Abstract: Among other things, the present disclosure provides various agents. In some embodiments, provided agents can bind to beta-catenin. In some embodiments, the present disclosure provides technologies for modulating beta-catenin functions. In some embodiments, the present disclosure provides technologies for preventing and/or treating conditions, disorders or diseases associated with beta-catenin. In some embodiments, the present disclosure provides designed amino acids which can provide improved properties and/or activities. In some embodiments, the present disclosure provides agents comprising such amino acids.

Abstract: In some embodiments, the present disclosure provides stapled peptides and compositions thereof. In some embodiments, provided peptides can bind to and modulate functions of estrogen receptor.

Abstract: An optical scope includes a body and an elongated shaft. The shaft distal end holds an optical assembly including an imaging lens with a field of view of at least 90 degrees. An LED is coupled to the body and has an output numerical aperture (NA) providing a critical angle larger than the field of view. A first pair of fiber bundles have proximal ends receiving light from the LED with distal ends presented at the shaft distal face, and an NA providing a critical angle less than the field of view. A second pair of fiber bundles also receive light from the LED with distal ends having at the shaft distal face, and have an NA providing a critical angle at least as large as the field of view. The bundles are positioned around imaging lens such that they create a light having a desired intensity profile and properties.

Abstract: An optical scope includes a body and an elongated shaft. The shaft distal end holds an optical assembly including an imaging lens with a field of view of at least 90 degrees. An LED is coupled to the body and has an output numerical aperture (NA) providing a critical angle larger than the field of view. A first pair of fiber bundles have proximal ends receiving light from the LED with distal ends presented at the shaft distal face, and an NA providing a critical angle less than the field of view. A second pair of fiber bundles also receive light from the LED with distal ends having at the shaft distal face, and have an NA providing a critical angle at least as large as the field of view. The bundles are positioned around imaging lens such that they create a light having a desired intensity profile and properties.

Abstract: This invention provides a system for measuring displacement of an object surface having a displacement sensor that projects a line on the object surface and receives light from the projected line at an imager in a manner defines a plurality of displacement values in a height direction. A vision system processor operates on rows of imager pixels to determine a laser line center in columns of imager pixels in each of a plurality of regions of interest. Each region of interest defines a plurality of rows that correspond with expected locations of the projected line on the object surface. A GUI can be used to establish the regions. In further embodiments, the system generates grayscale images with the imager. These grayscale images can be compared to a generated height image to compensate for contrast-induced false height readings. Imager pixels can be compared to a reference voltage to locate the line.

Abstract: This invention provides a system for measuring displacement of an object surface having a displacement sensor that projects a line on the object surface and receives light from the projected line at an imager in a manner defines a plurality of displacement values in a height direction. A vision system processor operates on rows of imager pixels to determine a laser line center in columns of imager pixels in each of a plurality of regions of interest. Each region of interest defines a plurality of rows that correspond with expected locations of the projected line on the object surface. A GUI can be used to establish the regions. In further embodiments, the system generates grayscale images with the imager. These grayscale images can be compared to a generated height image to compensate for contrast-induced false height readings. Imager pixels can be compared to a reference voltage to locate the line.

Abstract: This invention provides a system for measuring displacement of an object surface having a displacement sensor that projects a line on the object surface and receives light from the projected line at an imager in a manner defines a plurality of displacement values in a height direction. A vision system processor operates on rows of imager pixels to determine a laser line center in columns of imager pixels in each of a plurality of regions of interest. Each region of interest defines a plurality of rows that correspond with expected locations of the projected line on the object surface. A GUI can be used to establish the regions. In further embodiments, the system generates grayscale images with the imager. These grayscale images can be compared to a generated height image to compensate for contrast-induced false height readings. Imager pixels can be compared to a reference voltage to locate the line.

Abstract: This invention provides a system for measuring displacement of an object surface having a displacement sensor that projects a line on the object surface and receives light from the projected line at an imager in a manner defines a plurality of displacement values in a height direction. A vision system processor operates on rows of imager pixels to determine a laser line center in columns of imager pixels in each of a plurality of regions of interest. Each region of interest defines a plurality of rows that correspond with expected locations of the projected line on the object surface. A GUI can be used to establish the regions. In further embodiments, the system generates grayscale images with the imager. These grayscale images can be compared to a generated height image to compensate for contrast-induced false height readings. Imager pixels can be compared to a reference voltage to locate the line.

Abstract: This invention provides a system for measuring displacement of an object surface having a displacement sensor that projects a line on the object surface and receives light from the projected line at an imager in a manner defines a plurality of displacement values in a height direction. A vision system processor operates on rows of imager pixels to determine a laser line center in columns of imager pixels in each of a plurality of regions of interest. Each region of interest defines a plurality of rows that correspond with expected locations of the projected line on the object surface. A GUI can be used to establish the regions. In further embodiments, the system generates grayscale images with the imager. These grayscale images can be compared to a generated height image to compensate for contrast-induced false height readings. Imager pixels can be compared to a reference voltage to locate the line.

Abstract: A system and method for detecting and/or determining the existence of displacement of a substrate with respect to a surrounding object uses a laser line that is free of contact with the object and that is received by an image sensor. A processor reads the line information in a series of image frames, and generates a range image with height information. The height information is provided to a 2D map. Differences between adjacent height measurements, and averages, are computed. Vision system tools are used to accurately locate features in the image and these are aligned with the height information. The height differences are interpreted, with missing height data due, for example, to specularity in the image being approximated. The height differences are compared to predetermined height parameters relative to identified locations, for example, wells, in the object to determine whether a substrate is displaced.

Abstract: A graphical user interface (GUI) display and GUI-based system for displaying and controlling vision system operating parameters of a contour sensor comprises an automated region of interest graphic image applied to a discrete region of a selected image in response to a single click by a user at the discrete region of the selected image, the selected image selected from a window on the GUI display containing a plurality of captured images of the object. At least one automated operating parameter is generated automatically in response to the single click by the user at the discrete region of the selected image to determine whether a contour of interest is in the automated ROI graphic image. The GUI also provides a contour graphic image that outlines the contour of interest to demonstrate whether the contour of interest is in (present or at the correct position within) the automated ROI graphic image.

Abstract: The invention provides, in some aspects, devices for image acquisition that use seals between concentrically disposed portions of an enclosure and an optics assembly in order to protect image acquisition components from the surrounding environment while providing adequate friction for both adjusting and locking focus. Such devices can include an image capture medium that is disposed within an enclosure and an optics assembly that is also disposed within that enclosure. The optics assembly, which includes at least a lens, can have a cylindrical outer diameter along at least a portion of its length that is received within the enclosure along a length that has a corresponding cylindrical inner diameter. A first seal is disposed between, and in contact with, the optics assembly and the enclosure. That seal permits rotation of the optics assembly for purposes of focusing the lens, while preventing contamination from the environment from entering into the enclosure.

Abstract: This invention provides a system for measuring displacement of an object surface having a displacement sensor that projects a line on the object surface and receives light from the projected line at an imager in a manner defines a plurality of displacement values in a height direction. A vision system processor operates on rows of imager pixels to determine a laser line center in columns of imager pixels in each of a plurality of regions of interest. Each region of interest defines a plurality of rows that correspond with expected locations of the projected line on the object surface. A GUI can be used to establish the regions. In further embodiments, the system generates grayscale images with the imager. These grayscale images can be compared to a generated height image to compensate for contrast-induced false height readings. Imager pixels can be compared to a reference voltage to locate the line.

Abstract: This invention provides a Graphical User Interface (GUI) that operates in connection with a machine vision detector or other machine vision system, which provides a highly intuitive and industrial machine-like appearance and layout. The GUI includes a centralized image frame window surrounded by panes having buttons and specific interface components that the user employs in each step of a machine vision system set up and run procedure. One pane allows the user to view and manipulate a recorded filmstrip of image thumbnails taken in a sequence, and provides the filmstrip with specialized highlighting (colors or patterns) that indicate useful information about the underlying images. The programming of logic is performed using a programming window that includes a ladder logic arrangement.

Abstract: A graphical user interface (GUI) display and GUI-based system for displaying and controlling vision system operating parameters of a contour sensor comprises an automated region of interest graphic image applied to a discrete region of a selected image in response to a single click by a user at the discrete region of the selected image, the selected image selected from a window on the GUI display containing a plurality of captured images of the object. At least one automated operating parameter is generated automatically in response to the single click by the user at the discrete region of the selected image to determine whether a contour of interest is in the automated ROI graphic image. The GUI also provides a contour graphic image that outlines the contour of interest to demonstrate whether the contour of interest is in (present or at the correct position within) the automated ROI graphic image.

Abstract: The disclosure relates to a kit for building an exterior wall of a modular building structure. The kit comprises at least two substantially elongated posts and a wall panel for installing on the at least two posts. The wall panel includes a wall panel first attachment and a wall panel second attachment. The wall panel first and second attachments each includes an L-shaped wall panel attachment linking member, an attachment bracket post attachment portion, a wall panel attachment bracket and an attachment bracket spacing section.

Abstract: The present invention generally relates to a self-centering energy dissipative brace apparatus. A bracing system is often needed to stabilize, strengthen or stiffen structures such as buildings which are subjected to severe or extreme conditions. The brace apparatus may be installed in a structure to dissipate input energy and minimize residual deformations related to exceptional loading imposed on the structure by winds, earthquakes, impacts or explosions. The apparatus integrates self-centering properties and energy dissipative capacities which help minimize structural damage.

Abstract: The present invention generally relates to a self-centering energy dissipative brace apparatus. A bracing system is often needed to stabilize, strengthen or stiffen structures such as buildings which are subjected to severe or extreme conditions. The brace apparatus may be installed in a structure to dissipate input energy and minimize residual deformations related to exceptional loading imposed on the structure by winds, earthquakes, impacts or explosions. The apparatus integrates self-centering properties and energy, dissipative capacities which help minimize structural damage.

Abstract: A kit for building a modular building structure. The kit includes a wall panel having a wall panel body, the wall panel body defining a wall panel body first end and a substantially opposed wall panel body second end. The wall panel includes wall panel first and second attachments extending from the wall panel body and located respectively substantially adjacent the wall panel first end. The wall panel first and second attachments are spaced apart relative to each other by a predetermined distance. At least two substantially elongated posts, each including an attachment receiving section for receiving one of the wall panel first and second attachments are also provided. The kit further includes a substantially elongated post positioning member, the post positioning member defining substantially longitudinally opposed post positioning member first and second ends.

Abstract: The present invention generally relates to a self-centering energy dissipative brace apparatus. A bracing system is often needed to stabilize, strengthen or stiffen structures such as buildings which are subjected to severe or extreme conditions. The brace apparatus may be installed in a structure to dissipate input energy and minimize residual deformations related to exceptional loading imposed on the structure by winds, earthquakes, impacts or explosions. The apparatus integrates self-centering properties and energy, dissipative capacities which help minimize structural damage.