Patents by Inventor Robert A. Yuan
Robert A. Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12313588Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: GrantFiled: May 12, 2023Date of Patent: May 27, 2025Assignee: Roche Sequencing Solutions, Inc.Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
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Patent number: 11846281Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: GrantFiled: November 12, 2020Date of Patent: December 19, 2023Assignee: Roche Sequencing Solutions, Inc.Inventor: Robert A Yuan
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Publication number: 20230280308Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: ApplicationFiled: May 12, 2023Publication date: September 7, 2023Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
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Patent number: 11686706Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: GrantFiled: July 15, 2020Date of Patent: June 27, 2023Assignee: Roche Sequencing Solutions, Inc.Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
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Publication number: 20220299472Abstract: A nanopore based sequencing chip package is disclosed. The nanopore based sequencing chip package includes a reservoir defined by a plurality of surfaces. The chip package includes a nanopore cell array comprising a plurality of nanopore sensor cells enclosed by the reservoir. Each nanopore sensor cell has a working electrode. At least one surface of the reservoir is configured to be in contact with a conducting fluid when the conducting fluid is flowing through the reservoir. The chip package further includes a counter electrode disposed on the at least one surface of the reservoir.Type: ApplicationFiled: June 2, 2022Publication date: September 22, 2022Inventors: J. William Maney, JR., David Bruce Robinson, Markus Wallgren, Robert A. Yuan
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Publication number: 20220291192Abstract: A consumable device used in a nanopore based sequencing system can include a nanopore chip, a flow cell with one or more flow channels, and a flow cell cover. A fluidic interface can be used to deliver fluid to the flow cell. The fluid interface can include a flow cell boss and the flow cell cover can include a receptacle for receiving the flow cell boss. A dispense tip can be used to introduce fluid into the flow cell through the flow cell boss.Type: ApplicationFiled: September 22, 2020Publication date: September 15, 2022Inventors: Matthew DiPietro, Damion Engelbart, Andrew Liu, William Nielsen, Janusz B. Wojtowicz, Robert A. Yuan
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Publication number: 20210115915Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: ApplicationFiled: November 12, 2020Publication date: April 22, 2021Inventor: Robert A. Yuan
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Patent number: 10837440Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: GrantFiled: April 17, 2018Date of Patent: November 17, 2020Assignee: Roche Sequencing Solutions, Inc.Inventor: Robert A. Yuan
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Publication number: 20200348261Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: ApplicationFiled: July 15, 2020Publication date: November 5, 2020Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
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Patent number: 10718737Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: GrantFiled: January 19, 2017Date of Patent: July 21, 2020Assignee: Roche Sequencing Solutions, Inc.Inventors: Robert A. Yuan, Janusz B. Wojtowicz, Edward Liu, Kenneth M. Stothers, Markus Wallgren
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Patent number: 10371664Abstract: A nanopore cell includes a titanium nitride (TiN) counter electrode configured to be at a first electric potential. The nanopore cell also include a working electrode configured to be at a second electric potential and an insulating wall. The insulating wall and the working electrode form at least a portion of a well configured to contain an electrolyte at a voltage that is at least a portion of an electric potential difference between the first electric potential of the titanium nitride counter electrode and the second electric potential of the working electrode.Type: GrantFiled: January 19, 2017Date of Patent: August 6, 2019Assignee: Roche Molecular Systems, Inc.Inventors: Markus Wallgren, Janusz B. Wójtowicz, Robert A. Yuan, John Foster, Jason Komadina
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Patent number: 10234446Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.Type: GrantFiled: September 8, 2017Date of Patent: March 19, 2019Assignee: Genia Technologies, Inc.Inventor: Robert A. Yuan
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Publication number: 20180306181Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: ApplicationFiled: April 17, 2018Publication date: October 25, 2018Inventor: Robert A. Yuan
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Patent number: 10008037Abstract: An augmented reality environment allows interaction between virtual and real objects. By monitoring user actions with the augmented reality environment various functions are provided to users. Users may buy or sell items with a gesture, check inventory of objects in the augmented reality environment, view advertisements, and so forth.Type: GrantFiled: June 10, 2011Date of Patent: June 26, 2018Assignee: Amazon Technologies, Inc.Inventors: William Spencer Worley, III, Edward Dietz Crump, Robert A. Yuan, Christopher Coley, Colter E. Cederlof
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Patent number: 9996972Abstract: An augmented reality environment allows interaction between virtual and real objects. By monitoring user actions with the augmented reality environment various functions are provided to users. Users may buy or sell items with a gesture, check inventory of objects in the augmented reality environment, view advertisements, and so forth.Type: GrantFiled: June 10, 2011Date of Patent: June 12, 2018Assignee: Amazon Technologies, Inc.Inventors: William Spencer Worley, III, Edward Dietz Crump, Colter E. Cederlof, Christopher Coley, Robert A. Yuan
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Patent number: 9970437Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: GrantFiled: September 28, 2015Date of Patent: May 15, 2018Assignee: Genia Technologies, Inc.Inventor: Robert A. Yuan
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Patent number: 9921641Abstract: An augmented reality environment allows interaction between virtual and real objects. By monitoring user actions with the augmented reality environment various functions are provided to users. Users may buy or sell items with a gesture, check inventory of objects in the augmented reality environment, view advertisements, and so forth.Type: GrantFiled: June 10, 2011Date of Patent: March 20, 2018Assignee: Amazon Technologies, Inc.Inventors: William Spencer Worley, III, Christopher Coley, Robert A. Yuan, Edward Dietz Crump, Colter E. Cederlof
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Patent number: 9885352Abstract: A delivery system for a sensor chip includes a plurality of selectable ports arranged on a first assembly. Each of the selectable ports is in communication with a separate channel. The delivery system includes a second assembly movable in relation to the first assembly. The second assembly has a channel that is mechanically connectable to different ones of the plurality of selectable ports on the first assembly by motion of the second assembly relative to the first assembly. The delivery system includes a mechanical interface configured to engage a separate actuator so that relative motion of the first assembly and the second assembly is affected by the actuator.Type: GrantFiled: September 28, 2015Date of Patent: February 6, 2018Assignee: Genia Technologies, Inc.Inventor: Robert A. Yuan
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Publication number: 20180017543Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.Type: ApplicationFiled: September 8, 2017Publication date: January 18, 2018Inventor: Robert A. Yuan
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Patent number: 9791432Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.Type: GrantFiled: March 20, 2015Date of Patent: October 17, 2017Assignee: Genia Technologies, Inc.Inventor: Robert A. Yuan