Patents by Inventor Robert A. Warwick

Robert A. Warwick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods comprising long-chain, straight-chain 2-amino-3-hydroxyalkanes
    Patent number: 7109244
    Abstract: Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumor long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group. The present invention is directed to compositions and methods comprising an isolated and purified long-chain, straight-chain 2-amino-3-hydroxyalkane, or prodrug thereof, and a pharmaceutically acceptable carrier, wherein the carbon chain in the long-chain, straight-chain 2-amino-3-hydroxyalkane is C16–C24.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: September 19, 2006
    Inventors: Kenneth L. Rinehart, Robert A. Warwick, Jesus Avila, Nancy L. Fregeau Gallagher, Dolores Garcia Gravalos, Glynn T. Faircloth
  • Spisulosine compounds
    Patent number: 6800661
    Abstract: Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: October 5, 2004
    Assignee: Board of Trustees of the University of Illinois
    Inventors: Kenneth L. Rinehart, Robert A. Warwick, Jesus Avila, Nancy L. Fregeau Gallagher, Dolores Garcia Gravalos, Glynn T. Faircloth
  • Spisulosine compounds
    Publication number: 20040147615
    Abstract: Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.
    Type: Application
    Filed: October 23, 2003
    Publication date: July 29, 2004
    Inventors: Kenneth L. Rinehart, Robert A. Warwick, Jesus Avila, Nancy L. Fregeau Gallagher, Dolores Garcia Gravalos, Glynn T. Faircloth
  • Spisulosine compounds
    Patent number: 6107520
    Abstract: The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cytotoxicity against L1210 murine lymphocytic leukemia cells. In addition, sphingosine (also referred to as 4-sphingenine or octadeca-4-shpingenine, 4) and two related compounds, nonadeca-4-sphingenine (a one carbon longer homolog, 5) and sphinga-4,10-diene (a dehydrosphingosine deravitive, 6) were also obtained, These compounds also contribute to the cytotoxicity of the Spisula polynyma extracts, but did not cause the morphology changes observed with compounds 1-3.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: August 22, 2000
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kenneth L. Rinehart, Nancy L. Fregeau, Robert A. Warwick
  • Boat mooring device
    Patent number: 4067283
    Abstract: A boat mooring device for being detachably affixed to the side of a pile extending upright in the water and which device has a vertically moveable element attachable to a boat for retaining the boat to the pile, but riding up and down with the boat during changes of tide or waves.
    Type: Grant
    Filed: May 18, 1977
    Date of Patent: January 10, 1978
    Inventor: Robert A. Warwick
  • Spisulosine compounds
    Patent number: RE38793
    Abstract: The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cytotoxicity against L1210 murine lymphocytic leukemia cells. In addition, sphingosine (also referred to as 4-sphingenine or octadeca-4-shpingenine, 4) and two related compounds, nonadeca-4-sphingenine (a one carbon longer homolog, 5) and sphinga-4,10-diene (a dehydrosphingosine deravitive, 6) were also obtained, These compounds also contribute to the cytotoxicity of the Spisula polynyma extracts, but did not cause the morphology changes observed with compounds 1-3.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: September 6, 2005
    Inventors: Kenneth L. Rinehart, Nancy L. Gallagher, Robert A. Warwick