Patents by Inventor Robert A. Yuan

Robert A. Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12313588
    Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.
    Type: Grant
    Filed: May 12, 2023
    Date of Patent: May 27, 2025
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
  • Patent number: 11846281
    Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: December 19, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventor: Robert A Yuan
  • Publication number: 20230280308
    Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.
    Type: Application
    Filed: May 12, 2023
    Publication date: September 7, 2023
    Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
  • Patent number: 11686706
    Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: June 27, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
  • Publication number: 20220299472
    Abstract: A nanopore based sequencing chip package is disclosed. The nanopore based sequencing chip package includes a reservoir defined by a plurality of surfaces. The chip package includes a nanopore cell array comprising a plurality of nanopore sensor cells enclosed by the reservoir. Each nanopore sensor cell has a working electrode. At least one surface of the reservoir is configured to be in contact with a conducting fluid when the conducting fluid is flowing through the reservoir. The chip package further includes a counter electrode disposed on the at least one surface of the reservoir.
    Type: Application
    Filed: June 2, 2022
    Publication date: September 22, 2022
    Inventors: J. William Maney, JR., David Bruce Robinson, Markus Wallgren, Robert A. Yuan
  • Publication number: 20220291192
    Abstract: A consumable device used in a nanopore based sequencing system can include a nanopore chip, a flow cell with one or more flow channels, and a flow cell cover. A fluidic interface can be used to deliver fluid to the flow cell. The fluid interface can include a flow cell boss and the flow cell cover can include a receptacle for receiving the flow cell boss. A dispense tip can be used to introduce fluid into the flow cell through the flow cell boss.
    Type: Application
    Filed: September 22, 2020
    Publication date: September 15, 2022
    Inventors: Matthew DiPietro, Damion Engelbart, Andrew Liu, William Nielsen, Janusz B. Wojtowicz, Robert A. Yuan
  • Publication number: 20210115915
    Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.
    Type: Application
    Filed: November 12, 2020
    Publication date: April 22, 2021
    Inventor: Robert A. Yuan
  • Patent number: 10837440
    Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: November 17, 2020
    Assignee: Roche Sequencing Solutions, Inc.
    Inventor: Robert A. Yuan
  • Publication number: 20200348261
    Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.
    Type: Application
    Filed: July 15, 2020
    Publication date: November 5, 2020
    Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
  • Patent number: 10718737
    Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 21, 2020
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Robert A. Yuan, Janusz B. Wojtowicz, Edward Liu, Kenneth M. Stothers, Markus Wallgren
  • Patent number: 10371664
    Abstract: A nanopore cell includes a titanium nitride (TiN) counter electrode configured to be at a first electric potential. The nanopore cell also include a working electrode configured to be at a second electric potential and an insulating wall. The insulating wall and the working electrode form at least a portion of a well configured to contain an electrolyte at a voltage that is at least a portion of an electric potential difference between the first electric potential of the titanium nitride counter electrode and the second electric potential of the working electrode.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: August 6, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Markus Wallgren, Janusz B. Wójtowicz, Robert A. Yuan, John Foster, Jason Komadina
  • Patent number: 10234446
    Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: March 19, 2019
    Assignee: Genia Technologies, Inc.
    Inventor: Robert A. Yuan
  • Publication number: 20180306181
    Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.
    Type: Application
    Filed: April 17, 2018
    Publication date: October 25, 2018
    Inventor: Robert A. Yuan
  • Patent number: 10008037
    Abstract: An augmented reality environment allows interaction between virtual and real objects. By monitoring user actions with the augmented reality environment various functions are provided to users. Users may buy or sell items with a gesture, check inventory of objects in the augmented reality environment, view advertisements, and so forth.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: June 26, 2018
    Assignee: Amazon Technologies, Inc.
    Inventors: William Spencer Worley, III, Edward Dietz Crump, Robert A. Yuan, Christopher Coley, Colter E. Cederlof
  • Patent number: 9996972
    Abstract: An augmented reality environment allows interaction between virtual and real objects. By monitoring user actions with the augmented reality environment various functions are provided to users. Users may buy or sell items with a gesture, check inventory of objects in the augmented reality environment, view advertisements, and so forth.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: June 12, 2018
    Assignee: Amazon Technologies, Inc.
    Inventors: William Spencer Worley, III, Edward Dietz Crump, Colter E. Cederlof, Christopher Coley, Robert A. Yuan
  • Patent number: 9970437
    Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: May 15, 2018
    Assignee: Genia Technologies, Inc.
    Inventor: Robert A. Yuan
  • Patent number: 9921641
    Abstract: An augmented reality environment allows interaction between virtual and real objects. By monitoring user actions with the augmented reality environment various functions are provided to users. Users may buy or sell items with a gesture, check inventory of objects in the augmented reality environment, view advertisements, and so forth.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: March 20, 2018
    Assignee: Amazon Technologies, Inc.
    Inventors: William Spencer Worley, III, Christopher Coley, Robert A. Yuan, Edward Dietz Crump, Colter E. Cederlof
  • Patent number: 9885352
    Abstract: A delivery system for a sensor chip includes a plurality of selectable ports arranged on a first assembly. Each of the selectable ports is in communication with a separate channel. The delivery system includes a second assembly movable in relation to the first assembly. The second assembly has a channel that is mechanically connectable to different ones of the plurality of selectable ports on the first assembly by motion of the second assembly relative to the first assembly. The delivery system includes a mechanical interface configured to engage a separate actuator so that relative motion of the first assembly and the second assembly is affected by the actuator.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: February 6, 2018
    Assignee: Genia Technologies, Inc.
    Inventor: Robert A. Yuan
  • Publication number: 20180017543
    Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.
    Type: Application
    Filed: September 8, 2017
    Publication date: January 18, 2018
    Inventor: Robert A. Yuan
  • Patent number: 9791432
    Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: October 17, 2017
    Assignee: Genia Technologies, Inc.
    Inventor: Robert A. Yuan