Abstract: A method of antagonizing the effects of an oncogene by constructing an artificial gene which antagonizes the function of the oncogene is described herein. In one embodiment, the artificial gene comprises a transcriptional promoter segment, an inverted oncogene segment, and a polyadenylation segment.

Abstract: Experiments designed to define the differences between an oncogene isolated from human bladder cancer cells and its corresponding proto-oncogene are described herein. By a series of in vitro recombinations, the difference was initially isolated to a 350 kb segment of DNA; sequencing defined the difference as a change in the Gly.sup.12 codon causing the p21 protein of the oncogene to contain valine at a location where the p21 protein of the proto-oncogene contained glycine. Assays for detecting carcinogenesis based on such differences are also described. In one type of assay, a restriction enzyme specific for either the altered or non-altered DNA segment of the genes are employed to detect carcinogenesis. In another type of assay, seralogical reagents, such as antibody specific for either p21 protein expressed from the proto-oncogene or oncogene, or a common site therein, are described.

Abstract: An advertising display device for displaying a newspaper or an analogous article on a wire rack includes a folded transparent element which has a generally rectangular front panel and a rear panel juxtaposed therewith so as to bound an interior space in which an article to be displayed is received. A plurality of mounting holes is provided at different locations on the rear panel for adjustably mounting the folded element at any of a plurality of positions relative to the wire rack. The article contained intermediate the panels is thus visible to a viewer at any selected one of these positions.

Abstract: A display device and arrangement for displaying a newspaper or an analogous article includes a folded transparent element which has a generally rectangular front panel and a juxtaposed rear panel. The folded element has an open upper end in the region of its free edges for receiving an article to be displayed intermediate the panels, and a closed lower end in the region of its fold for holding the article in position therein. The folded element is mounted on a support, such as a wire rack.