Abstract: Methods and systems are described for providing deep brain stimulation (DBS) of the subcallosal cingulate region (SCC) to provide symptom relief in patients with treatment-resistant depression (TRD). The DBS devices may enable chronic electrophysiology recording to deliver SCC DBS therapy. One or more machine-learning models may identify SCC LFP changes that indicate the patient's current clinical state. The clinical state is distinct from acute transient stimulation effects, is sensitive to DBS stimulation adjustments, and accurately captures individual differences in recovery trajectory.

Abstract: The present disclosure relates generally to the preparation and use of certain botanical extracts and therapeutic compositions for the treatment of viral infections, cancer, pain, itch, and inflammation. The present disclosure generally relates to antiviral compositions, and more specifically to the preparation of botanical extracts and their use in the treatment of viral infections, cancer, pain associated conditions.

Abstract: The present disclosure relates generally to the preparation and use of certain botanical extracts and therapeutic compositions for the treatment of viral infections, cancer, pain, itch, and inflammation. The present disclosure generally relates to antiviral compositions, and more specifically to the preparation of botanical extracts and their use in the treatment of viral infections, cancer, pain associated conditions.

Abstract: The present disclosure relates generally methods of preparation and use of certain botanical extracts for the treatment of viral infections.

Abstract: The present disclosure relates generally to the preparation and use of certain botanical extracts and therapeutic compositions for the treatment of viral infections, cancer, pain, itch, and inflammation. The present disclosure generally relates to antiviral compositions, and more specifically to the preparation of botanical extracts and their use in the treatment of viral infections, cancer, pain associated conditions.

Abstract: A cover assembly for an internal combustion engine application and method of construction therefore provides one construction for a valve cover assembly, and another construction for an end cover assembly for a crankcase. The cover assemblies include at least one rigid metal carrier having a plurality of bolt openings and a plurality of load limiters located about said openings. A material is overmolded on the carrier and about the load limiters, with the material forming an exposed sealing surface for direct engagement with a seal gasket.

Abstract: In one general aspect, a sign connector is provided. The sign connector including: a first bracket connected to a first sign, the first bracket including a receiving means; and a second bracket including a first and second member, an end of the first member attached to an end of the second member to form an angle between the first member and the second member, and the first member is detachably connected to a second sign and the second member is adapted to be received within the receiving means of the first bracket.

Abstract: A cover assembly for an internal combustion engine application and method of construction therefore provides one construction for a valve cover assembly, and another construction for an end cover assembly for a crankcase. The cover assemblies include at least one rigid metal carrier having a plurality of bolt openings and a plurality of load limiters located about said openings. A material is overmolded on the carrier and about the load limiters, with the material forming an exposed sealing surface for direct engagement with a seal gasket.

Abstract: A cover assembly for an internal combustion engine application and method of construction therefore provides one construction for a valve cover assembly, and another construction for an end cover assembly for a crankcase. The cover assemblies include at least one rigid metal carrier having a plurality of bolt openings and a plurality of load limiters located about said openings. A material is overmolded on the carrier and about the load limiters, with the material forming an exposed sealing surface for direct engagement with a seal gasket.

Abstract: A cover assembly for an internal combustion engine application and method of construction therefore provides one construction for a valve cover assembly, and another construction for an end cover assembly for a crankcase. The cover assemblies include at least one rigid metal carrier having a plurality of bolt openings and a plurality of load limiters located about said openings. A material is overmolded on the carrier and about the load limiters, with the material forming an exposed sealing surface for direct engagement with a seal gasket.

Abstract: An apparatus for an electrical wiring hub is provided. The electrical wiring hub includes: a hub housing, configured to receive a plurality of wires; a plurality of conductor rings, configured to conduct electrical current from one of the plurality of wires to another of the plurality of wires; a conductor mount, configured to receive at least one conductor ring; a conductor retainer, configured engage the hub housing and the conductor mount and configured to maintain a position of the plurality of conductor rings.

Abstract: An apparatus for an electrical wiring hub is provided. The electrical wiring hub includes: a hub housing, configured to receive a plurality of wires; a plurality of conductor rings, configured to conduct electrical current from one of the plurality of wires to another of the plurality of wires; a conductor mount, configured to receive at least one conductor ring; a conductor retainer, configured engage the hub housing and the conductor mount and configured to maintain a position of the plurality of conductor rings.

Abstract: A method to guide a drilling path of a second well in proximity to a first well including: applying a time-varying electrical current to a conductive casing or liner of the first well; from the drilling path of the second well, sensing an electromagnetic field generated by the current in the first well, and guiding the drilling path trajectory of the second well using the sensed electromagnetic field.

Abstract: The subject invention discloses a sealing assembly that includes a first component and a second component moveable into and out of mating engagement to form a seal therebetween. The first component has a first sealing surface defining a groove and a sealing bead extends upwardly a predetermined height therefrom. The sealing bead is molded within the groove. The second component has a second sealing surface defining a recess for contacting the sealing bead. When the first and the second components are brought into mating engagement, the sealing bead compresses at most 40% of the predetermined height when the second sealing surface contacts the sealing bead.

Abstract: A liquefying apparatus for melting solid materials has a hopper with a coiled heating element disposed therein which supports and melts the solid materials into a liquid form. The liquid is stored below the heating element in a bottom section of the hopper, and is continually adjusted to a predetermined level, in order to insure that 1) the liquid in the lower section has a substantially constant temperature distribution and 2) a skin or film is not formed on the heating element which would reduce the liquefying rate.

Abstract: A buoyant cable, particular for magnetic minesweeping applications, comprising a bundle of electrically conductive tubes (1) with an overall electrically-insulating sheath (4), the tubes providing buoyancy, strength and electrical conductivity for the cable. The sheath may have an internal reinforcing braid.

Abstract: Wipers for sliding electrical contact have a form with gradual and progressive reduction in width and therfore decreasing stiffness and mass as they proceed towards the tip. This form results in higher resonant vibrational frequencies, enabling a wiper to follow the contact surface in high speed motion with less contact force. The lower contact force in turn produces less wiper distortion and consequently less hysteresis and wear.