Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Disclosed are systems, methods, and articles for determining compatibility of a mobile application and operating system on a mobile device. In some aspects, a method includes receiving one or more data values from a mobile device having a mobile medical software application installed thereon, the data value(s) characterizing a version of the software application, a version of an operating system installed on the mobile device, and one or more attributes of the mobile device; determining whether the mobile medical software application is compatible with the operating system by at least comparing the received data value(s) to one or more test values in a configuration file; and sending a message to the mobile device based on the determining, the message causing the software application to operate in one or more of a normal mode, a safe mode, and a non-operational mode.

Abstract: A system includes a tubing set and a drive assembly. The tubing set includes inlet tubing couplable to a source of fluid, a valve coupled to the inlet tubing, a syringe coupled to the inlet tubing via the valve, and outlet tubing coupled to the valve. The valve is configured to allow fluid to be drawn from the source of fluid via the inlet tubing into a syringe body of the syringe and to be expelled from the syringe body and through the outlet tubing, and to prevent fluid from being drawn from the outlet tubing into the syringe body and to prevent fluid expelled from the syringe body from flowing through the inlet tubing. The drive assembly is configured to reversibly receive the tubing set such that a drive mechanism is engaged with a plunger of the syringe to reciprocally translate the plunger relative to the syringe body.

Abstract: Examples of the present disclosure describe systems and methods for the non-disruptive servicing of components of a user mode process. In examples, a user mode process comprises multiple components, each encapsulating a distinct piece of functionality. A replacement component is loaded and initialized. The replacement component is validated to ensure that the required dependencies of the replacement component are satisfied by the other components of the user mode process. The component to be serviced and the components having dependencies on the component to be serviced are suspended to enable a snapshot of the runtime state of the component to be serviced to be captured. The runtime state is copied to the replacement component and the components having dependencies on the component to be serviced are updated to reference the replacement component. The replacement component is executed and the suspended components are resumed. The component to be serviced is unloaded.

Abstract: A controller of a quantum system causes a geometric phase gate to be performed on two or more qubits by causing two or more qubits of the quantum system to experience a (near field and/or non-radiating) magnetic field gradient; and, responsive to determining that a gate time period has elapsed since the two or more qubits of the quantum system started to experience the magnetic field gradient, causing the two or more qubits to no longer experience the magnetic field gradient. The entanglement of the two or more qubits corresponding to the performance of the gate is enacted, mediated, and/or caused by the magnetic field gradient.

Abstract: A valve repair system for repairing a native valve of a patient during a non-open-heart procedure includes a delivery device and a valve repair device. The valve repair device include a pair of paddles, first gripping member, a second gripping member, and a spacer. First and second gripping member controls or first and second gripping member control portions are coupled to the first and second gripping members to move the gripping members. The spacer element is configured to close a gap in the native valve of the patient when the valve repair device is attached to the native valve.

Abstract: A valve repair device for repairing a native valve of a patient. The valve repair device includes a compressible spacer element, a pair of paddles, and a pair of gripping members. The pair of paddles are coupled to the spacer element. The pair of gripping members are disposed between the pair of paddles. The paddles and the gripping members are configured to attach to leaflets of a heart valve.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: Quorum-based access control management may be implemented. Quorum controls may be created for determining whether to perform or deny access control operations to perform privileged tasks. When an access control operation is received, approval of the operation may be requested from members for the quorum control. If a policy for the quorum control is satisfied by approval responses, then approval to perform the access control operation may be provided.

Abstract: An electrical header for use in an electrical connector assembly includes a body for mounting to an object and having an opening formed therethrough for receiving an electrical terminal. The body further defines a plug on a first side thereof for engaging with a mating electrical connector of the assembly. The plug includes a pair of first opposing sidewalls extending from the body at a first height and defining a locking feature for engaging with a corresponding locking feature of the mating connector, and a pair of second opposing sidewalls extending from the body at a second height, less than the first height. The first and second pairs of opposing sidewalls are adapted to mate with a first mating connector oriented in a first direction, and mate with a second mating connector oriented in a second direction distinct from the first direction.

Abstract: Systems and methods for determining and reporting actual utilization of a core of a central processing unit (CPU) of a host. Prior to implementation of aspects of the present disclosure, running a poll querying endpoints of a process for work appears to the host's operating system as busy work (e.g., taking full use of the core for the poll duration). However, only a percentage of the duration of the poll is used to process a task of the process, where the remaining duration of the poll is spent querying the endpoints (idle time) and the core is not performing a task. Accordingly, a core utilization reporting system and method automatically detects the processing time of the tasks of a process, determines actual CPU utilization of the core based on a percentage of the time the core is busy polling (doing effectively no work) versus doing actual work (processing a task).

Abstract: A trapped-ion quantum logic gate and a method of operating the trapped-ion quantum logic gate are provided. The trapped-ion quantum logic gate includes at least one ion having two internal states and forming a qubit having a qubit transition frequency ?0, a magnetic field gradient, and two microwave fields. Each of the two microwave fields has a respective frequency that is detuned from the qubit transition frequency ?0 by frequency difference ?. The at least one ion has a Rabi frequency ?? due to the two microwave fields and a Rabi frequency ?g due to the magnetic field gradient. The method includes applying the magnetic field gradient and the two microwave fields to the at least one ion such that a quantity ?g/? is in a range between zero and 5×10?2.

Abstract: An automated slide drilling system (ASDS) may be used with a drilling rig system to control slide drilling. The ASDS may autonomously control slide drilling without user input during the slide drilling. The ASDS may further support a transition from rotary drilling to slide drilling to rotary drilling without user input during the transitions. The ASDS may also support user input and user notifications for various steps to enable manual or semi-manual control of slide drilling by a driller or an operator.

Abstract: A method and apparatus for assembling a hanging scaffold system within the aft pressure bulkhead area of an aircraft to provide access to the pressure dome without contacting the pressure dome. The hanging scaffold system comprises a group of horizontal supports to support at least one floorboard. A group of vertical supports is connected to and extends perpendicularly from the group of horizontal supports. A clamping device is attached to each vertical support of the group of vertical supports and further engages an attachment point on an internal structure of an aircraft.

Abstract: An automated slide drilling system (ASDS) may be used with a drilling rig system to control slide drilling. The ASDS may autonomously control slide drilling without user input during the slide drilling. The ASDS may further support a transition from rotary drilling to slide drilling to rotary drilling without user input during the transitions. The ASDS may also support user input and user notifications for various steps to enable manual or semi-manual control of slide drilling by a driller or an operator.

Abstract: Silicon carbide (SiC) crystalline materials and related methods are disclosed that provide SiC crystalline materials with reduced optical absorption. In certain aspects, SiC crystalline materials with reduced absorption coefficients for wavelengths of light within the visible spectrum are disclosed. Various peaks in absorption over a wavelength spectrum may be reduced in SiC crystalline materials to improve overall absorption coefficient uniformity across the visible spectrum. By providing such improvements in absorption coefficients for SiC crystalline materials, reduced reflection and transmission losses of light in corresponding devices may be realized. Related methods are disclosed that include various combinations of crystalline growth, with and without various post-growth thermal conditioning steps.

Abstract: Silicon carbide (SiC) materials including SiC wafers and SiC boules and related methods are disclosed that provide large dimension SiC wafers with reduced crystallographic stress. Growth conditions for SiC materials include maintaining a generally convex growth surface of SiC crystals, adjusting differences in front-side to back-side thermal profiles of growing SiC crystals, supplying sufficient source flux to allow commercially viable growth rates for SiC crystals, and reducing the inclusion of contaminants or non-SiC particles in SiC source materials and corresponding SiC crystals. By forming larger dimension SiC crystals that exhibit lower crystallographic stress, overall dislocation densities that are associated with missing or additional planes of atoms may be reduced, thereby improving crystal quality and usable SiC crystal growth heights.

Abstract: Wafer images and related alignment methods for crystalline wafers are disclosed. Certain aspects relate to accessing and aligning images of a same or similar crystalline wafer captured from different imaging sources. Alignment may include determining spatial differences between shared crystalline features in various wafer images of the same or similar crystalline wafer and transforming at least one of the images according to the determined spatial differences. With sufficient alignment, information may be associated and/or transferred between the various images, thereby providing the capability of forming a combined wafer image and sub-images thereof with high resolution and spatial coordination between different image sources. Certain aspects relate to development of nondestructive, high fidelity defect characterization and/or dislocation counting methods in crystalline materials based on modern deep convolutional neural networks (DCNN).

Abstract: A unified digital image selection system is described for selection and editing of both vector and raster graphics together. In one example, a first user input is received that selects a region of a digital image. In response to the first user input, a vector selection representation is generated of at least a portion of a vector graphic included in the selected region. A raster selection representation is also generated of at least a portion of a raster graphic included in the selected region in response to the first user input. A second user input is also received specifying a digital image editing operation. In response to the second user input, both the vector selection representation and the raster selection representation using the digital editing operation. The digital image is then displayed as having the edited vector selection representation and the edited raster selection representation.

Abstract: Wafer images and related alignment methods for crystalline wafers are disclosed. Certain aspects relate to accessing and aligning images of a same or similar crystalline wafer captured from different imaging sources. Alignment may include determining spatial differences between shared crystalline features in various wafer images of the same or similar crystalline wafer and transforming at least one of the images according to the determined spatial differences. With sufficient alignment, information may be associated and/or transferred between the various images, thereby providing the capability of forming a combined wafer image and sub-images thereof with high resolution and spatial coordination between different image sources. Certain aspects relate to development of nondestructive, high fidelity defect characterization and/or dislocation counting methods in crystalline materials based on modern deep convolutional neural networks (DCNN).