Abstract: Described herein are methods of treating, preventing, or reducing dendritic spine density loss in a subject, the method comprising administering a compound selected from: metformin, pentosan polysulfate, amlexanox, leflunomide, prasterone, glutathione disulfide, pazopanib, bosutinib, dabrafenib, baricitinib, or a pharmaceutically acceptable salt, prodrug, or derivative thereof; or any combination thereof; or compositions described herein.

Abstract: A planetary inker for an offset printing press which uses only a single ink form roller but is substantially ghost free. A unique arrangement of distributor rollers operably associated with the form roller are present in sufficient number and of relative diameters with respect to each other and to the form roller to assure complete smoothing out of ink supplied to the form roller in conjunction with total elimination of all plate-derived latent images on the surface of the form roller before recontacting the plate on the plate cylinder. Especially efficient transfer of ink from the supply fountain to a drum roller in rolling contact with the form roller ahead of the distributor rollers is obtained in a preferred embodiment by the use of a pair of ink transfer ductors which are alternately intermittently shifted into engagement with the fountain ink ball and then the form roller vibrator. The relative time of engagement of the ductors with the ball and the vibrator may be selectively varied by the operator.