension signals responsive to the command to generate the impulse; and determine, based on the received tension signals, a

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for microplastic removal. In some implementations, a method can include controlling a camera to capture one or more images of plastic in water; providing the one or more images to a machine learning model trained to detect plastic; obtaining output from the machine learning model indicating one or more items of plastic; and controlling one or more acoustic transducers to move the one or more items of plastic.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for automated underwater camera system control for aquaculture systems. An underwater camera system includes (i) a line on which the underwater camera system is mounted, the line detachably affixed to a feeder that provides feed for aquatic livestock, (ii) a sensor manager, (iii) one or more sensors that are managed by the sensor manager, (iv) a line navigation controller, and (v) a first actuator for controlling a distance between the feeder and the underwater camera system. The one or more sensors obtain sensor data and the line navigation controller of the underwater camera system determines a distance to position the underwater camera system beneath the feeder to obtain additional sensor data. The line navigation controller transmits a first message to the first actuator to position the underwater camera system at the determined distance beneath the feeder.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for controlling a remotely operated vehicle (ROV) for performing an underwater task. One apparatus includes a watertight housing; a mounting hardware that attaches the watertight housing to the ROV; one or more sensors in the watertight housing, the one or more sensors configured to generate sensor data that is associated with an underwater task; and one or more processors in the watertight housing, the one or more processors configured to: receive the sensor data from the one or more sensors; generate a navigation plan for the ROV using the sensor data; determine, using the navigation plan, control instructions configured to control the ROV to perform the underwater task; and provide the control instructions to an interface of the ROV configured to communicate with the apparatus.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining drone-based water measurements. One of the methods includes receiving, by a drone management system that controls a drone that is configured to collect water samples, data from a simulator that generates simulation data associated with a body of water; receiving, by the drone management system, an indication that the drone is available to collect one or more water samples from the body of water; determining, by the drone management system and based on the data from the simulator, one or more locations associated with the body of water at which the drone is to collect one or more respective water samples; and; transmitting, by the drone management system, the one or more locations associated with the body of water to the drone.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for adjusting an aquaculture camera mounting system. A current combined field of view of two or more cameras that are mounted on an adjustable camera mounting structure in an environment can be determined based upon a current configuration of the adjustable camera mounting structure. A target field of view for the two or more cameras that are mounted on the adjustable camera mounting structure can be determined. Based at least on the field of view target and the current combined field of view, an adjustment parameter for the adjustable camera mounting structure can be determined. The adjustable camera mounting structure can be adjusted according to the adjustment parameter to provide a field of view in accordance with the field of view target.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that validate the synchronization of controllers in an aquaculture environment. One of the methods includes an image processor that receives images generated by a first image generating device that includes a light filter that is associated with light of a particular light frequency while an aquaculture environment was illuminated with light. Based on the image that was generated by the first image generating device, the image processor determines whether the intensity value of the light frequency in the image satisfies a threshold value. Based on determining whether the intensity value of the light frequency in the image satisfies the threshold value, the image processor determines whether the aquaculture environment was illuminated with light of the particular light frequency when the image was generated.